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Burden and Trends of Aortic Aneurysms in Individuals Aged 55 and Older from 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021 Cover

Burden and Trends of Aortic Aneurysms in Individuals Aged 55 and Older from 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021

Open Access
|Jan 2026

References

  1. Quintana RA, Taylor WR. Introduction to the compendium on aortic aneurysms. Circulation Research. 2019;124:470471. DOI: 10.1161/CIRCRESAHA.119.314765
  2. Bossone E, Eagle KA. Epidemiology and management of aortic disease: Aortic aneurysms and acute aortic syndromes. Nature Reviews Cardiology. 2021;18:331348. DOI: 10.1038/s41569-020-00472-6
  3. Gao J, Cao H, Hu G, Wu Y, Xu Y, Cui H, et al. The mechanism and therapy of aortic aneurysms. Signal Transduction and Target Therapy. 2023;8:55. DOI: 10.1038/s41392-023-01325-7
  4. Gupta AK, Alshaikh HN, Dakour-Aridi H, King RW, Brothers TE, Malas MB. Real-world cost analysis of endovascular repair versus open repair in patients with nonruptured abdominal aortic aneurysms. Journal of Vascular Surgery. 2020;71:432443.e4. DOI: 10.1016/j.jvs.2018.12.059
  5. Cho MJ, Lee MR, Park JG. Aortic aneurysms: current pathogenesis and therapeutic targets. Experimental & Molecular Medicine. 2023;55:25192530. DOI: 10.1038/s12276-023-01130-w
  6. Liu B, Granville DJ, Golledge J, Kassiri Z. Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm. American Journal of Physiology-Heart and Circulatory Physiology. 2020;318:H652H670. DOI: 10.1152/ajpheart.00621.2019
  7. Conrad N, Molenberghs G, Verbeke G, Zaccardi F, Lawson C, Friday JM, et al. Trends in cardiovascular disease incidence among 22 million people in the UK over 20 years: Population based study. BMJ. 2024;385:e078523. DOI: 10.1136/bmj-2023-078523
  8. GBD 2021 US Burden of Disease Collaborators. The burden of diseases, injuries, and risk factors by state in the USA, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;404:23142340. DOI: 10.1016/S0140-6736(24)01446-6
  9. Zeller JL, Burke AE, Glass RM. Aortic aneurysms. JAMA. 2009;302:2050. DOI: 10.1001/jama.302.18.2050
  10. Naghavi M, Ong KL, Aali A, Ababneh HS, Abate YH, Abbafati C, et al. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:21002132. DOI: 10.1016/S0140-6736(24)00367-2
  11. Ferrari AJ, Santomauro DF, Aali A, Abate YH, Abbafati C, Abbastabar H, et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:21332161. DOI: 10.1016/S0140-6736(24)00757-8
  12. Arndt MB, Abate YH, Abbasi-Kangevari M, Abd ElHafeez S, Abdelmasseh M, Abd-Elsalam S, et al. Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2025;404:25432583. DOI: 10.1016/S0140-6736(24)01821-X
  13. Ilic M, Ilic I. Cancer mortality in Serbia, 1991–2015: An age-period-cohort and joinpoint regression analysis. Cancer Communications. 2018;38:10. DOI: 10.1186/s40880-018-0282-3
  14. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Statistics in Medicine. 2000;19:335351. DOI: 10.1002/(SICI)1097-0258(20000215)19:3<;335::AID-SIM336>3.0.CO;2-Z
  15. Das Gupta P. Standardization and decomposition of rates from cross-classified data. Genus. 1994;50:171196.
  16. Cheng X, Yang Y, Schwebel DC, Liu Z, Li L, Cheng P, et al. Population ageing and mortality during 1990–2017: A global decomposition analysis. PLoS Medicine. 2020;17:e1003138. DOI: 10.1371/journal.pmed.1003138
  17. Zhang J, Pan L, Guo Q, Lai Y, Liu T, Wang H, et al. The impact of global, regional, and national population ageing on disability-adjusted life years and deaths associated with diabetes during 1990–2019: A global decomposition analysis. Diabetes & Metabolic Syndrome. 2023;17:102791. DOI: 10.1016/j.dsx.2023.102791
  18. World Health Organization. Handbook on health inequality monitoring: With a special focus on low-and middle-income countries. World Health Organization; 2013.
  19. Jin Y, Guo C, Abbasian M, Abbasifard M, Abbott JH, Abdullahi A, et al. Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050. Med. 2024;5:943962.e6. DOI: 10.1016/j.medj.2024.04.009
  20. Xie Y, Bowe B, Mokdad AH, Xian H, Yan Y, Li T, et al. Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney International. 2018;94:567581. DOI: 10.1016/j.kint.2018.04.011
  21. Knoll M, Furkel J, Debus J, Abdollahi A, Karch A, Stock C. An R package for an integrated evaluation of statistical approaches to cancer incidence projection. BMC Medical Research Methodology. 2020;20:257. DOI: 10.1186/s12874-020-01133-5
  22. Bai Z, Han J, An J, Wang H, Du X, Yang Z, et al. The global, regional, and national patterns of change in the burden of congenital birth defects, 1990–2021: An analysis of the global burden of disease study 2021 and forecast to 2040. EClinicalMedicine. 2024;77:102873. DOI: 10.1016/j.eclinm.2024.102873
  23. Summers KL, Kerut EK, Sheahan CM, Sheahan MG, 3rd. Evaluating the prevalence of abdominal aortic aneurysms in the United States through a national screening database. Journal of Vascular Surgery. 2021;73:6168. DOI: 10.1016/j.jvs.2020.03.046
  24. US Preventive Services Task Force. Screening for abdominal aortic aneurysm: Recommendation statement. Annals of Internal Medicine. 2005;142:198202. DOI: 10.7326/0003-4819-142-3-200502010-00011
  25. LeFevre ML. Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommendation statement. Annals of Internal Medicine. 2014;161:281290. DOI: 10.7326/M14-1204
  26. Wanhainen A, Björck M. The Swedish experience of screening for abdominal aortic aneurysm. Journal of Vascular Surgery. 2011;53:11641165. DOI: 10.1016/j.jvs.2010.10.099
  27. Davis M, Harris M, Earnshaw JJ. Implementation of the national health service abdominal aortic aneurysm screening program in England. Journal of Vascular Surgery. 2013;57:14401445. DOI: 10.1016/j.jvs.2012.10.114
  28. Spronk S, van Kempen BJ, Boll AP, Jørgensen JJ, Hunink MG, Kristiansen IS. Cost-effectiveness of screening for abdominal aortic aneurysm in the Netherlands and Norway. British Journal of Surgery. 2011;98:15461555. DOI: 10.1002/bjs.7620
  29. Olchanski N, Winn A, Cohen JT, Neumann PJ. Abdominal aortic aneurysm screening: how many life years lost from underuse of the medicare screening benefit? Journal of General Internal Medicine. 2014;29:11551161. DOI: 10.1007/s11606-014-2831-z
  30. Zong NC, Huang K, Yang X, Cai H. Expand the success of routine screening to reduce aortic aneurysm mortality: Progress interpretation and new fronts. Trends in Cardiovascular Medicine. 2024;35(4):221229. DOI: 10.1016/j.tcm.2024.12.004
  31. Golledge J, Thanigaimani S, Powell JT, Tsao PS. Pathogenesis and management of abdominal aortic aneurysm. European Heart Journal. 2023;44:26822697. DOI: 10.1093/eurheartj/ehad386
  32. Dai X, Gakidou E, Lopez AD. Evolution of the global smoking epidemic over the past half century: strengthening the evidence base for policy action. Tobacco Control. 2022;31:129137. DOI: 10.1136/tobaccocontrol-2021-056535
  33. Krafcik BM, Stone DH, Cai M, Jarmel IA, Eid M, Goodney PP, et al. Changes in global mortality from aortic aneurysm. Journal of Vascular Surgery. 2024;80:8188.e1. DOI: 10.1016/j.jvs.2024.02.025
  34. Bedwell GJ, Dias P, Hahnle L, Anaeli A, Baker T, Beane A, et al. Barriers to quality perioperative care delivery in low- and middle-income countries: A qualitative rapid appraisal study. Anesthesia & Analgesia. 2022;135:12171232. DOI: 10.1213/ANE.0000000000006113
  35. Nargesi S, Abutorabi A, Alipour V, Tajdini M, Salimi J. Cost-effectiveness of endovascular versus open repair of abdominal aortic aneurysm: A systematic review. Cardiovascular Drugs and Therapy. 2021;35:829839. DOI: 10.1007/s10557-020-07130-6
  36. Bencheikh N, Zarrintan S, Quatramoni JG, Al-Nouri O, Malas M, Gaffey AC. Vascular surgery in low-income and middle-income countries: A state-of-the-art review. Annals of Vascular Surgery. 2023;95:297306. DOI: 10.1016/j.avsg.2023.05.024
  37. Mouyarden O, Bakkali T, Azghari A. Vascular surgery in morocco: Challenges and perspectives. European Journal of Vascular and Endovascular Surgery. 2022;64:13. DOI: 10.1016/j.ejvs.2022.05.031
  38. Cassimjee I, le Roux D, Pillai J, Veller M. Vascular surgery in South Africa in 2021. European Journal of Vascular and Endovascular Surgery. 2021;61:719720. DOI: 10.1016/j.ejvs.2021.03.001
  39. Lundgren F, Hodza-Beganovic R, Johansson M, Seyoum N, Tadesse M, Andersson P. A vascular surgery exchange program between Ethiopia and Sweden: A plus for both. IJS Global Health. 2020;3:e43. DOI: 10.1097/GH9.0000000000000043
  40. Hassani M, Nozarinia M, Marashi SA. COVID-19 disease, its challenge for Iranian vascular surgeons and our works. Iran Journal of Vascular Surgery and Endovascular Therapy. 2021;1:1418. DOI: 10.52547/ijvset.1.2.2
  41. Sadigov R. Rapid growth of the world population and its socioeconomic results. The Science World Journal. 2022;2022:8110229. DOI: 10.1155/2022/8110229
  42. Dogra S, Dunstan DW, Sugiyama T, Stathi A, Gardiner PA, Owen N. Active aging and public health: Evidence, implications, and opportunities. Annual Review of Public Health. 2022;43:439459. DOI: 10.1146/annurev-publhealth-052620-091107
  43. Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, et al. Screening for abdominal aortic aneurysm: US preventive services task force recommendation statement. JAMA. 2019;322:22112218. DOI: 10.1001/jama.2019.18928
  44. Ali MU, Fitzpatrick-Lewis D, Miller J, Warren R, Kenny M, Sherifali D, et al. Screening for abdominal aortic aneurysm in asymptomatic adults. Journal of Vascular Surgery. 2016;64:18551868. DOI: 10.1016/j.jvs.2016.05.101
  45. Duncan A, Maslen C, Gibson C, Hartshorne T, Farooqi A, Saratzis A, et al. Ultrasound screening for abdominal aortic aneurysm in high-risk women. British Journal of Surgery. 2021;108:11921198. DOI: 10.1093/bjs/znab220
  46. Sterpetti AV. Comment on: Ultrasound screening for abdominal aortic aneurysm in high-risk women. British Journal of Surgery. 2021;109:e50. DOI: 10.1093/bjs/znab435
  47. Force UPST. Screening for abdominal aortic aneurysm: US preventive services task force recommendation statement. JAMA. 2019;322:22112218. DOI: 10.1001/jama.2019.18928
  48. Ulug P, Powell JT, Sweeting MJ, Bown MJ, Thompson SG. Meta-analysis of the current prevalence of screen-detected abdominal aortic aneurysm in women. British Journal of Surgery. 2016;103:10971104. DOI: 10.1002/bjs.10225
  49. Koncar IB, Jovanovic A, Kostic O, Roganovic A, Jelicic D, Ducic S, et al. Screening men and women above the age of 50 years for abdominal aortic aneurysm: A pilot study in an upper middle income country. European Journal of Vascular & Endovascular Surgery. 2024;68:1015. DOI: 10.1016/j.ejvs.2024.03.003
  50. Png CYM, Pendleton AA, Altreuther M, Budtz-Lilly JW, Gunnarsson K, Kan CD, et al. Effect of EVAR on international ruptured AAA mortality—sex and geographic disparities. Journal of Clinical Medicine. 2024;13:2464. DOI: 10.3390/jcm13092464
  51. Anthony L, Gillies M, Goh D. Trends in AAA repair in australia over twenty years. Vascular Health and Risk Management. 2024;20:6975. DOI: 10.2147/VHRM.S449375
  52. Mell MW. Opportunities for improving population-based management of abdominal aortic aneurysms. Circulation. 2017;136:17351736. DOI: 10.1161/CIRCULATIONAHA.117.030941
DOI: https://doi.org/10.5334/gh.1517 | Journal eISSN: 2211-8179
Language: English
Submitted on: May 7, 2025
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Accepted on: Jan 5, 2026
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Published on: Jan 21, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 YouFu Wang, YiMing Su, Han Yang, WenHong Jiang, Xiao Qin, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.