Regulation of Tumor Metabolome by Long Non-Coding RNAs

Revathy Nadhan; Danny N. Dhanasekaran

doi:10.55233/1750-2187-16-1

Regulation of Tumor Metabolome by Long Non-Coding RNAs

Journal of Molecular Signaling

Volume 16 (2022): Issue 1

By: Revathy Nadhan and Danny N. Dhanasekaran

Open Access

|Nov 2022

Abstract

Tumorigenesis necessitates enhanced ability for macromolecular biosynthesis, higher energy/ATP levels and co-ordinated redox balance systems within the cancer cells as well as the cellular components of the tumor microenvironment. Cancer cells have adapted several mechanisms to accommodate their growing need for energy and macromolecular building blocks. A critical mechanism that sustains cancer growth and progression is metabolic reprogramming. Metabolic reprogramming refers to the process that changes the pattern of metabolism in these cells that regulates cancer energetics and metabolic biosynthesis. Recent studies have shown a role for long non-coding RNAs (lncRNAs) in the metabolic reprogramming of multiple cell types in cancer tissue. LncRNAs play a decisive role in the reprogramming of glucose, lipid, amino acid, and nucleotide metabolisms to promote tumor growth. Emerging tumorigenic role of lncRNAs and the diverse mechanisms through which they reprogram tumor metabolome is comprehensively discussed here.

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Articles in this issue

DOI: https://doi.org/10.55233/1750-2187-16-1 | Journal eISSN: 1750-2187

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Language: English

Page range: 1 - 1

Submitted on: Nov 3, 2022

Accepted on: Nov 3, 2022

Published on: Nov 23, 2022

Published by: Danny N. Dhanasekaran

In partnership with: Paradigm Publishing Services

Keywords:

cancer,

IncRNA,

tumor metabolome,

metabolomics,

targeted therapy

© 2022 Revathy Nadhan, Danny N. Dhanasekaran, published by Danny N. Dhanasekaran
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 16 (2022): Issue 1