2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment

Ziarani, Ghodsi Mohammadi; Ashtiani, Shadi Tahmasebi; Mohajer, Fatemeh; Badiei, Alireza; Gaikwad, Sunil V.; Varma, Rajender S.

doi:10.2478/cdem-2022-0004

Abstract

The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO₃H and its application was explored as a highly selective fluorescent sensor for Hg²⁺ ion; fluorescence intensity was decreased selectively by Hg²⁺ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg²⁺ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.

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2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment

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