2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment

Ghodsi Mohammadi Ziarani; Shadi Tahmasebi Ashtiani; Fatemeh Mohajer; Alireza Badiei; Sunil V. Gaikwad; Rajender S. Varma

doi:10.2478/cdem-2022-0004

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2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment

Chemistry-Didactics-Ecology-Metrology

Volume 27 (2022): Issue 1-2 (December 2022)

By: Ghodsi Mohammadi Ziarani , Shadi Tahmasebi Ashtiani , Fatemeh Mohajer , Alireza Badiei , Sunil V. Gaikwad and Rajender S. Varma

Open Access

|Feb 2023

Abstract

The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO₃H and its application was explored as a highly selective fluorescent sensor for Hg²⁺ ion; fluorescence intensity was decreased selectively by Hg²⁺ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg²⁺ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.

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Articles in this issue

DOI: https://doi.org/10.2478/cdem-2022-0004 | Journal eISSN: 2084-4506 | Journal ISSN: 1640-9019

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Language: English

Page range: 25 - 33

Published on: Feb 1, 2023

Published by: Society of Ecological Chemistry and Engineering

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

2, 3-dihydro-quinazolin-4(1H)-one,

fluorescent sensor,

SBA-Pr-SO₃H,

Hg²⁺ ion,

sensors

Related subjects:

Chemistry,

Chemistry, other

© 2023 Ghodsi Mohammadi Ziarani, Shadi Tahmasebi Ashtiani, Fatemeh Mohajer, Alireza Badiei, Sunil V. Gaikwad, Rajender S. Varma, published by Society of Ecological Chemistry and Engineering
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 27 (2022): Issue 1-2 (December 2022)