Have a personal or library account? Click to login
AD-HOLDER: Alzheimer’s Disease Detection via Machine Learning based Histograms of Light GBM Classifier using MRI and PET Images Cover

AD-HOLDER: Alzheimer’s Disease Detection via Machine Learning based Histograms of Light GBM Classifier using MRI and PET Images

By: S Mahalakshmi and  K Valarmathi  
Open Access
|Dec 2025

Figures & Tables

Fig. 1.

The proposed AD-HOLDER methodology.

Fig. 2.

Architecture diagram of the HOG-based LGBM model.

Fig. 3.

Visual examples of segmented regions.

Fig. 4.

Experimental results of the proposed AD-HOLDER methodology.

Fig. 5.

Performance analysis for two-class classification.

Fig. 6.

ACC curve for the proposed AD-HOLDER model.

Fig. 7.

Loss curve for the proposed AD-HOLDER model.

Fig. 8.

CM for two-class classification.

Fig. 9.

ROC curve of the proposed AD-HOLDER classification model.

Fig. 10.

Comparison results of different segmentation techniques.

Fig. 11.

Real-time clinical setting of the proposed AD-HOLDER model.

Comparative analysis between traditional ML networks_

TechniquesACCSPEPRERECF1
KNN90.6389.3990.3785.9287.93
CNN93.9594.2192.4987.3790.62
Naive Bayes92.8491.8388.9386.7589.51
Decision Tree93.9293.7294.9388.2392.73
ViT96.3892.6394.2690.1895.29
RF95.2995.9095.2791.3594.62
LGBM99.1297.7997.5792.6096.55

Quantitative comparison of denoising methods on MRI and PET images_

MethodPSNR [dB]SSIM
Median filter27.420.712
Gaussian filter28.060.815
Bilateral filter28.750.822
NLM filter29.740.858
DIP (proposed)31.820.917

Comparison of traditional segmentation algorithms [%]_

MethodsACCDIIoU
U-net91.3771.8258.2
V-net93.7581.4669.9
Nested V-net95.0184.2872.9
SegNet92.3786.1073.5
GBS (ours)99.1290.7482.7

Hyperparameter settings of the LGBM classifier_

Hyper parameterValue
Number of estimators500
Learning rate0.05
Maximum depth8
Feature fraction0.8
λL1(L1 reg)0.1
λL2(L2 reg)0.2
Cross-validation folds3 and 5

Comparison of existing models and the proposed AD-HOLDER model_

AuthorsMethodsACC [%]PRE [%]REC [%]F1 [%]p-value
Battineni, G. [14]GBA97.5894.8988.2690.360.041
Odusami, M., et al. [16]XAI73.9092.6785.2988.820.37
Hamdi, M. [19]CNN96.0095.9290.5193.520.42
Proposed modelAD-HOLDER model99.1297.5792.6096.550.029

Cross-validation results of the proposed AD-HOLDER model_

Metric3-fold cross-validation [%]5-fold cross-validation [%]
ACC98.2798.59
SPE96.8096.14
PRE96.1796.73
REC89.2790.83
F194.6894.91

Efficiency assessment of the proposed AD-HOLDER model_

ClassesACCSPEPRERECF1
Normal98.9698.4296.8389.7395.38
Abnormal99.2997.1798.3295.4897.72
Language: English
Page range: 389 - 399
Submitted on: Oct 1, 2024
|
Accepted on: Sep 29, 2025
|
Published on: Dec 23, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2025 S Mahalakshmi, K Valarmathi, published by Slovak Academy of Sciences, Institute of Measurement Science
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.