Effectiveness of Neural Mobilizations Techniques on Diabetic Peripheral Neuropathies: A Systematic Review

Study	Control Group Intervention	Experimental Group Intervention	Dosage
Study	Control Group Intervention	Experimental Group Intervention	Session	Duration	Total Weeks
(Nct, 2022)	STGP graduated active range of motion exercises for both UL and LL joints and gait training	NMG on median nerve and tibial nerve	3 session per week	30 minutes	4 weeks
(Sharma & Kalia, 2023)	Balance gait training	Neural mobilization with balance gait training	Once a day for 5 days a week	35 minutes	4 weeks
(Kumar et al., 2011)	Drugs for glycemic control, analgesics, lifestyle modifications and walk	In addition, tibial nerve neurodynamic mobilization	One session per week	45 minutes	5 weeks
(Chacón et al., 2024)	Radial neurodynamics, ulnar neurodynamics and median neurodynamics	Sciatic neurodynamics and Peroneus neurodynamics	Once a day per week	25 minutes	8 weeks

Population characteristics of included trials

Study	Country	Study Type (RCTs)	Participants	Age (Years)	Diagnosis
Alshimy, Ahmed Mag dy, et al., (Nct, 2022)	Egypt	RCT	N = 42 NMG = 21 STPG = 21	NMG = 52.72 ± 4 STPG = 51.14 ± 4.92	Diabetic Neuropathy
(Sharma & Kalia, 2023)	India	RCT	N = 40 Group 1 = 20 Group 2 = 20 Male = 18 Female = 22	Group 1 = 56.65 ± 4.57 Group 2 = 56.8 ± 3.87	Diabetic Neuropathy
(Kumar et al., 2011)	India	RCT	N = 32 CG = 16 EG = 16	CG = 57.43 ± 12.04 EG = 62.81 ± 10.43	Diabetic Neuropathy
(Chacón et al., 2024)	Mexico	RCT	N = 34 Older adults = 17 Adults = 17	Older adults = 76.5 Adults = 23.5	Diabetic Neuropathy

Outcome measures, findings, and results of included studies

Study	Outcome measures	Follow UP	Results			Conclusion
			Experimental Group Differences (Mean±SD)		Findings
			Experimental Group	Control Group	Findings
(Nct, 2022)	(Sensory and motor nerve conduction velocity) (Visual analogue scale) (Katz index)	4 weeks	VAS = 7 ± 1.14 MSN-NcV = 39.12 ± 5.61 TMN-NcV = 37.42 ± 2.49 Katz index = 3 ± 1.14	VAS = 7 ± 1.14 MSN-NcV = 39.95 ± 5.89 TMN-NcV = 38.48 ± 2.54 Katz index = 3 ± 1.14	VAS P = 0.001 MSN-NcV P = 0.002 TMN-NcV p = 0.001 Katz index P = 0.001	No significant difference
(Sharma & Kalia, 2023)	BBS DGI TUG VPT	4 weeks	BBS = 40.5 ± 5.73 DGI = 13.60 ± 3.25 TUG = 19.50 ± 4.11 VPT = 17.77 ± 2.48	BBS = 47.5 ± 5.73 DGI = 18.5 ± 3.69 TUG = 15.85 ± 3.65 VPT = 16.74 ± 2.60	EG BBS P = 0.0001 DGI P = 0.0001 TUG P = 0.0001 VPT P = 0.0001 CG BBS P = 0.63 DGI P = 0.52 TUG P = 0.69 VPT P = 0.001	NM with BGT showed significant impact on BBS, DGI and TUG. BGT alone showed non-significant difference.
(Kumar et al., 2011)	NPQ (pre- post) NeuroQoL (pre-post) Vibration Thresholds (pre- post) volts SLR2 ROM (pre-post) degrees	5 weeks	NPQ (pre- post) = 28.5 ± 7.15 NeuroQoL (pre- post) = 28.63 ± 6.84 Vibration Thresholds (pre- post) = 16.5 ± 3.14 volts SLR2 ROM (pre- post) degrees = −8.62 ± 5.79	NPQ (pre- post) = 9.61 ± 4.69 NeuroQoL (pre- post) = 12.7 ± 3.99 Vibration Thresholds (pre-post) = 10.56 ± 2.22 volts SLR2 ROM (pre-post) degrees = −4.62 ± 2.94	NPQ (pre- post) P = .000 NeuroQoL (pre- post) P = .000 Vibration Thresholds (pre- post) P = .000 volts SLR2 ROM (pre-post) degrees P = .020	Both the groups showed statistically significant improvements in all the four variables studied
(Chacón et al., 2024)	Michigan Questionnaire Sensitivity test	8 weeks	MNSI = 76.5% TSSM = (2,0,0) ThSSM = (1.88235,0.0,0.11765) TSLM = (1.76471,0.00,0.23529) ThSLM = (1.52941,0.00,0.47059) VSM = (0.588,0.294,0.118) VLM = (0.706,0.176,0.118)	MNSI = 100% TSSM = (2,0,0) ThSSM = (2,0,0) TSLM = (2,0,0) ThSLM = (2,0,0) VSM = (1,0,0) VLM = (0.882,0.118,0)	MNSI P = (4.6610×10−29,4.4833×10−25,1.8120× 10−45) TSSM P = (□□, □□,□□) ThSSM P = (5.8069×10−12, □□, 1.5987×10−14) TSLM P = (2.6017×10−22,□□, 0.00) ThSLM P = (7.3437×10−31, □□,0.00) VSM P = (1.9620×10−30,0.00,6.7526×10−12) VLM P = (2.2287×10−30,2.5083×10−7,2.1578× 10−12)	This study showed significant results of neurodynamic mobilization techniques.

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DOI: https://doi.org/10.2478/ajon-2026-0004 | Journal eISSN: 2208-6781 | Journal ISSN: 1032-335X

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Language: English

Page range: 22 - 34

Published on: May 18, 2026

Published by: Australasian Neuroscience Nurses Association

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Neural Mobilization Techniques,

Neurodynamics,

Diabetic Peripheral Neuropathy,

Functional ability,

Motor rehabilitation

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2026 Asad Anwar, Marium Zafar, Aqsa Saman, published by Australasian Neuroscience Nurses Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 36 (2026): Issue 1 (May 2026)