Table 1:
Population characteristics of included trials
| Study | Country | Study Type (RCTs) | Participants | Age (Years) | Diagnosis |
|---|---|---|---|---|---|
| Alshimy, Ahmed Mag dy, et al., (Nct, 2022) | Egypt | RCT | N = 42 NMG = 21 STPG = 21 | NMG = 52.72 ± 4 STPG = 51.14 ± 4.92 | Diabetic Neuropathy |
| (Sharma & Kalia, 2023) | India | RCT | N = 40 Group 1 = 20 Group 2 = 20 Male = 18 Female = 22 | Group 1 = 56.65 ± 4.57 Group 2 = 56.8 ± 3.87 | Diabetic Neuropathy |
| (Kumar et al., 2011) | India | RCT | N = 32 CG = 16 EG = 16 | CG = 57.43 ± 12.04 EG = 62.81 ± 10.43 | Diabetic Neuropathy |
| (Chacón et al., 2024) | Mexico | RCT | N = 34 Older adults = 17 Adults = 17 | Older adults = 76.5 Adults = 23.5 | Diabetic Neuropathy |
Table 2:
Details of interventions of included trials
| Study | Control Group Intervention | Experimental Group Intervention | Dosage | ||
|---|---|---|---|---|---|
| Session | Duration | Total Weeks | |||
| (Nct, 2022) | STGP graduated active range of motion exercises for both UL and LL joints and gait training | NMG on median nerve and tibial nerve | 3 session per week | 30 minutes | 4 weeks |
| (Sharma & Kalia, 2023) | Balance gait training | Neural mobilization with balance gait training | Once a day for 5 days a week | 35 minutes | 4 weeks |
| (Kumar et al., 2011) | Drugs for glycemic control, analgesics, lifestyle modifications and walk | In addition, tibial nerve neurodynamic mobilization | One session per week | 45 minutes | 5 weeks |
| (Chacón et al., 2024) | Radial neurodynamics, ulnar neurodynamics and median neurodynamics | Sciatic neurodynamics and Peroneus neurodynamics | Once a day per week | 25 minutes | 8 weeks |
Table 3:
Outcome measures, findings, and results of included studies
| Study | Outcome measures | Follow UP | Results | Conclusion | ||
|---|---|---|---|---|---|---|
| Experimental Group Differences (Mean±SD) | Findings | |||||
| Experimental Group | Control Group | |||||
| (Nct, 2022) | (Sensory and motor nerve conduction velocity) (Visual analogue scale) (Katz index) | 4 weeks | VAS = 7 ± 1.14 MSN-NcV = 39.12 ± 5.61 TMN-NcV = 37.42 ± 2.49 Katz index = 3 ± 1.14 | VAS = 7 ± 1.14 MSN-NcV = 39.95 ± 5.89 TMN-NcV = 38.48 ± 2.54 Katz index = 3 ± 1.14 | VAS P = 0.001 MSN-NcV P = 0.002 TMN-NcV p = 0.001 Katz index P = 0.001 | No significant difference |
| (Sharma & Kalia, 2023) | BBS DGI TUG VPT | 4 weeks | BBS = 40.5 ± 5.73 DGI = 13.60 ± 3.25 TUG = 19.50 ± 4.11 VPT = 17.77 ± 2.48 | BBS = 47.5 ± 5.73 DGI = 18.5 ± 3.69 TUG = 15.85 ± 3.65 VPT = 16.74 ± 2.60 | EG BBS P = 0.0001 DGI P = 0.0001 TUG P = 0.0001 VPT P = 0.0001 CG BBS P = 0.63 DGI P = 0.52 TUG P = 0.69 VPT P = 0.001 | NM with BGT showed significant impact on BBS, DGI and TUG. BGT alone showed non-significant difference. |
| (Kumar et al., 2011) | NPQ (pre- post) NeuroQoL (pre-post) Vibration Thresholds (pre- post) volts SLR2 ROM (pre-post) degrees | 5 weeks | NPQ (pre- post) = 28.5 ± 7.15 NeuroQoL (pre- post) = 28.63 ± 6.84 Vibration Thresholds (pre- post) = 16.5 ± 3.14 volts SLR2 ROM (pre- post) degrees = −8.62 ± 5.79 | NPQ (pre- post) = 9.61 ± 4.69 NeuroQoL (pre- post) = 12.7 ± 3.99 Vibration Thresholds (pre-post) = 10.56 ± 2.22 volts SLR2 ROM (pre-post) degrees = −4.62 ± 2.94 | NPQ (pre- post) P = .000 NeuroQoL (pre- post) P = .000 Vibration Thresholds (pre- post) P = .000 volts SLR2 ROM (pre-post) degrees P = .020 | Both the groups showed statistically significant improvements in all the four variables studied |
| (Chacón et al., 2024) | Michigan Questionnaire Sensitivity test | 8 weeks | MNSI = 76.5% TSSM = (2,0,0) ThSSM = (1.88235,0.0,0.11765) TSLM = (1.76471,0.00,0.23529) ThSLM = (1.52941,0.00,0.47059) VSM = (0.588,0.294,0.118) VLM = (0.706,0.176,0.118) | MNSI = 100% TSSM = (2,0,0) ThSSM = (2,0,0) TSLM = (2,0,0) ThSLM = (2,0,0) VSM = (1,0,0) VLM = (0.882,0.118,0) | MNSI P = (4.6610×10−29,4.4833×10−25,1.8120× 10−45) TSSM P = (□□, □□,□□) ThSSM P = (5.8069×10−12, □□, 1.5987×10−14) TSLM P = (2.6017×10−22,□□, 0.00) ThSLM P = (7.3437×10−31, □□,0.00) VSM P = (1.9620×10−30,0.00,6.7526×10−12) VLM P = (2.2287×10−30,2.5083×10−7,2.1578× 10−12) | This study showed significant results of neurodynamic mobilization techniques. |
[i] Pubmed : ((((diabetic neuropathy[MeSH Terms]) OR (diabetic neuropathy)) OR (diabetic neuropathy[Text Word])) AND (((mobilization) OR (neurodynamic)) OR (neurodynamics[Text Word]))) AND (((rehabilitation[MeSH Terms]) OR (rehabilitation[Text Word])) OR (rehabilitation))
[ii] Pedro : ((((diabetic neuropathy[MeSH Terms]) OR (diabetic neuropathy)) OR (diabetic neuropathy[Text Word])) AND (((mobilization) OR (neurodynamic)) OR (neurodynamics[Text Word]))) AND (((rehabilitation[MeSH Terms]) OR (rehabilitation[Text Word])) OR (rehabilitation))
