References
- Acharyya, S., Saha, S., Majumder, S., & Bhattacharya, M. (2021). Characterization of a mercury tolerant strain of Staphylococcus arlettae from Darjeeling hills with an account of its antibiotic resistance pattern and metabolome. Archives of Microbiology, 203, 5745-5754.
- Al Azzam, K. M., Negim, E. S., & Aboul-Enein, H. Y. (2022). ADME studies of TUG-770 (a GPR-40 inhibitor agonist) for the treatment of type 2 diabetes using SwissADME predictor: In silico study. Journal of Applied Pharmaceutical Science, 12(4), 159-169.
- Amin, M. L. (2013). P-glycoprotein inhibition for optimal drug delivery. Drug Target Insights, 7, DTIS12519.
- Arabi, M., Nasab, S. H., Lorigooini, Z., Boroujeni, S. N., Mortazavi, S. M., Anjomshoa, M., & Amini-Khoei, H. (2021). Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice. International Immunopharmacology, 93, 107436.
- Bibak, B., Shakeri, F., Barreto, G. E., Keshavarzi, Z., Sathyapalan, T., & Sahebkar, A. (2019). A review of the pharmacological and therapeutic effects of auraptene. BioFactors, 45(6), 867-879.
- Bogaki, T., Mitani, K., Oura, Y., & Ozeki, K. (2017). Effects of ethyl-α-d-glucoside on human dermal fibroblasts. Bioscience, Biotechnology, and Biochemistry, 81(9), 1706-1711.
- Borgström, L. (1998). Local versus total systemic bioavailability as a means to compare different inhaled formulations of the same substance. Journal of Aerosol Medicine, 11(1), 55-63.
- Buels, K. S., & Fryer, A. D. (2012). Muscarinic receptor antagonists: effects on pulmonary function. Muscarinic Receptors, 317-341.
- Chandramoorthi, G. D., Piramanayagam, S., & Marimuthu, P. (2008). An insilico approach to high altitude pulmonary edema-molecular modeling of human β2 adrenergic receptor and its interaction with salmeterol and nifedipine. Journal of Molecular Modeling, 14, 849-856.
- Chauhan, G., Roy, K., Kumar, G., Kumari, P., Alam, S., Kishore, K., Panjwani, U., & Ray, K. (2019). Distinct influence of COX-1 and COX-2 on neuroinflammatory response and associated cognitive deficits during high altitude hypoxia. Neuropharmacology, 146, 138-148.
- Chen, J. F., Eltzschig, H. K., & Fredholm, B. B. (2013). Adenosine receptors as drug targets—what are the challenges?. Nature reviews Drug discovery, 12(4), 265-286.
- Chen, P. Z., He, W. J., Zhu, Z. R., Guo-Ji, E., Xu, G., Chen, D. W., & Gao, Y. Q. (2018a). Adenosine A2A receptor involves in neuroinflammation-mediated cognitive decline through activating microglia under acute hypobaric hypoxia. Behavioural Brain Research, 347, 99-107.
- Chen, C. P., Chen, C. C., Huang, C. W., & Chang, Y. C. (2018b). Evaluating molecular properties involved in transport of small molecules in stratum corneum: A quantitative structure-activity relationship for skin permeability. Molecules, 23(4), 911.
- Choi, S. H., Aid, S., & Bosetti, F. (2009). The distinct roles of cyclooxygenase-1 and-2 in neuroinflammation: implications for translational research. Trends in Pharmacological Sciences, 30(4), 174-181.
- Cieślak, M., Komoszyński, M., & Wojtczak, A. (2008). Adenosine A 2A receptors in Parkinson’s disease treatment. Purinergic Signalling, 4, 305-312.
- Clarke C. (2006). Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia. Postgraduate Medical Journal, 82(973), 748–753. https://doi.org/10.1136/pgmj.2006.047662
- Daina, A., & Zoete, V. (2016). A boiled‐egg to predict gastrointestinal absorption and brain penetration of small molecules. ChemMedChem, 11(11), 1117-1121.
- Ericsson, C. D., Steffen, R., Basnyat, B., Cumbo, T. A., & Edelman, R. (2001). Infections at high altitude. Clinical Infectious Diseases, 33(11), 1887-1891.
- Ferrazzini, G., Maggiorini, M., Kriemler, S., Bärtsch, P., & Oelz, O. (1987). Successful treatment of acute mountain sickness with dexamethasone. British Medical Journal (Clinical Research Ed..), 294(6584), 1380-1382.
- Ferro, J. N. D. S., de Aquino, F. L. T., de Brito, R. G., dos Santos, P. L., Quintans, J. D. S. S., de Souza, L. C., de Araújo, A. F., Diaz, B. L., Lucca‐Júnior, W., Quintans‐Júnior, L. J., & Barreto, E. (2015). Cyclo‐ Gly‐Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice. Clinical and Experimental Pharmacology and Physiology, 42(12), 1287-1295.
- Ghose, A. K., Herbertz, T., Hudkins, R. L., Dorsey, B. D., & Mallamo, J. P. (2012). Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery. ACS Chemical Neuroscience, 3(1), 50-68.
- Ghosh, A., Chakraborty, S., Majumder, S., & Bhattacharya, M. (2022). Comprehensive In silico Investigation Validates Two Flavonoid Compounds of Derris robusta (Roxb. ex DC.) Benth. to Supplant Remdesivir as Natural Therapeutic Remedy Against a Range of Coronaviruses. Letters in Applied NanoBioscience, 12, 4, 108
- Gibson, G. E., & Duffy, T. E. (1981). Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide. Journal of Neurochemistry, 36(1), 28-33.
- Graczyk, M., Przybyszewski, M., Kuźmiński, A., Tlappa, J., Mućka, J., Napiórkowska, K., Szynkiewicz, E., Żbikowska-Gotz, M., & Bartuzi, Z. (2013). Role of E-selectin and platelet endothelial cell adhesion molecule 1 in gastritis in food allergy patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 30(5), 271-276.
- Gupta, M., Lee, H. J., Barden, C. J., & Weaver, D. F. (2019). The blood–brain barrier (BBB) score. Journal of Medicinal Chemistry, 62(21), 9824-9836.
- Hackett, P., Rennie, D., & Levine, H. (1976). The incidence, importance, and prophylaxis of acute mountain sickness. The Lancet, 308(7996), 1149-1155.
- Hitchcock, S. A. (2012). Structural modifications that alter the P-glycoprotein efflux properties of compounds. Journal of Medicinal Chemistry, 55(11), 4877-4895.
- Imray, C., Wright, A., Subudhi, A., & Roach, R. (2010). Acute mountain sickness: pathophysiology, prevention, and treatment. Progress in Cardiovascular Diseases, 52(6), 467-484.
- Jacome-Sosa, M., Vacca, C., Mangat, R., Diane, A., Nelson, R.C., Reaney, M. J., Shen, J., Curtis, J. M., Vine, D. F., Field, C. J., & Igarashi, M. (2016). Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR: LA-cp rat [S]. Journal of Lipid Research, 57(4), 638-649.
- Janoff, E. N., Rubins, J. B., Fasching, C., Charboneau, D., Rahkola, J. T., Plaut, A. G., & Weiser, J. N. (2014). Pneumococcal IgA1 protease subverts specific protection by human IgA1. Mucosal Immunology, 7(2), 249-256.
- Johnson, T. S., Rock, P. B., Fulco, C. S., Trad, L. A., Spark, R. F., & Maher, J. T. (1984). Prevention of acute mountain sickness by dexamethasone. New England Journal of Medicine, 310(11), 683-686.
- Jung, W. C., Jang, Y. J., Kim, J. H., Park, S. S., Park, S. H., Kim, S. J., Mok, Y. J., & Kim, C.S. (2012). Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance. Journal of Gastric Cancer, 12(3), 140-148.
- Juvale, I. I. A., Hamid, A. A. A., Abd Halim, K. B., & Has, A. T. C. (2022). P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease. Heliyon, e09777.
- Kapoor, R., Narula, A. S., & Anand, A. C. (2004). Treatment of acute mountain sickness and high altitude pulmonary oedema. Medical Journal Armed Forces India, 60(4), 384-387.
- Kishimoto, T. (2005). Interleukin-6: from basic science to medicine—40 years in immunology. Annual Review of Immunology, 23, 1-21.
- Laskowski, R. A., & Swindells, M. B. (2011). LigPlot+: multiple ligand–protein interaction diagrams for drug discovery. Journal of Chemical Information and Modeling, 51 (10), 2778-2786
- Li, L., Yu, A. L., Wang, Z. L., Chen, K., Zheng, W., Zhou, J. J., Xie, Q., Yan, H. B., Ren, P., & Huang, X. (2019). Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/-mice via anti-inflammatory and BDNF-TrkB pathway. Biomedicine & Pharmacotherapy, 115, p.108893.
- Li, F., Liu, K., Gray, C., Harris, P., Reynolds, C. M., Vickers, M. H., & Guan, J. (2020). Cyclic glycineproline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutrition, Metabolism and Cardiovascular Diseases, 30(2), 339-346.
- Liang, Z. L., Zhang, X. Y., Wang, F., Zhang, K., Liu, H. F., & Liu, H. L. (2018). Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article). Medicine, 97(39).
- Lipinski, C. A. (2004). Lead-and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies, 1(4), 337-341.
- Liu, X., Zhou, J., Zhang, T., Chen, K., Xu, M., Wu, L., Liu, J., Huang, Y., Nie, B., Shen, X., Ren, P., & Huang, X. (2021). Meranzin hydrate elicits antidepressant effects and restores reward circuitry. Behavioural Brain Research, 398, 112898. https://doi.org/10.1016/j.bbr.2020.112898
- MacLeod-Carey, D., Solis-Céspedes, E., Lamazares, E., & Mena-Ulecia, K. (2020). Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target. Saudi Pharmaceutical Journal, 28(5), 582-592.
- Majumder, S., Ghosh, A., Chakraborty, S., Saha, S., & Bhattacharya, M. (2021). Metabolomics affirms traditional alcoholic beverage raksi as a remedy for high-altitude sickness. Journal of Ethnic Foods, 8(1), 1-10.
- Majumder, S., Chakraborty, S., Ghosh, A., & Bhattacharya, M. (2022). The Himalayan ethnic beverage tongba with therapeutic properties in high-altitude illnesses and metabolomic similarities to Japanese sake. Acta Universitatis Sapientiae, Alimentaria, 15(1), 67-83.
- Majumder, S., Ghosh, A., Saha, S., Acharyya, S., Chakraborty, S., Subba, P., Nandi, S., Sarkar, S., & Bhattacharya, M. (2023). In vitro bioactivities and gastrointestinal simulation validate ethnomedicinal efficacy of five fermented kodo-based Himalayan traditional drinks and bioaccessibility of bioactive components. Food Production, Process and Nutrition (in press)
- Morris, G. M., Goodsell, D. S., Halliday, R. S., Huey, R., Hart, W. E., Belew, R. K., & Olson, A. J. (1998). Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. Journal of Computational Chemistry, 19(14), 1639-1662.
- Mortelmans, K., & Zeiger, E. (2000). The Ames Salmonella/microsome mutagenicity assay. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 455(1-2), 29-60.
- Natesh, R., Schwager, S. L., Sturrock, E. D., & Acharya, K. R. (2003). Crystal structure of the human angiotensin-converting enzyme–lisinopril complex. Nature, 421(6922), 551-554.
- Pajouhesh, H., and George R. Lenz. (2005). Medicinal chemical properties of successful central nervous system drugs. NeuroRx, 2, 541-553.
- Paramashivam, S. K., Elayaperumal, K., bhagavan Natarajan, B., devi Ramamoorthy, M., Balasubramanian, S., & Dhiraviam, K. N. (2015). In silico pharmacokinetic and molecular docking studies of small molecules derived from Indigofera aspalathoides Vahl targeting receptor tyrosine kinases. Bioinformation, 11(2), 73.
- Patel, D.K. (2022). Biological potential and therapeutic effectiveness of meranzin hydrate on intestinal motility. International Journal of Surgery, 100, p.106289.
- Polosa, R., & Blackburn, M. R. (2009). Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease. Trends in Pharmacological Sciences, 30(10), 528-535.
- Potts, R. O., & Guy, R. H. (1992). Predicting skin permeability. Pharmaceutical Research, 9, 663-669.
- Priest, B.T., & McDermott, J.S. (2015). Cardiac ion channels. Channels, 9(6), 352-359.
- Priya, R., Sumitha, R., Doss, C. G. P., Rajasekaran, C., Babu, S., Seenivasan, R., & Siva, R. (2015). Molecular docking and molecular dynamics to identify a novel human immunodeficiency virus inhibitor from alkaloids of Toddalia asiatica. Pharmacognosy Magazine, 11(Suppl 3), S414.
- Riaz, M. B., Khan, A. U., & Qazi, N. G. (2019). Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders. BMC Complementary and Alternative Medicine, 19, 1-22.
- Riley, B. E., Lougheed, J. C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., & Diep, L. (2013). Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nature Communications, 4(1), p.1982.
- Rozwarski, D. A., Vilcheze, C., Sugantino, M., Bittman, R., & Sacchettini, J. C. (1999). Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate. Journal of Biological Chemistry, 274(22), 15582-15589.
- Savioli, G., Ceresa, I. F., Gori, G., Fumoso, F., Gri, N., Floris, V., Varesi, A., Martuscelli, E., Marchisio, S., Longhitano, Y., & Ricevuti, G. (2022). Pathophysiology and therapy of high-altitude sickness: Practical approach in emergency and critical care. Journal of Clinical Medicine, 11(14), p.3937.
- Saxena, P., Hortigon‐Vinagre, M. P., Beyl, S., Baburin, I., Andranovits, S., Iqbal, S. M., Costa, A., IJzerman, A. P., Kügler, P., Timin, E., & Smith, G. L. (2017). Correlation between human ether‐a‐go‐go‐related gene channel inhibition and action potential prolongation. British Journal of Pharmacology, 174(18), 3081-3093.
- Scammell, T. E., Gerashchenko, D. Y., Mochizuki, T., McCarthy, M. T., Estabrooke, I. V., Sears, C. A., Saper, C. B., Urade, Y., & Hayaishi, O. (2001). An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience, 107(4), 653-663.
- Schyman, P., Liu, R., Desai, V., & Wallqvist, A. (2017). vNN web server for ADMET predictions. Frontiers in Pharmacology, 8, p.889.
- Sekiguchi, H., Takabayashi, F., Irie, K., & Murakami, A. (2012). Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice. Journal of Medicinal Food, 15(7), 658-663.
- Semwal, P., Painuli, S., Badoni, H., & Bacheti, R. K. (2018). Screening of phytoconstituents and antibacterial activity of leaves and bark of Quercus leucotrichophora A. Camus from Uttarakhand Himalaya. Clinical Phytoscience, 4, 1-6.
- Sharma, P. K., Suri, T. M., Venigalla, P. M., Garg, S. K., Mohammad, G., Das, P., Sood, S., Saraya, A., & Ahuja, V. (2014). Atrophic gastritis with high prevalence of Helicobacter pylori is a predominant feature in patients with dyspepsia in a high altitude area. Tropical gastroenterology : official journal of the Digestive Diseases Foundation, 35(4), 246–251. https://doi.org/10.7869/tg.224
- Sharma, R., Cramer, N. P., Perry, B., Adahman, Z., Murphy, E. K., Xu, X., Dardzinski, B. J., Galdzicki, Z., Perl, D. P., Dickstein, D. L., & Iacono, D. (2019). Chronic exposure to high altitude: synaptic, astroglial and memory changes. Scientific Reports, 9(1), p.16406.
- Singh, H. B., Prasad, P., & Rai, L.K. (2002). Folk medicinal plants in the Sikkim Himalayas of India. Asian Folklore Studies, 61, 295–310.
- Singh, L. C. G. (2017). High altitude dermatology. Indian Journal of Dermatology, 62(1), 59.
- Smith, C. J., Zhang, Y., Koboldt, C. M., Muhammad, J., Zweifel, B. S., Shaffer, A., Talley, J. J., Masferrer, J. L., Seibert, K., & Isakson, P. C. (1998). Pharmacological analysis of cyclooxygenase-1 in inflammation. Proceedings of the National Academy of Sciences, 95(22), 13313-13318.
- Te Riet, L., van Esch, J. H., Roks, A. J., van den Meiracker, A. H., & Danser, A. J. (2015). Hypertension: renin–angiotensin–aldosterone system alterations. Circulation research, 116(6), 960-975.
- Trott, O., & Olson, A. J. (2010). AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455-461.
- Trzaskowski, B., Latek, D., Yuan, S., Ghoshdastider, U., Debinski, A., & Filipek, S. (2012). Action of molecular switches in GPCRs-theoretical and experimental studies. Current Medicinal Chemistry, 19(8), 1090-1109.
- Willumsen, N. J., Bech, M., Olesen, S. P., Jensen, B. S., Korsgaard, M. P., & Christophersen, P. (2003). High throughput electrophysiology: new perspectives for ion channel drug discovery. Receptors and Channels, 9(1), 3-12.
- Yeerjiang, A., Maimaitiyiming, D., Yang, T., Fang, L., Aihemaitituoheti, A., Aimaiti, M., Zhang, X., & Nijiati, Y. (2023). Pomegranate Peel in the Amelioration of High-Altitude Disease: A Network Pharmacology and Molecular Docking Study of Underlying Mechanisms. Journal of Food Biochemistry, 2023, 7186747.
- Yi, H., Wang, K., Gan, X., Li, L., Zhang, Q., Xiang, J., Yuan, X., Zhang, Y., & Wang, Y. (2020). Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis. Medicine, 99(46).
- Zhao, K., Xing, R., & Yan, X. (2021). Cyclic dipeptides: Biological activities and self‐assembled materials. Peptide Science, 113(2), e24202.