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Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells Cover

Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells

Open Access
|Dec 2025

Authors

Sheng-Yuan Chen

Department of Marine Biotechnology and Research, National Sun Yat-sen University, Kaohsiung, Taiwan
Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan

En-De Shu

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

Jiann-Jyh Huang

Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan

Yen-Chun Chen

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

Sheng-Kai Hsu

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

Wen-Tsan Chang

Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Transplantation Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

I-Ling Lin

Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

Chia-Hung Kuo

Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan

Ming-Fong Tsai

Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan

Zhi-Hong Wen

wzh@mail.nsysu.edu.tw

Department of Marine Biotechnology and Research, National Sun Yat-sen University, Kaohsiung, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung, Taiwan

Chien-Chih Chiu

cchiu@kmu.edu.tw

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Language: English
Submitted on: Jun 20, 2025
Accepted on: Nov 6, 2025
Published on: Dec 20, 2025
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Sheng-Yuan Chen, En-De Shu, Jiann-Jyh Huang, Yen-Chun Chen, Sheng-Kai Hsu, Wen-Tsan Chang, I-Ling Lin, Chia-Hung Kuo, Ming-Fong Tsai, Zhi-Hong Wen, Chien-Chih Chiu, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.