Have a personal or library account? Click to login
Isolation, characterization, and biological activity of ethanolic extracts from dandelion (Taraxacum officinale) root Cover

Isolation, characterization, and biological activity of ethanolic extracts from dandelion (Taraxacum officinale) root

Open Access
|Dec 2025

References

  1. Aung T, Das SK 2025. Quantitative investigation of total phenolics content in spray-dried dandelion extract powder. Int J Environ Sci 11(4S): 600-607
  2. Álvarez-Romero M, Ruíz-Rodríguez A, Barbero GF, Vázquez-Espinosa M, El-Mansouri F, Brigui J, Palma M 2023. Comparison between ultrasound- and microwave-assisted extraction methods to determine phenolic compounds in barley (Hordeum vulgare L.) Foods 12(14): 2638
  3. Azmir J, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena F, Jahurul MHA, Ghafoor K, Norulaini NAN, Omar AKM 2013. Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering, 117(4), 426–436.
  4. Babayan B, Yesayan A, Sevoyan G, Yesayan T 2025. Genetic changes in common dandelion (Taraxacum officinale) induced by high concentrations of heavy metals in soil. Funct Food Health Dis 15(9): 625-633
  5. Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO, Gurun MS 2013. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. J Nat Med 67(4): 698-704.
  6. Başaran E, Öztürk AA, Şenel B, Demirel M, Sarica Ş 2022. Quercetin, rutin and quercetin-rutin incorporated hydroxypropyl β-cyclodextrin inclusion complexes. Eur J Pharm Sci 1:172:106153.
  7. Bouaoudia-Madi N, Boulekbache-Makhlouf L, Madani K, Silva AMS, Dairi S, Oukhmanou–Bensidhoum S, Cardoso S 2019. Optimization of ultrasound-assisted extraction of polyphenols from Myrtus communis L. pericarp. Antioxidants (Basel) 2:8(7):205.
  8. Clifford MN, Johnston KL, Knight S, Kuhnert N 2003. Hierarchical scheme for LC-MSn identification of chlorogenic acids. J Agric Food Chem 51(10) 2900-2911.
  9. Cogger CG 2005. Potential compost benefits for restoration of soils disturbed by urban development. Compost Sci Util 13: 243-251.
  10. Djingova R, Kuleff I 1993. Monitoring of heavy metal pollution by Taraxacum officinale. Wiley-VCH Verlag GmbH: 435-460.
  11. Escudero NL, De Arellano ML, Fernández S, Albarracín G, Mucciarelli S 2003. Taraxacum officinale as a food source. Plant Foods Hum Nutr 58: 1-10.
  12. Guojun D, Yuxuan L, Sen F, Cuntang W 2025. Microwave-assisted extraction of dandelion root polysaccharides: extraction process optimization, purification, structural characterization, and analysis of antioxidant activity. Int J Biol Macromol 299:139732.
  13. Hulea C, Obistioiu D, Hulea A, Suleiman MA, Floares Oarga D, Alexa E, Imbrea IM, Neacșu AG, Pentea M, Popescu CA, Imbrea F 2025. Integrated assessment of antibacterial activity, polyphenol composition, molecular docking, and ADME properties of Romanian oak and fir honeydew honeys. Antibiotics (Basel) 14(6): 592.
  14. Iwashina T, Smirnov S, Damdinsuren O, Kondo K 2012. Flavonoids from Reaumuria soongarica (Tamaricaceae) in Mongolia. Bull Natl Mus Nat Sci Ser.B, 38(4) 189-195
  15. Kabata-Pendias A, Dudka S 1991: Trace metal contents; Taraxacum officinale (dandelion) as a convenient environmental indicator. Environ Geochem Health 13: 108-113
  16. Kenny O, Smyth TJ, Hewage CM, Brunton NP 2014. Antioxidant properties and quantitative UPLC-MS/MS analysis of phenolic compounds in dandelion (Taraxacum officinale) root extracts. Free Rad Antiox 4(1):55-61.
  17. Keane B, Collier MH, Shann JR, Rogstad SH 2001: Metal content of dandelion (Taraxacum officinale) leaves in relation to soil contamination and airborne particulate matter. Sci Total Environ 281: 63-78.
  18. Kiss A, Papp VA, Pál A, Prokisch J, Mirani S, Toth BE, Alshaal T. 2025. Comparative study on antioxidant capacity of diverse food matrices: Applicability, suitability and inter-correlation of multiple assays to assess polyphenol and antioxidant status. Antioxidants, 14(3), 317.
  19. Li C, Tian Y, Zhao C, Li S, Wang T, Qiao B, Fu Y 2021. Application of fingerprint combined with quantitative analysis and multivariate chemometric methods in quality evaluation of dandelion (Taraxacum mongolicum). R Soc Open Sci 8: 210614.
  20. Lisiak-Zielińska M, Borowiak K, Budka A, Mleczek P, Cakaj A, Kanclerz J, Hanć A 2025. Seasonal variation of rare earth elements in Taraxacum officinale as an indicator of changes in urban pollution. Sci Rep 15, 29496.
  21. Ma X, Okyere SK, Hu L, Wen J, et al. 2022. Anti-inflammatory activity and mechanism of cryptochlorogenic acid from Ageratina adenophora. Nutrients 14(3), 439.
  22. Maideen NMP, Balasubramanian R, Muthusamy S 2023. A comprehensive review of the pharmacologic perspective on loop diuretic drug interactions with therapeutically used drugs. Curr Drug Metab 23(3): 188-199.
  23. Mikołajczak P, Borowiak K, Niedzielski P 2017. Phytoextraction of rare earth elements in herbaceous plant species growing close to roads. Environ Sci Pollut Res 24: 14091-14103.
  24. Mantzourani C, Kakouri E, Palikaras K, Tarantilis PA, Kokotou MG 2024. Urolithins and their precursors ellagic acid and ellagitannins: natural sources, extraction and methods for their determination. Separations 11(6), 174.
  25. Masike K, Mhlongo MI, Mudau SP, Nobela O, Ncube EN, Tugizimana F, George MJ, Madala NE 2017. Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids. Chem Cent J 11(1): 29.
  26. Navarro M, Moreira I, Arnaez E, Quesada S, Azofeifa G, Vargas F, Alvarado D, Chen P 2017. Flavonoids and ellagitannins characterization, antioxidant and cytotoxic activities of Phyllanthus acuminatus Vahl. Plants 6(4), 62.
  27. Navarro M, Arnaez E, Moreira I, Quesada S, Azofeifa G, Wilhelm K, Vargas F, Chen P 2019. Polyphenolic characterization, antioxidant, and cytotoxic activities of Mangifera indica cultivars from Costa Rica. Foods 8(9), 384.
  28. Oroian M, Dranca F, Ursachi F 2020. Comparative evaluation of maceration, microwave and ultrasonic-assisted extraction of phenolic compounds from propolis. J Food Sci Technol 57: 70-78.
  29. Pacifico S, Piccolella S, Papale F, Nocera P, Lettieri A, Catauro M 2015. A polyphenol complex from Thymus vulgaris L. plants cultivated in the Campania Region (Italy): new perspectives against neuroblastoma. J Functional Foods 20: 253–266.
  30. Peng J, Chen G, Guo S, Lin Z, Li J, Yang W, Xiao G, Wang Q 2024. The galloyl group enhances the inhibitory activity of catechins against LPS-triggered inflammation in RAW264.7 cells. Foods 13(16), 2616.
  31. Pereira AG, Cruz L., Cassani L, Chamorro F, Lourenço-Lopes C, Freitas V, Otero P, Fraga-Corral M, Prieto MA, Simal-Gandara J, Perez-Gregorio R 2023. Comparative study of microwave-assisted extraction and ultrasound-assisted extraction techniques (MAE vs. UAE) for the optimized production of enriched extracts in phenolic compounds of Camellia japonica var. Eugenia de Montijo. Engineering Proceedings, 37(1), 124.
  32. Pooja S, Modi HA 2015. Comparative study of DPPH, ABTS and FRAP assays for determination of antioxidant activity. IJRASET 3(6): 636-641.
  33. Petrovska BB 2012. Historical review of medicinal plants’ usage. Pharmacogn Rev 6: 1-5.
  34. Qiao Q, Song X, Zhang C, Jiang C, Jiang R 2024. Structure and immunostimulating activity of polysaccharides derived from the roots and leaves of dandelion. Chem Biol Technol Agric 11, 51.
  35. Ramesh MM, Shankar NS, Venkatappa AH 2024. Driving/critical factors considered during extraction to obtain bioactive enriched extracts. Pharmacognosy Rev 18(35): 68–81.
  36. Skubic M, Baša Česnik H, Velikonja Bolta Š, Rusjan D, Šircelj H 2025. Is common dandelion (T. officinale agg.) foraged for food pesticide residues free? Foods 14(4): 684.
  37. Spínola V, Pinto J, Castilho PC 2014. Identification and quantification of phenolic compounds of selected fruits from Madeira Island by HPLC-DAD–ESI-MSn and screening for their antioxidant activity. Food Chem 15:173:14-30.
  38. Stanojević Lj, Stanković M, Nikolić V, Nikolić Lj, Ristić D, Čanadanovic-Brunet J, Tumbas V 2009. Antioxidant activity and total phenolic and flavonoid contents of Hieracium pilosella L. extracts. Sensors 9(7): 5702-5714.
  39. Stanojević Lj, Zdravković A, Stanković M, Cakić M, Nikolić V, Ilić D 2013. Antioksidativna aktivnost vodenoetanolnih ekstrakata iz lista koprive (Urtica dioica L.). Savremene tehnologije 2(1): 51-59.
  40. Stewart-Wade SM, Neumann S, Collins LL, Boland GJ 2002. The biology of Canadian weeds. 117. Taraxacum officinale G.H. Weber ex Wiggers. Can J Plant Sci 82: 825-853.
  41. Tanasa Acretei MV, Negreanu-Pirjol T, Olariu L, Negreanu-Pirjol BS, Lepadatu AC, Anghel Cireasa L, Rosoiu N 2025. Bioactive compounds from vegetal organs of Taraxacum species (dandelion) with biomedical applications: a review. Int J Mol Sci 26(2): 450.
  42. Ujević M, Duić Ž, Casiot C, Šipoš L, Santo V, Dadić Ž, Halamić J 2010. Occurrence and geochemistry of arsenic in the groundwater of eastern Croatia. Appl Geochem 25: 1017-1029.
  43. Xuereb M.A, Psakis G, Attard K, Lia F, Gatt R. A 2025. Comprehensive Analysis of Non-Thermal Ultrasonic-Assisted Extraction of Bioactive Compounds from Citrus Peel Waste Through a One-Factor-at-a-Time Approach. Molecules, 30, 648.
  44. Yao J, Ma Z, Wang Y, Wang Y, Sun L, Liu X 2022. Effects of dandelion addition on antioxidant property, sensory characteristics and inhibitory activity against xanthine oxidase of beer. CRFS 5: 927-939.
DOI: https://doi.org/10.2478/mjfst-2025-0003 | Journal eISSN: 1805-529X | Journal ISSN: 1805-5281
Language: English
Page range: 13 - 29
Published on: Dec 15, 2025
Published by: University of Veterinary Sciences Brno
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Milan Mladenović, Sanja Petrović, Jelena Zvezdanović, Aleksandra Milenković, Ljiljana Stanojević, Bojana Danilović, Dragan Cvetković, published by University of Veterinary Sciences Brno
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.