Integrative review of resin-based dental pit and fissure sealants: Composition analysis and a novel categorization proposal

Paweł J. Piszko; Paulina Drapiewska; Julia Kurczyk; Natalia Stelmaszczyk; Michał J. Kulus; Aleksandra Piszko; Maciej Dobrzyński

doi:10.2478/msp-2026-0006

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Integrative review of resin-based dental pit and fissure sealants: Composition analysis and a novel categorization proposal

Materials Science-Poland

Volume 44 (2026): Issue 1 (March 2026)

By: Paweł J. Piszko, Paulina Drapiewska, Julia Kurczyk, Natalia Stelmaszczyk, Michał J. Kulus, Aleksandra Piszko and Maciej Dobrzyński

Open Access

|Apr 2026

Figures & Tables

Graphical illustration of the operation principle of dental sealants.

Bubble heatmap depicting the classification of the rarity of ingredients identified in the dental sealant formulations and the size of each group.

Table 1

Composition of identified dental pit and fissure sealants with respective quantity of ingredients.

No.	Product Name	Manufacturer	Chemical compound	Quantity	Reference
1.1	Embrace Wet Bond	Pulpdent Corporation, Watertown, Massachusetts, USA	Uncured acrylate ester monomers	55–60%	[16]
			FS	5%
			NaF	<2%
1.2	Embrace Wet Bond	Pulpdent Corporation, Watertown, Massachusetts, USA	Aliphatic urethane dimethacrylate	—	[17]
			Bis-methacryloyl phosphate	—
			HEMA	—
			TMPTMA	—
			H₂O
			NaF	—
			SiO₂	—
2	Fotoseal	Remed Prodimpex SRL, Bucharest, Romania	Dimethacrylate monomer mixture	60%	[17,18]
			Colloidal silica	40%
			TiO₂
			Eutectic fluoride
3.1	3M Clinpro Sealant	3M, St. Paul, Minnesota, USA	Bis-GMA	40–50%	[19]
			TEGDMA	40–50%
			Silane-treated silica	5–10%
			TBATFB	<5%
			DPIHFP	<1%
			TiO₂	<0.5%
			SbPh₃	<0.5%
			EDB	<0.3%
			HQ	<0.05%
3.2	3M Clinpro Sealant	3M, St. Paul, Minnesota, USA	TEGDMA	—	[20]
			Bis-GMA	—
			TBATFB	—
			Dichloride methylsilane	—
			Silica	6%
			Dye	—
4.1	UltraSeal XT Plus	Ultradent Products inc, South Jordan, Utah, USA	TEGDMA	>10–≤25%	[21]
			UDMA	1–10%
			HEMA	≥0.1–<1%
			Trade Secret	≥0.1–<1%
4.2	UltraSeal XT Plus	Ultradent Products inc, South Jordan, Utah, USA	UDMA	<10%	[22]
			Bis-GMA	<20%
			DMAEMA	<1%
			SMFP	<1%
			TiO₂	<1%
			Fillers	58%
5	SEAL-RITE PIT AND FISSURE SEALANT	Pulpdent Corporation, Watertown, Massachusetts, USA	Uncured acrylate ester monomers	55–65%	[23]
			FS	5%
			NaF	<2%
6	Helioseal	Ivoclar Vivadent, Schaan, Lichtenstein	Bis-GMA	58.30%	[24,25]
			TEGDMA	38.1%
			TiO₂	2.1%
			Catalysts	1.6%
			Stabilizers
7.1	Helioseal F	Ivoclar Vivadent, Schaan, Lichtenstein	Bis-GMA	11.8%	[24]
			TEGDMA	23.40%
			UDMA	23.40%
			Fluorosilicate glass	40.50%
			SiO₂
			TiO₂	0.6%
			Stabilizers	0.3%
			Catalysts
7.2	Helioseal F	Ivoclar Vivadent, Schaan, Lichtenstein	Bis-GMA	—	[26]
			UDMA	—
			TEGDMA	—
			Fluorosilicate glass	20%
			SiO₂	21.5%
8	Helioseal Clear	Ivoclar Vivadent, Schaan, Lichtenstein	Big-GMA	60.0%	[24,27]
			TEGDMA	39.3%
			Stabilizers	0.7%
			Catalysts
9.1	Conseal F	SDI, Victoria, Australia	Acrylic monomer	93%	[28,29]
			Silica	7%
			TiO₂	0.01%
			NaF	0.01%
9.2	Conseal F	SDI, Victoria, Australia	UDMA	50–70%	[30]
10.1	GUARDIAN SEAL	Kerr corporation, Orange, California, USA	Uncured methacrylate ester monomers	60–65%	[31]
			Mineral fillers	—
			Photoinitiators	—
			Stabilizing additives	—
10.2	GUARDIAN SEAL	Kerr corporation, Orange, California, USA	Fluoride releasing monomer: BF3	—	[32]
			Bis-GMA	—
			CQ	—
			Silica	—
11.1	DELTON Plus Light Cure Opaque Sealant	DENTSPLY Professional, York, USA	Resin blend	55–65%	[33]
			Silanated milled glass	30–40%
			NaF	1–2%
			TiO₂	<1%
11.2	DELTON Plus Light Cure Opaque Sealant	DENTSPLY Professional, York, USA	Aromatic and aliphatic dimethacrylate	91.20%	[22]
			TiO₂	1.50%
			SiO₂	5.40%
			EDB	1.00%
			Light activators	>1%
12	FluroShield VLC	Dentsply Sirona, Milford, USA	Urethane modified Bis-GMA dimethacrylate	<40%	[22,34]
			Barium boron alumino silicate glass	<30%
			Polymerizable dimethacrylate resins	<20%
			Bis-GMA	<20%
			NaF	<5%
			Dipentaerythritol pentaacrylate phosphate	<5%
13	Fissurit FX	VOCO GmbH, Cuxhaven Germany	Bis-GMA	91%	[35,36]
			UDMA
			Borosilicate glass	3%
			NaF
14	BeautiSealant	Shofu, Kyoto, Japan	Surface pre-reacted glass-ionomer	30%	[30,36,37]
			FS	—
			UDMA	—
			TEGDMA	—
15	PermaSeal	Ultradent Products, South Jordan, Utah, USA	Bis-GMA	60%	[38,39]
			TEGDMA	<40%
			DMAEMA	<3%
16	CosmeSeal Filled	Deltamed GmbH., Friedberg,Germany	UDMA	10–40%	[40]
			Bis-GMA	10–30%
			BDDMA	<25%
17	RE-GEN™ Pit and Fissure Sealant	Inter-Med, Inc./Vista Dental Products, Racine, Wisconsin, USA	HEMA	0–30%	[41]
			HMPP	0.5–1.5%
			TPO	0.5–1.5%
			EDB	0.5–1.5%
			UDMA	0–70%
			MDP	0–20%
			FS	0–10%
18	HEXA PIT & FISSURE SEALANT – VISIBLE LIGHT CURE	Hexa Denal, East Washington Blvd., California, USA	Bis-GMA	<32%	[42]
			TEGDMA	<37%
			GPTA	<26%
			Inorganic filler	<4.5%
			EDB	<2.0%
19	OMNICHROMA	Tokuyama Dental Corporation, Tokyo, Japan	Ceramic-composite filler	79%	[43,44]
			UDMA	—
			TEGDMA	—
			HQMME	—
			BHT	—
			UV absorber	—
20	Grandio Seal	VOCO GmbH, Cuxhaven, Germany	TEGDMA	10–25%	[30,45]
			FS	5–10%
			Bis-GMA	2.5–5%
21.1	Ionoseal	VOCO GmbH, Cuxhaven, Germany	Bis-GMA	—	[46]

			BHT	—
			Ionomer glass	—
21.2	Ionoseal	VOCO GmbH, Cuxhaven, Germany	Fluoroalminumsilicate	—	[47]
			Bis-GMA	—
			HEMA	—
			TEGDMA	—
			CQ	—
			Amine	—
22	Fissurit	VOCO GmbH, Cuxhaven, Germany	Bis-GMA	—	[48,49]
			UDMA	—
			BHT	—
			Benzotriazol derivative	—
23.1	Fissurit F	VOCO GmbH, Cuxhaven, Germany	Bis-GMA	—	[49]
			UDMA	—
			BHT	—
			Benzotriazol derivative	—
			NaF	—
23.2	Fissurit F	VOCO GmbH, Cuxhaven, Germany	Bis-GMA	—	[48]
			Bis-EMA	—
			UDMA	—
			BHT	—
			Benzotriazol derivative	—
			TEGDMA	—
			NaF	—
24	Smartseal & loc F	DETAX GmbH & Co, Ettingen, Germany	Bis-HEMA phosphate	<15%	[50,51]
			Unspecified HEMA phosphate	<10%
			DMAEMA	<5%
			TMPTMA	<5%
			Padimate O	<1%
			TEGDMA	<1%
25	Smartseal & loc	DETAX GmbH & Co, Ettingen, Germany	Bis-HEMA phosphate	<15%	[51]
			Unspecified HEMA phosphate	<10%
			DMAEMA	<5%
			TMPTMA	<5%
			Padimate O	<1%
			TEGDMA	<1%
26.1	Seal.it Light-Cured Pit and Fissure Sealant	Spident Co., Ltd., Seoul, South Korea	Bis-EMA	—	[52]
			TEGDMA	—
			UDMA	—
			Micro/Nano silica	—
			Initiator	—
			Catalyst	—
			Stabilizer	—
			Others	—
26.2	Seal.it Light-Cured Pit and Fissure Sealant	Spident Co., Ltd., Seoul, South Korea	Bis-EMA	30–50%	[53]
			TEGDMA	20–30%
27	Light Bond Sealant without Fluoride	RELIANCE, Alsip IL, USA	UDMA	30–50%	[54]
			TEGDMA	10–30%
			Bis-GMA	10–30%
			THFMA	10–20%
28	Light Bond Sealant with Fluoride	RELIANCE, Alsip IL, USA	UDMA	30–50%	[54]
			TEGDMA	10–30%
			Bis-GMA	10–30%
			THFMA	10–20%
			Fluorinated Methacrylate Monomer	1–5%
29	ACCLEAN	Henry Schein, Melville, NY, US	HEMA	>0–30%	[55]
			HMPP	0.5–1.5%
			TPO	0.5–0.5%
			EDB	0.5–1.5%
			UDMA	>0–70%
30.1	UltraSeal XT hydro	Ultradent Products, Utah, USA	TEGDMA	<20%	[56]
			UDMA	<8%
			Al₂O₃	<4%
			MA	<1%
			TiO₂	<0.3%
			SMFP	<0.2%
30.2	UltraSeal XT hydro	Ultradent Products, Utah, USA	TEGDMA	10–30%	[57]
			UDMA	5–20%
			Trade Secret	1–10%
			TiO₂	1–10%
			MA	<1%
			Organophosphine Oxide	<1%
31	PF Seal	Prevest DenPro Limited, Bari-Brahmana, India	UDMA	—	[58]
			TEGDMA	—
			Silanated barium glass	—
			Glass powder	—
			FS	—
			Curing agents	—
			Stabilizer	—
32	Defense-Chroma	Angelus, Lindoia, Brasil	Bis-GMA	—	[59]
			Modified urethane	—
			TEGDMA	—
			Barium aluminum borosilicate	—
			Tetra-acrylic ester	—
			H₃PO₄	—
			NaF	—
			MDEA	—
			CQ	—
33	TeEconom Plus Sealant	Ivoclar Vivadent AG, Schaan, Liechtenstein	Dimethacrylates	22 wt%	[60]
			TEGDMA
			Barium glass	76 wt% or 60 vol%
			YbF₃
			SiO₂
			Mixed oxides
			Additives	2 wt%
34	BioCoat Bioactive Pit and Fissure Sealant	Premier Dental Products Company, 1710 Romano Dr, Plymouth Meeting, PA 19462, USA	Barrium aluminoborosilicate	<60%	[61,62,63]
			TEGDMA	—
			Calcium donor	<2%
			Phosphate donor	—
			FS	—
			Photoinitiator	<2.5%
			Bis-GMA	—
35	Alpha-seal light cure pit & Fissure Sealant	Dental Technologies, inc., 6901 N. Hamlin Avenue, Lincolnwood, Illinois 60712, USA	Barium-alumino-silicate glass containing fluoride	45–55%	[64]
			Methacrylate monomers	45–55%
			Accelerator	<1%
			Photoinitiator	<1%
			UV stabilizer	<1%
			Colorant	<1%
36	Enamel loc	Premier Dental Products Company, REV, USA	UDMA	—	[65,66]
			TEGDMA	—
			Methacrylated phosphoric acid esters	—
			4-MET	—
			Photoinitiators	—
			TiO₂	—
			FS	—
37	SEAL & PROTECT™ Protective Sealant for Exposed Dentin	Dentsply Sirona, York, PA, USA	Acetone	40–50 wt%	[67]
			Urethane dimethyl resin	20–30 wt%
			Dipentarythritol pentaacrylate phosphate	10–20 wt%
			TMPTMA	1–10 wt%
			Triclosan	1–5 wt%
38	Eco-S	Vericom Co., Ltd., Republic of Korea	Bis-GMA	50–55%	[68]
			FS	5–9%
			TEGDMA	35–40%
39	PREVENT SEAL	ITENA CLINICAL, Paris, France	UDMA	50–75%	[69]
			DEGDMA	25–50%
			HEMA–phthalate derivative	0–10%
			Glass	0–10%
			Oxide
			Chemicals
			Unspecified HEMA phosphate	0–10%
			EDB	0–5%
			CQ	0–5%
40	Arkona Flow-color	Arkona, Nasutów, Poland	Bis-GMA	—	[70]
			TEGDMA	—
			UDMA	—
			Bis-EMA	—
			Barium–alumino-borosilicate glass	—
			Fluoroaluminosilicate barium glass	—
			FS	—
			Pigments	—
41	Flow-it ALC	Pentron, Orange, CA, USA	EGDMA	10–30%	[71]
			PEG	10–30%
			HALS 292	0.1–1%

Source: Author’s contribution, references indicated.

Heatmap with a dendrogram depicting the results of sealant clustering based on similarities in composition of monomers. Blue indicates the presence and white indicates the absence of an ingredient. The dendrogram on the left indicates possible sealant groups. Sealants linked into one branch of the dendrogram have a similar composition. Distance from the tree increases with increasing differences.

Heatmap with a dendrogram depicting the results of sealant clustering based on similarities in composition of various additives. Blue indicates the presence and white indicates the absence of an ingredient. The dendrogram on the left indicates possible sealant groups. Sealants linked into one branch of the dendrogram have a similar composition. Distance from the tree increases with increasing differences.

Table 2

Fluoride presence in the identified sealants formulations with information of its quantity and source

No.	Product Name	Presence	Quantity	Source	Reference
1.1	Embrace Wet Bond	Yes	<2%	NaF	[16]
1.2	Embrace Wet Bond	Yes	Not disclosed	NaF	[17]
2	Fotoseal	Yes	Not disclosed	Eutectic fluoride	[17,18]
3.1	3M Clinpro Sealant	Yes	<5%	TBATFB	[19]
3.2	3M Clinpro Sealant	Yes	Not disclosed	TBATFB	[20]
4.1	UltraSeal XT Plus	No/not disclosed	—	—	[21]
4.2	UltraSeal XT Plus	Yes	<1%	SMFP	[22]
5	SEAL-RITE PIT AND FISSURE SEALANT	Yes	<2%	NaF	[23]
6	Helioseal	No/not disclosed	—	—	[24,25]
7.1	Helioseal F	Yes	Not disclosed	Fluorosilicate glass	[24]
7.2	Helioseal F	Yes	Not disclosed	Fluorosilicate glass	[26]
8	Helioseal Clear	No/not disclosed	—	—	[24,27]
9.1	Conseal F	Yes	0.01%	NaF	[28,29]
9.2	Conseal F	No/not disclosed	—	—	[30]
10.1	GUARDIAN SEAL	No/Not disclosed	—	—	[31]
10.2	GUARDIAN SEAL	Yes	Not disclosed	Fluoride releasing monomer: BF3	[32]
11.1	DELTON Plus Light Cure Opaque Sealant	Yes	1–2%	Sodium fluoride	[33]
11.2	DELTON Plus Light Cure Opaque Sealant	No/not disclosed	—	—	[22]
12	FluroShield VLC	Yes	<5%	NaF	[22,34]
13	Fissurit FX	Yes	3%	Borosilicate glass fluoride – NaF	[35,36]
14	BeautiSealant	Yes	30%	Surface pre-reacted glass-ionomer	[30,36,37]
15	PermaSeal	No/not disclosed	—	—	[38,39]
16	CosmeSeal Filled	No/not disclosed	—	—	[40]
17	RE-GEN™ Pit and Fissure Sealant	No/not disclosed	—	—	[41]
18	HEXA PIT & FISSURE SEALANT – VISIBLE LIGHT CURE	No/not disclosed	—	—	[42]
19	OMNICHROMA	No/not disclosed	—	—	[43,44]
20	Grandio Seal	No/not disclosed	—	—	[30,45]
21.1	Ionoseal	Yes	Not disclosed	Ionomer glass	[46]
21.2	Ionoseal	Yes	Not disclosed	Fluoroaluminosilicate	[47]
22	Fissurit	No/not disclosed	—	—	[48,49]
23.1	Fissurit F	Yes	Not disclosed	NaF	[49]
23.2	Fissurit F	Yes	Not disclosed	NaF	[48]
24	Smartseal & loc F	Yes	Not disclosed	Composite-based, hydrophilic, with fluoride	[50,51]
25	Smartseal & loc	No/not disclosed	—	—	[51]
26.1	Seal.it Light-Cured Pit and Fissure Sealant	No/not disclosed	—	—	[52]
26.2	Seal.it Light-Cured Pit and Fissure Sealant	No/not disclosed	—	—	[53]
27	Light Bond Sealant without Fluoride	No/not disclosed	—	—	[54]
28	Light Bond Sealant with Fluoride	Yes	1–5%	Fluorinated methacrylate monomer	[54]
29	ACCLEAN	No/not disclosed	—	—	[55]
30.1	UltraSeal XT hydro	Yes	<0.2%	SMFP	[56]
30.2	UltraSeal XT hydro	No/not disclosed	—	—	[57]
31	PF Seal	No/not disclosed	—	—	[58]
32	Defense-Chroma	Yes	Not disclosed	NaF	[59]
33	TeEconom Plus Sealant	No/not disclosed	—	—	[60]
34	BioCoat Bioactive Pit and Fissure Sealant	No/not disclosed	—	—	[61,62,63]
35	Alpha-seal light Cure Pit & Fissure Sealant	Yes	45–55%	Barium-alumino-silicate glass containing fluoride	[64]
36	Enamel loc	No/not disclosed	—	—	[65,66]
37	SEAL & PROTECT™ Protective Sealant for Exposed Dentin	No/not disclosed	—	—	[67]
38	Eco-S	No/not disclosed	—	—	[68]
39	PREVENT SEAL	No/not disclosed	—	—	[69]
40	Arkona Flow-Color	Yes	Not disclosed	Fluoroaluminosilicate barium glass	[70]
41	Flow-It ALC	No/not disclosed	—	—	[71]

Source: Author’s contribution, references indicated.

Articles in this issue

DOI: https://doi.org/10.2478/msp-2026-0006 | Journal eISSN: 2083-134X (formerly 2083-124X) | Journal ISSN: 2083-1331

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Language: English

Page range: 83 - 107

Submitted on: Feb 5, 2026

Accepted on: Mar 29, 2026

Published on: Apr 22, 2026

Published by: Wroclaw University of Science and Technology

In partnership with: Paradigm Publishing Services

Keywords:

Dental sealants,

Dental sealants formulations,

Composition analysis,

Related subjects:

Materials sciences, other,

Nanomaterials,

Functional and smart materials,

Materials characterization and properties

© 2026 Paweł J. Piszko, Paulina Drapiewska, Julia Kurczyk, Natalia Stelmaszczyk, Michał J. Kulus, Aleksandra Piszko, Maciej Dobrzyński, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 44 (2026): Issue 1 (March 2026)

Integrative review of resin-based dental pit and fissure sealants: Composition analysis and a novel categorization proposal

Figures & Tables

Figure 1

Figure 2

Table 1

Figure 3

Figure 4

Table 2

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