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The Benefits of L-Carnitine in Enhancing Fish Health, Metabolic Regulation, and Stress Reduction: A Review Cover

The Benefits of L-Carnitine in Enhancing Fish Health, Metabolic Regulation, and Stress Reduction: A Review

Open Access
|Aug 2025

References

  1. Agarwal A., Sengupta P., Durairajanayagam D. (2018). Role of L-carnitine in female infertility. Rep. Bio. Endocr., 16: 5.
  2. Ahmad A., Sheikh Abdullah S.R., Hasan H. A., Othman A.R., Ismail N.I. (2021). Aquaculture industry: Supply and demand, best practices, effluent and its current issues and treatment technology. J. Environ. Manage., 287: 112271.
  3. AlatwinusaYohana M., Gyan W.R., Yang Q., Tan B., Lin H., Yi Y., Chi S. (2023). Dietary L-carnitine supplementation for heat stressed juvenile pearl gentian grouper(Epinephelusllanolatus (Epinephelus♂×Epinephelusfuscoguttatus♀): Effects on the antioxidant enzyme, survival, and gene expression. Aquac. Rep., 29: 101524.
  4. Alhasaniah A. H. (2023). L-carnitine: Nutrition, pathology, and health benefits. Saudi J.Biolog. Sci., 30: 103555.
  5. Arense P., Bernal V., Charlier D., Iborra J.L., Foulquié-Moreno M.R., Cánovas M. (2013). Metabolic engineering for high yielding L(-)-carnitine production in Escherichia coli. Microb. Cell Factor., 12: 1–11.
  6. Bernal V., Sevilla Á., Cánovas M., Iborra J.L. (2007). Production of L-carnitine by secondary metabolism of bacteria. Microb. Cell Facto., 6: 1–17.
  7. Chen X., Niu J., Wang J., Zhao W. (2022). Effects of L-carnitine Supplementation in High-Fat Diet on Growth, Antioxidant Capacity and Lipid Metabolism of Golden Pompano (Trachinotus ovatus). Front. Mar. Scien., 9: 1–8.
  8. Chen Y., Sun Z., Liang Z., Xie Y., Su J., Luo Q., Zhu J., Liu Q., Han T., Wang A. (2020). Effects of dietary fish oil replacement by soybean oil and L-carnitine supplementation on growth performance, fatty acid composition, lipid metabolism and liver health of juvenile largemouth bass, Micropterus salmoides. Aqua., 516: 734596.
  9. Ciji A. (2021). Stress management in aquaculture : a review of dietary interventions. 2190–2247. https://doi.org/10.1111/raq.12565
  10. Desai A.S., Singh R. K., Sapkale P.H., Patil S.D. (2010). Effects of feed supplementation with L-carnitine on growth and body composition of Asian catfish, clarias batrachus fry. J. Appl. Ani. Res., 38: 153–157.
  11. El-Sayed M.I., Maximous D.W., Aboziada M.A., Abdel-Wanis M.E., Mikhail N.H. (2010). Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: A Prospective Phase I trial. Ann. Surg. Innovat. Res., 4: 5–11.
  12. Focken U., Becker K., Lawrence P. (1997). A note on the effects of L-carnitine on the energy metabolism of individually reared carp, Cyprinus carpio L. Aqua. Nutrit., 3: 261–264.
  13. Gao Y.S., Chen Y.K., Wang Q.J., Wang, G.Q., Lin L.L., Chen X.M., Wang, Z.R., Zhang D.M. (2021). L-carnitine can improve the population growth and anti-stress ability of rotifer (Brachionus rotundiformis) under ammonia stress. Aqua. Repor., 20: 100622.
  14. Gyan W.R., Yohana M.A., Yang Q., Tan B., Chi S., Yi Y. (2024). The effects of dietary L-carnitine supplementation in fish diet containing high corn gluten meal on immunity, lipid metabolism, and metabolomics in juvenile hybrid grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus). Aquacult. Internat. 32: 833–869
  15. Harpaz S. (1997). Enhancement of growth in juvenile freshwater prawns, Macrobrachium rosenbergii, through the use of a chemoattractant. Aqua., 156: 221–227.
  16. Herrera M., Mancera J.M., Costas B. (2019). The use of dietary additives in fish stress mitigation: Comparative endocrine and physiological responses. Front. Endocrin., 10: 1–22.
  17. Hossain M.S., Koshio S., Kestemont P. (2019). Recent advances of nucleotide nutrition research in aquaculture: a review. Rev. Aqua., 1–26.
  18. Jawahar N., Jubie S. (2019). Stability enhancement and formulation development of l-Carnitine fast-dissolving pellets through pro-drug strateg. J. Dr. Deliv. Scien. Tech., 55: 101474
  19. Li J. M., Li L. Y., Zhang Y.X., Jiang Z.Y., Limbu S.M., Qiao F., Degrace P., Chen L. Q., Zhang M.L., Du Z.Y. (2019). Functional differences between L- and D-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model. Brit. J.Nutr., 122: 625–638.
  20. Li L.Y., Li J. M., Qiao F., Chen L.Q., Zhang M.L., Du Z. Y (2020). Inhibited carnitine synthesis impairs adaptation to high-fat diet in Nile tilapia (Oreochromis niloticus). Aqua. Rep., 16:100249
  21. Li L.Y., Limbu S.M., Ma Q., Chen L. Q., Zhang M.L., Du Z.Y. (2019). The metabolic regulation of dietary L-carnitine in aquaculture nutrition: present status and future research strategies. Rev. Aqua., 11: 1228–1257.
  22. Liu H., Yang J.J., Dong X.H., Tan B.P., Zhang S., Chi S.Y., Yang Q.H., Liu H.Y., Yang Y.Z. (2020). Effects of different dietary carbohydrate-to-lipid ratios on growth, plasma biochemical indexes, digestive, and immune enzymes activities of sub-adult orange-spotted grouper Epinephelus coioides. F. Phy.. Bio., 46: 1409–1420.
  23. Ma J.J., Xu Z.R., Shao Q.J., Xu J.Z., Hung S.S.O., Hu W.L., Zhuo L.Y. (2008). Effect of dietary supplemental L-carnitine on growth performance, body composition and antioxidant status in juvenile black sea bream, Sparus macrocephalus. Aqua. Nutr., 14: 464–471.
  24. Messenger J., Clark S., Massick S., Bechtel M. (2013). A review of Trimethylaminuria: (Fish odor syndrome). J.Clin. Aesth. Dermat., 6: 45–48.
  25. Miyabe Y., Kim N.D., Miyabe C., Luster A.D. (2016). Studying Chemokine Control of Neutrophil Migration in Vivo in a Murine Model of Inflammatory Arthritis. Meth. Enzym. 570:207–231.
  26. Mohseni M., Ozório R.O.A. (2014). Effects of dietary L-carnitine level on growth performance, body composition and antioxidant status in beluga (Huso huso L. 1758). Aqua. Nutr., 20: 477–485.
  27. Niizeki N., Daikoku T., Hirata T., El-Shourbagy I., Song X., Sakaguchi M. (2002). Mechanism of biosynthesis of trimethylamine oxide from choline in the teleost tilapia, Oreochromis niloticus, under freshwater conditions. Comp. Bioch. Phys. - B Bio. Mol. Bio., 131: 371–386.
  28. Obaldo L.G., Divakaran S., Tacon A.G. (2002). Method for determining the physical stability of shrimp feeds in water. Aqua.Res., 33: 369–377.
  29. Ozorio R. (2009). Dietary L-Carnitine Supplementation to Cultivated Fish: A Mini-Review. Cur. Nutr. F. Scien., 5: 40–48.
  30. Ozório R.O.A., Escorcio C., Bessa R.J.B., Ramos B., Gonçalves J.F.M. (2012). Comparative effects of dietary l-carnitine supplementation on diploid and triploid rainbow trout (Oncorhynchus mykiss). Aqua.Nutr. 18: 189–201.
  31. Pradhan C., Soharwardi U., Dileep N., Peter N., Fernandez R., Das S., Kurian A., Elumalai P. (2021). Suitable ratio of dietary L-carnitine and α-ketoglutarate improves growth and health performance in Nile tilapia, Oreochromis niloticus. F. Phy. Bio., 47: 1933–1950.
  32. Ray W., Yohana A., Yang Q. (2024). Corn gluten meal diets supplemented with dietary L-carnitine for juvenile hybrid grouper (♀Epinephelus fuscoguttatus × ♂E. lanceolatus): Impacts on growth performance, immune response and flesh quality. Ani. F. Sci. Tech., 308: 115890.
  33. Roques S., Deborde C., Richard N., Skiba-Cassy S., Moing A., Fauconneau B. (2020). Metabolomics and fish nutrition: a review in the context of sustainable feed development. Revi. in Aqua., 12: 261–282.
  34. Roseiro L.C., Santos C. (2019). Carnitines (Including l-Carnitine, Acetyl-Carnitine, and Proprionyl-Carnitine). Nonvit. Nonmin. Nutr.Supple.. 2019: 45–52.
  35. Rossnerova A., Izzotti A., Pulliero A., Bast A., Rattan S. I. S., Rossner P. (2020). The molecular mechanisms of adaptive response related to environmental stress. Intern. J. Mol. Scien. 21: 1–15.
  36. Soltan M.A., Elfeky A., Fouad I.M. (2016). Effect of L-Carnitine and Amino Acids on Growth and Feed Utilization of Nile Tilapia, Oreochromis niloticus. Glob. Veter., 17: 487–494.
  37. Stone D.A.J., Hardy R.W., Barrows F.T., Cheng Z.J. (2005). Effects of extrusion on nutritional value of diets containing corn gluten meal and corn distiller’s dried grain for rainbow trout, Oncorhynchus mykiss. J. App. Aqua., 17: 1–20.
  38. Van Doan H., Prakash P., Hoseinifar S.H., Ringø E., El-Haroun E., Faggio C., Olsen, R.E., Tran, H.Q., Stejskal, V., Abdel-Latif, H.M.R., Dawood, M.A.O. (2023). Marine-derived products as functional feed additives in aquaculture: A review. Aqua.Rep., 31:101679
  39. Victor H., Lei M., Liu Y., Limbu S.M., Wang Y. (2025). Effect of L-carnitine supplementation on growth performance, feed utilization, body composition, and antioxidant capacity of large yellow croaker, Larimichthys crocea, fed at two dietary lipid levels. Aqua. Intern., 33: 1–18.
  40. Victor H., Liu Y., Limbu S.M., Wang Y. (2024). Dietary L-carnitine and nucleotides synergistically enhance growth performance, feed utilization, and antioxidant capacity of largemouth bass (Micropterus salmoides) juvenile fed a high-fat diet. Aqua.Intern., 32: 4737–4756.
  41. Virmani M.A., Cirulli M. (2022). The Role of L-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation. Intern. J. Mol. Scien. 23: 23052717
  42. Wang Q., Ju, X., Chen Y., Dong X., Luo S., Liu H., Zhang D. (2016). Effects of l-carnitine against H2O2-induced oxidative stress in grass carp ovary cells (Ctenopharyngodon idellus). F. Phy. Bio., 42: 845–857.
  43. Wang S., Guo Z., Wang X., Wang N., Wang J., Zheng N., Zheng R., Fang W., Chen Y., Wang Q., Zhang, D. (2024). Dietary L-carnitine supplementation changes lipid metabolism and glucose utilization of Rhynchocypris lagowskii fed diets with different lipid sources. Fish Phy. Bio., 50: 77–96.
  44. Wang S., Yao Q., Wang N., Zhang D., Wang X., Zheng N., Zhang B., Liu H., Wan J., Chen Y., Wang Q., Guo Z. (2022). Effects of L-carnitine supplementation on growth performance, histomorphology, antioxidant and immune function of Rhynchocypris lagowskii fed dietary fish oil replaced with corn oil. Aqua.Res., 53: 1981–1994.
  45. Yohana M.A., Ray G.W., Yang Q., Beiping T., Shuyan C., Junming D. (2023). Effect of corn gluten meal on the replacement of soybean meal on the survival, biochemical and metabolic responses, and disease resistance of Pacific white shrimp (Litopenaeus vannamei). Ann. Anim. Scien.,. 24:0085
  46. Yohana M.A., Ray G.W., Yang Q., Shiyu K., Tan B., Wu J., Mao M., Ge Z., Feng L. (2024a). Comparative Biochemistry and Physiology - Part D : Genomics and Proteomics Comprehensive analysis of butyric acid impact on immunology , histopathology , gene expression , and metabolomic responses in pacific shrimp experiencing cold stress. Comp.Bio. Phy- D: Gen. Prot., 52: 101293.
  47. Yohana M.A., Ray G.W., Yang Q., Shiyu K., Tan B., Wu J., Mao M., Ge Z., Feng L (2024b). Protective Effects of Butyric Acid during Heat Stress on the Survival, Immune Response, Histopathology, and Gene Expression in the Hepatopancreas of Juvenile Pacific Shrimp (L. vannamei). F. Shellf. Immun., 150: 109610.
  48. Yu T., Wang Q.J, Chen X.M, Chen Y.K, Ghonimy A., Zhang D.M, Wang G.Q. (2020). Effect of dietary L-carnitine supplementation on growth performance and lipid metabolism in Rhynchocypris lagowski Dybowski fed oxidized fish oil. Aqu.Res., 51: 3698–3710.
  49. Yu Z.L., Zhang L.Y., Jiang X.M., Xue C.H., Chi N., Zhang T.T., Wang Y. M. (2020). Effects of dietary choline, betaine, and L-carnitine on the generation of trimethylamine-N-oxide in healthy mice. J. F. Scien., 85: 2207–2215.
  50. Zheng J.L., Luo Z., Zhuo M.Q., Pan Y.X., Song,Y.F., Hu W., Chen Q.L. (2014). Dietary L -carnitine supplementation increases lipid deposition in the liver and muscle of yellow catfish ( Pelteobagrus fulvidraco ) through changes in lipid metabolism. Brit. Nut., 112: 698–708.
DOI: https://doi.org/10.2478/aoas-2025-0062 | Journal eISSN: 2300-8733 | Journal ISSN: 1642-3402
Language: English
Submitted on: Oct 31, 2024
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Accepted on: May 22, 2025
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Published on: Aug 20, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2025 Alatwinusa Yohana Mpwaga, Ray Watson Gyan, Lishuko Ng’onga, Runmin Guo, Qihui Yang, published by National Research Institute of Animal Production
This work is licensed under the Creative Commons Attribution 4.0 License.

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