| SIRT1 (10q21.3) | jądro komórkowe, cytoplazma | H: H4K16, H3K9, H1K26, | około 82 kDa [35, 91]
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| NH: FoxO, Ku70, p53, SREBP, TAFI68, PGAM1, UCP2, NF-κB, PGC1α, PPARγ |
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| SIRT2 (19q13.1) | jądro komórkowe, cytoplazma | H: H4K16, H3K6, H4K8 | 42 kDa [35]
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| NH: FoxO3a, FoxO1, α-tubulina, PEPCK1 |
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| SIRT3 (11p15.5) | mitochondrium | H: H3K9, H4K16 | forma dłuższa : 44 kDa [35] forma krótsza: 28 kDa [86]
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| NH: FoxO3a, Ku70, GDH, SDH, OGG1 |
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| SIRT4 (12q) | mitochondrium | H: H3K9, H3K56 | 44 kDa [35]
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| NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 |
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| SIRT5 (6p25) | mitochondrium, cytoplazma, jądro komórkowe | NH: SDH, GLS, CPS1, PDC, UOX, HMGCS2 | 34 kDa [35, 91]
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| SIRT6 (19p13.3) | jądro komórkowe | H: H3K9, H3K56 | 39 kDa [35]
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| NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 |
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| SIRT7 (17q25) | jądro komórkowe | H: H3K18, H3K122 | 48 kDa [35]
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| NH: HIF1α, HIF2α, Myc, GABPβ1, PAF53, kompleks ligazy ubikwitynowej, polimeraza III |
![Umiejscowienie sirtuin w komórce; SIRT1-SIRT7: sirtuiny 1–7; wg [15, 40], zmodyfikowano](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7866_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251007%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251007T150134Z&X-Amz-Expires=3600&X-Amz-Signature=6261393303387d51e560261215fb95a3b39470081decfb51b4806f21fcb05a2b&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)