The Pathobiology of Myocardial Recovery and Remission: From Animal Models to Clinical Observations in Heart Failure Patients

Arick C. Park; Douglas L. Mann

doi:10.14797/mdcvj.1389

The Pathobiology of Myocardial Recovery and Remission: From Animal Models to Clinical Observations in Heart Failure Patients

Methodist DeBakey Cardiovascular Journal

Volume 20 (2024): Issue 4

By: Arick C. Park and Douglas L. Mann

Open Access

|Aug 2024

Abstract

Heart failure with reduced left ventricular (LV) ejection fraction (HFrEF) is a morbid and life-threatening disease, arising secondary to abnormalities of cardiac structure and function that lead to adverse LV remodeling. Implementation of medical and device therapies results in significant improvements in patient outcomes that are associated with reverse LV remodeling and improved LV ejection fraction. This review provides an overview of the pathobiology of reverse LV remodeling in animal models and in HFrEF patients. We emphasize the differences between myocardial recovery and remission as well as the fragile nature of maintaining a state of myocardial remission.

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Articles in this issue

DOI: https://doi.org/10.14797/mdcvj.1389 | Journal eISSN: 1947-6108

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Language: English

Page range: 16 - 30

Submitted on: Apr 8, 2024

Accepted on: Jun 21, 2024

Published on: Aug 20, 2024

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

heart failure,

LV remodeling,

reverse LV remodeling,

myocardial remission,

myocardial recovery

© 2024 Arick C. Park, Douglas L. Mann, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 20 (2024): Issue 4