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Integrative review of resin-based dental pit and fissure sealants: Composition analysis and a novel categorization proposal Cover

Integrative review of resin-based dental pit and fissure sealants: Composition analysis and a novel categorization proposal

Materials Science-Poland
Volume 44 (2026): Issue 1 (March 2026)
By: ,  ,  ,  ,  ,   and    
Open Access
|Apr 2026
Figures & tables

Figures & Tables

Figure 1

Graphical illustration of the operation principle of dental sealants.

Figure 2

Bubble heatmap depicting the classification of the rarity of ingredients identified in the dental sealant formulations and the size of each group.

Figure 3

Heatmap with a dendrogram depicting the results of sealant clustering based on similarities in composition of monomers. Blue indicates the presence and white indicates the absence of an ingredient. The dendrogram on the left indicates possible sealant groups. Sealants linked into one branch of the dendrogram have a similar composition. Distance from the tree increases with increasing differences.

Figure 4

Heatmap with a dendrogram depicting the results of sealant clustering based on similarities in composition of various additives. Blue indicates the presence and white indicates the absence of an ingredient. The dendrogram on the left indicates possible sealant groups. Sealants linked into one branch of the dendrogram have a similar composition. Distance from the tree increases with increasing differences.

Fluoride presence in the identified sealants formulations with information of its quantity and source

No.Product NamePresenceQuantitySourceReference
1.1Embrace Wet BondYes<2%NaF[16]
1.2Embrace Wet BondYesNot disclosedNaF[17]
2FotosealYesNot disclosedEutectic fluoride[17,18]
3.13M Clinpro SealantYes<5%TBATFB[19]
3.23M Clinpro SealantYesNot disclosedTBATFB[20]
4.1UltraSeal XT PlusNo/not disclosed——[21]
4.2UltraSeal XT PlusYes <1%SMFP[22]
5SEAL-RITE PIT AND FISSURE SEALANTYes <2%NaF[23]
6HeliosealNo/not disclosed——[24,25]
7.1Helioseal FYesNot disclosedFluorosilicate glass[24]
7.2Helioseal FYesNot disclosedFluorosilicate glass[26]
8Helioseal ClearNo/not disclosed——[24,27]
9.1Conseal FYes0.01%NaF[28,29]
9.2Conseal FNo/not disclosed——[30]
10.1GUARDIAN SEALNo/Not disclosed——[31]
10.2GUARDIAN SEALYesNot disclosedFluoride releasing monomer: BF3[32]
11.1DELTON Plus Light Cure Opaque SealantYes1–2%Sodium fluoride[33]
11.2DELTON Plus Light Cure Opaque SealantNo/not disclosed——[22]
12FluroShield VLCYes<5%NaF[22,34]
13Fissurit FXYes3%Borosilicate glass fluoride – NaF[35,36]
14BeautiSealantYes30%Surface pre-reacted glass-ionomer[30,36,37]
15PermaSealNo/not disclosed——[38,39]
16CosmeSeal FilledNo/not disclosed——[40]
17RE-GEN™ Pit and Fissure SealantNo/not disclosed——[41]
18HEXA PIT & FISSURE SEALANT – VISIBLE LIGHT CURENo/not disclosed——[42]
19OMNICHROMANo/not disclosed——[43,44]
20Grandio SealNo/not disclosed——[30,45]
21.1IonosealYesNot disclosedIonomer glass[46]
21.2IonosealYesNot disclosedFluoroaluminosilicate[47]
22FissuritNo/not disclosed——[48,49]
23.1Fissurit FYesNot disclosedNaF[49]
23.2Fissurit FYesNot disclosedNaF[48]
24Smartseal & loc FYesNot disclosedComposite-based, hydrophilic, with fluoride[50,51]
25Smartseal & locNo/not disclosed——[51]
26.1Seal.it Light-Cured Pit and Fissure SealantNo/not disclosed——[52]
26.2Seal.it Light-Cured Pit and Fissure SealantNo/not disclosed——[53]
27Light Bond Sealant without FluorideNo/not disclosed——[54]
28Light Bond Sealant with FluorideYes1–5%Fluorinated methacrylate monomer[54]
29ACCLEANNo/not disclosed——[55]
30.1UltraSeal XT hydroYes <0.2%SMFP[56]
30.2UltraSeal XT hydroNo/not disclosed——[57]
31PF SealNo/not disclosed——[58]
32Defense-ChromaYesNot disclosedNaF[59]
33TeEconom Plus SealantNo/not disclosed——[60]
34BioCoat Bioactive Pit and Fissure SealantNo/not disclosed——[61,62,63]
35Alpha-seal light Cure Pit & Fissure SealantYes45–55%Barium-alumino-silicate glass containing fluoride[64]
36Enamel locNo/not disclosed——[65,66]
37SEAL & PROTECT™ Protective Sealant for Exposed DentinNo/not disclosed——[67]
38Eco-SNo/not disclosed——[68]
39PREVENT SEALNo/not disclosed——[69]
40Arkona Flow-ColorYesNot disclosedFluoroaluminosilicate barium glass[70]
41Flow-It ALCNo/not disclosed——[71]

Composition of identified dental pit and fissure sealants with respective quantity of ingredients_

No.Product NameManufacturerChemical compoundQuantityReference
1.1Embrace Wet BondPulpdent Corporation, Watertown, Massachusetts, USAUncured acrylate ester monomers55–60%[16]
FS5%
NaF<2%
1.2Embrace Wet BondPulpdent Corporation, Watertown, Massachusetts, USAAliphatic urethane dimethacrylate—[17]
Bis-methacryloyl phosphate—
HEMA—
TMPTMA—
H2O
NaF—
SiO2 —
2FotosealRemed Prodimpex SRL, Bucharest, RomaniaDimethacrylate monomer mixture60%[17,18]
Colloidal silica40%
TiO2
Eutectic fluoride
3.13M Clinpro Sealant3M, St. Paul, Minnesota, USABis-GMA40–50%[19]
TEGDMA40–50%
Silane-treated silica5–10%
TBATFB<5%
DPIHFP<1%
TiO2 <0.5%
SbPh3 <0.5%
EDB<0.3%
HQ<0.05%
3.23M Clinpro Sealant3M, St. Paul, Minnesota, USATEGDMA—[20]
Bis-GMA—
TBATFB—
Dichloride methylsilane—
Silica6%
Dye—
4.1UltraSeal XT PlusUltradent Products inc, South Jordan, Utah, USATEGDMA>10–≤25%[21]
UDMA1–10%
HEMA≥0.1–<1%
Trade Secret≥0.1–<1%
4.2UltraSeal XT PlusUltradent Products inc, South Jordan, Utah, USAUDMA<10%[22]
Bis-GMA<20%
DMAEMA<1%
SMFP<1%
TiO2 <1%
Fillers58%
5SEAL-RITE PIT AND FISSURE SEALANTPulpdent Corporation, Watertown, Massachusetts, USAUncured acrylate ester monomers55–65%[23]
FS5%
NaF<2%
6HeliosealIvoclar Vivadent, Schaan, LichtensteinBis-GMA58.30%[24,25]
TEGDMA38.1%
TiO2 2.1%
Catalysts1.6%
Stabilizers
7.1Helioseal FIvoclar Vivadent, Schaan, LichtensteinBis-GMA11.8%[24]
TEGDMA23.40%
UDMA23.40%
Fluorosilicate glass40.50%
SiO2
TiO2 0.6%
Stabilizers0.3%
Catalysts
7.2Helioseal FIvoclar Vivadent, Schaan, LichtensteinBis-GMA—[26]
UDMA—
TEGDMA—
Fluorosilicate glass20%
SiO2 21.5%
8Helioseal ClearIvoclar Vivadent, Schaan, LichtensteinBig-GMA60.0%[24,27]
TEGDMA39.3%
Stabilizers0.7%
Catalysts
9.1Conseal FSDI, Victoria, AustraliaAcrylic monomer93%[28,29]
Silica7%
TiO2 0.01%
NaF0.01%
9.2Conseal FSDI, Victoria, AustraliaUDMA50–70%[30]
10.1GUARDIAN SEALKerr corporation, Orange, California, USAUncured methacrylate ester monomers60–65%[31]
Mineral fillers—
Photoinitiators—
Stabilizing additives—
10.2GUARDIAN SEALKerr corporation, Orange, California, USAFluoride releasing monomer: BF3—[32]
Bis-GMA—
CQ—
Silica—
11.1DELTON Plus Light Cure Opaque SealantDENTSPLY Professional, York, USAResin blend55–65%[33]
Silanated milled glass30–40%
NaF1–2%
TiO2 <1%
11.2DELTON Plus Light Cure Opaque SealantDENTSPLY Professional, York, USAAromatic and aliphatic dimethacrylate91.20%[22]
TiO2 1.50%
SiO2 5.40%
EDB1.00%
Light activators>1%
12FluroShield VLCDentsply Sirona, Milford, USAUrethane modified Bis-GMA dimethacrylate<40%[22,34]
Barium boron alumino silicate glass<30%
Polymerizable dimethacrylate resins<20%
Bis-GMA<20%
NaF<5%
Dipentaerythritol pentaacrylate phosphate<5%
13Fissurit FXVOCO GmbH, Cuxhaven GermanyBis-GMA91%[35,36]
UDMA
Borosilicate glass3%
NaF
14BeautiSealantShofu, Kyoto, JapanSurface pre-reacted glass-ionomer30%[30,36,37]
FS—
UDMA—
TEGDMA—
15PermaSealUltradent Products, South Jordan, Utah, USABis-GMA60%[38,39]
TEGDMA<40%
DMAEMA<3%
16CosmeSeal FilledDeltamed GmbH., Friedberg,GermanyUDMA10–40%[40]
Bis-GMA10–30%
BDDMA<25%
17RE-GEN™ Pit and Fissure SealantInter-Med, Inc./Vista Dental Products, Racine, Wisconsin, USAHEMA0–30%[41]
HMPP0.5–1.5%
TPO0.5–1.5%
EDB0.5–1.5%
UDMA0–70%
MDP0–20%
FS0–10%
18HEXA PIT & FISSURE SEALANT – VISIBLE LIGHT CUREHexa Denal, East Washington Blvd., California, USABis-GMA<32%[42]
TEGDMA<37%
GPTA<26%
Inorganic filler<4.5%
EDB<2.0%
19OMNICHROMATokuyama Dental Corporation, Tokyo, JapanCeramic-composite filler79%[43,44]
UDMA—
TEGDMA—
HQMME—
BHT—
UV absorber—
20Grandio SealVOCO GmbH, Cuxhaven, GermanyTEGDMA10–25%[30,45]
FS5–10%
Bis-GMA2.5–5%
21.1IonosealVOCO GmbH, Cuxhaven, GermanyBis-GMA—[46]
BHT—
Ionomer glass—
21.2IonosealVOCO GmbH, Cuxhaven, GermanyFluoroalminumsilicate—[47]
Bis-GMA—
HEMA—
TEGDMA—
CQ—
Amine—
22FissuritVOCO GmbH, Cuxhaven, GermanyBis-GMA—[48,49]
UDMA—
BHT—
Benzotriazol derivative—
23.1Fissurit FVOCO GmbH, Cuxhaven, GermanyBis-GMA—[49]
UDMA—
BHT—
Benzotriazol derivative—
NaF—
23.2Fissurit FVOCO GmbH, Cuxhaven, GermanyBis-GMA—[48]
Bis-EMA—
UDMA—
BHT—
Benzotriazol derivative—
TEGDMA—
NaF—
24Smartseal & loc FDETAX GmbH & Co, Ettingen, GermanyBis-HEMA phosphate<15%[50,51]
Unspecified HEMA phosphate<10%
DMAEMA<5%
TMPTMA<5%
Padimate O<1%
TEGDMA<1%
25Smartseal & locDETAX GmbH & Co, Ettingen, GermanyBis-HEMA phosphate<15%[51]
Unspecified HEMA phosphate<10%
DMAEMA<5%
TMPTMA<5%
Padimate O<1%
TEGDMA<1%
26.1Seal.it Light-Cured Pit and Fissure SealantSpident Co., Ltd., Seoul, South KoreaBis-EMA—[52]
TEGDMA—
UDMA—
Micro/Nano silica—
Initiator—
Catalyst—
Stabilizer—
Others—
26.2Seal.it Light-Cured Pit and Fissure SealantSpident Co., Ltd., Seoul, South KoreaBis-EMA30–50%[53]
TEGDMA20–30%
27Light Bond Sealant without FluorideRELIANCE, Alsip IL, USAUDMA30–50%[54]
TEGDMA10–30%
Bis-GMA10–30%
THFMA10–20%
28Light Bond Sealant with FluorideRELIANCE, Alsip IL, USAUDMA30–50%[54]
TEGDMA10–30%
Bis-GMA10–30%
THFMA10–20%
Fluorinated Methacrylate Monomer1–5%
29ACCLEANHenry Schein, Melville, NY, USHEMA>0–30%[55]
HMPP0.5–1.5%
TPO0.5–0.5%
EDB0.5–1.5%
UDMA>0–70%
30.1UltraSeal XT hydroUltradent Products, Utah, USATEGDMA<20%[56]
UDMA<8%
Al2O3 <4%
MA<1%
TiO2 <0.3%
SMFP<0.2%
30.2UltraSeal XT hydroUltradent Products, Utah, USATEGDMA10–30%[57]
UDMA5–20%
Trade Secret1–10%
TiO2 1–10%
MA<1%
Organophosphine Oxide<1%
31PF SealPrevest DenPro Limited, Bari-Brahmana, IndiaUDMA—[58]
TEGDMA—
Silanated barium glass—
Glass powder—
FS—
Curing agents—
Stabilizer—
32Defense-ChromaAngelus, Lindoia, BrasilBis-GMA—[59]
Modified urethane—
TEGDMA—
Barium aluminum borosilicate—
Tetra-acrylic ester—
H3PO4 —
NaF—
MDEA—
CQ—
33TeEconom Plus SealantIvoclar Vivadent AG, Schaan, LiechtensteinDimethacrylates22 wt%[60]
TEGDMA
Barium glass76 wt% or 60 vol%
YbF₃
SiO2
Mixed oxides
Additives2 wt%
34BioCoat Bioactive Pit and Fissure SealantPremier Dental Products Company, 1710 Romano Dr, Plymouth Meeting, PA 19462, USABarrium aluminoborosilicate<60%[61,62,63]
TEGDMA—
Calcium donor<2%
Phosphate donor—
FS—
Photoinitiator<2.5%
Bis-GMA—
35Alpha-seal light cure pit & Fissure SealantDental Technologies, inc., 6901 N. Hamlin Avenue, Lincolnwood, Illinois 60712, USABarium-alumino-silicate glass containing fluoride45–55%[64]
Methacrylate monomers45–55%
Accelerator<1%
Photoinitiator<1%
UV stabilizer<1%
Colorant<1%
36Enamel locPremier Dental Products Company, REV, USAUDMA—[65,66]
TEGDMA—
Methacrylated phosphoric acid esters—
4-MET—
Photoinitiators—
TiO₂—
FS—
37SEAL & PROTECT™ Protective Sealant for Exposed DentinDentsply Sirona, York, PA, USAAcetone40–50 wt%[67]
Urethane dimethyl resin20–30 wt%
Dipentarythritol pentaacrylate phosphate10–20 wt%
TMPTMA1–10 wt%
Triclosan1–5 wt%
38Eco-SVericom Co., Ltd., Republic of KoreaBis-GMA50–55%[68]
FS5–9%
TEGDMA35–40%
39PREVENT SEALITENA CLINICAL, Paris, FranceUDMA50–75%[69]
DEGDMA25–50%
HEMA–phthalate derivative0–10%
Glass0–10%
Oxide
Chemicals
Unspecified HEMA phosphate0–10%
EDB0–5%
CQ0–5%
40Arkona Flow-colorArkona, Nasutów, PolandBis-GMA—[70]
TEGDMA—
UDMA—
Bis-EMA—
Barium–alumino-borosilicate glass—
Fluoroaluminosilicate barium glass—
FS—
Pigments—
41Flow-it ALCPentron, Orange, CA, USAEGDMA10–30%[71]
PEG10–30%
HALS 2920.1–1%
DOI: https://doi.org/10.2478/msp-2026-0006 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
Journal RSS Feed
Language: English
Page range: 83 - 107
Submitted on: Feb 5, 2026
Accepted on: Mar 29, 2026
Published on: Apr 22, 2026
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Dental sealants,
Dental sealants formulations,
Composition analysis,
Integrative review,
Fluoride,
Caries prevention
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2026 Paweł J. Piszko, Paulina Drapiewska, Julia Kurczyk, Natalia Stelmaszczyk, Michał J. Kulus, Aleksandra Piszko, Maciej Dobrzyński, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 44 (2026): Issue 1 (March 2026)
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