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Antioxidant and Antibacterial Properties of Leaf and Root Extracts of Dipsacus fullonum Cover

Antioxidant and Antibacterial Properties of Leaf and Root Extracts of Dipsacus fullonum

Open Access
|Aug 2025

Figures & Tables

Figure 1.

Comparison of the content of groups of secondary metabolites: hydroxycinnamic derivatives (THD), total polyphenols (TP), and tannins, calculated per weight of dried extract of leaves and roots of D. fullonum. The bars represent mean ± SD, n=4; *** = p <0.001 extracts of leaves vs. extracts of roots (ANOV A/Bonferroni).
Comparison of the content of groups of secondary metabolites: hydroxycinnamic derivatives (THD), total polyphenols (TP), and tannins, calculated per weight of dried extract of leaves and roots of D. fullonum. The bars represent mean ± SD, n=4; *** = p <0.001 extracts of leaves vs. extracts of roots (ANOV A/Bonferroni).

Figure 2.

Dose-dependent inhibition of DPPH radical by D. fullonum extracts of leaves, roots a 1:lmixture of leaves and roots extracts, and chlorogenic acid as the positive control. The bars represent the mean ± SD, n=4. Pearson’s two-tailed correlation test was used to assess the correlation, where p<0.05 was observed for the leaves and chlorogenic acid, and p<0.01 for the roots and 1:1 mixture.
Dose-dependent inhibition of DPPH radical by D. fullonum extracts of leaves, roots a 1:lmixture of leaves and roots extracts, and chlorogenic acid as the positive control. The bars represent the mean ± SD, n=4. Pearson’s two-tailed correlation test was used to assess the correlation, where p<0.05 was observed for the leaves and chlorogenic acid, and p<0.01 for the roots and 1:1 mixture.

MIC and MBC of extracts of leaves and roots of D_ fullonum on reference bacterial strains_

BacteriaLeavesRootsStreptomycin
MIC [mg/mL]MIC [mg/mL]MIC [mg/mL]MBC [mg/mL]MIC [mg/mL]MBC [mg/mL]
MSSA10>40>40>400.0020.002
MRSA20>40>40>400.0020.004
P. aeruginosa40>40>40>400.0040.008
E. coli>40>40>40>400.0040.008
E. faecalis>40>40>40>400.0150.060
P. mirabilis40>40>40>400.0080.008

Overview of IC50, correlation coefficient (r) and CI values for D_ fullonum leaves extract, roots extract, their mixture in the ratio of 1:1 and chlorogenic acid_

Extract/combinationIC50 [μg/mL]rCI
Leaves34.780.9816-
Roots53.810.9945-
1:1 mixture42.670.99701.01
Chlorogenic acid3.560.9879-
Language: English
Page range: 41 - 46
Submitted on: Mar 17, 2025
Accepted on: Jun 17, 2025
Published on: Aug 16, 2025
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
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© 2025 Kamila Dokupilová, E. Kostovčíková, E. Kurin, P. Mučaji, Fialová S. Bittner, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.