Mechanism of RBM15 in Regulating PD-L1-Mediated Immune Escape in Ovarian Cancer Through the JAK2/STAT3/STAT5 Pathway

Chengju Zhang; Tiantian Feng; Hu Wang; Deng He; Xi Wang; Shangqi Ni; Yuesong Wang

doi:10.2478/aite-2026-0009

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Mechanism of RBM15 in Regulating PD-L1-Mediated Immune Escape in Ovarian Cancer Through the JAK2/STAT3/STAT5 Pathway

Archivum Immunologiae et Therapiae Experimentalis

Volume 74 (2026): Issue 1 (January 2026)

By: Chengju Zhang, Tiantian Feng, Hu Wang, Deng He, Xi Wang, Shangqi Ni and Yuesong Wang

Open Access

|Feb 2026

Abstract

This paper elucidates the role of RNA-binding motif protein 15 (RBM15) in programmed death-ligand 1 (PD-L1)-mediated immune escape in ovarian cancer (OC), providing a novel immunotherapeutic strategy. RBM15/circFGFR3/JAK2/STAT3/STAT5 expression was assessed. OC cell progression was analyzed. OC cells were co-cultured with CD8⁺ T cells. The m6A enrichment on circRNA fibroblast growth factor receptor 3 (circFGFR3) was determined. The expression of p-JAK2, p-STAT3, and p-STAT5 was investigated. The bindings of circFGFR3 to EIF4A3 and EIF4A3 to JAK2, STAT3, or STAT5 were analyzed. In conclusion, RBM15 promotes PD-L1-mediated immune escape and accelerates OC progression by upregulating circFGFR3 expression through m6A modification and activating the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway.

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Articles in this issue

DOI: https://doi.org/10.2478/aite-2026-0009 | Journal eISSN: 1661-4917

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Language: English

Submitted on: Jul 15, 2025

Accepted on: Nov 28, 2025

Published on: Feb 11, 2026

Published by: Hirszfeld Institute of Immunology and Experimental Therapy

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

Ovarian cancer,

RBM15,

Immune escape

Related subjects:

Medicine,

Basic medical science,

Biochemistry,

Immunology,

Clinical medicine,

Clinical medicine, other,

Clinical chemistry

© 2026 Chengju Zhang, Tiantian Feng, Hu Wang, Deng He, Xi Wang, Shangqi Ni, Yuesong Wang, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 74 (2026): Issue 1 (January 2026)