Combination of Markers, Including hsCRP, TGFβ 1, IL-6, and T-regs, and their Predictive Value as Early Warning Signs for Preeclampsia: Insights from a Tertiary Care Medical Centre in Eastern India

Prakruti Dash; Bharath Kumar Koppisetty; Saubhagya Kumar Jena; Saurav Nayak

doi:10.34763/jmotherandchild.20263001.d-25-00031

References

Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco RPV, et al. Pre-eclampsia. Nat Rev Dis Primers. 2023 Feb 16;9(1):8. doi: 10.1038/s41572-023-00417-6. Erratum in: Nat Rev Dis Primers. 2023 Jul 3;9(1):35. doi: 10.1038/s41572-023-00451-4.
Open DOI Search in Google Scholar Back to article
Mathew R, Devanesan BP, Srijana, Sreedevi NS. Prevalence of hypertensive disorders of pregnancy, associated factors and pregnancy complications in a primigravida population. Gynecology and Obstetics Clinical Medicine. 2023 Jun;3(2):119–23. doi: 10.1016/j.gocm.2023.01.002.
Open DOI Search in Google Scholar Back to article
Boij R, Mjösberg J, Svensson-Arvelund J, Hjorth M, Berg G, Matthiesen L, et al. Regulatory T-cell Subpopulations in Severe or Early-onset Preeclampsia. Am J Reprod Immunol. 2015 Oct;74(4):368–78. doi: 10.1111/aji.12410. Epub 2015 Jun 27.
Open DOI Search in Google Scholar Back to article
Darmochwal-Kolarz D, Leszczynska-Gorzelak B, Rolinski J, Oleszczuk J. T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 1999 Oct;86(2):165–70. doi: 10.1016/s0301-2115(99)00065-2.
Open DOI Search in Google Scholar Back to article
Saito S, Sasaki Y, Sakai M. CD4(+)CD25 high regulatory T cells in human pregnancy. J Reprod Immunol. 2005 Apr;65(2):111–20. doi: 10.1016/j.jri.2005.01.004.
Open DOI Search in Google Scholar Back to article
Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25 high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 1;167(3):1245–53. doi: 10.4049/jimmunol.167.3.1245.
Open DOI Search in Google Scholar Back to article
Graham CH, Lysiak JJ, McCrae KR, Lala PK. Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation. Biol Reprod. 1992 Apr;46(4):561–72. doi: 10.1095/biolreprod46.4.561.
Open DOI Search in Google Scholar Back to article
Zhao MR, Qiu W, Li YX, Zhang ZB, Li D, Wang YL. Dual effect of transforming growth factor β1 on cell adhesion and invasion in human placenta trophoblast cells. Reproduction. 2006 Aug;132(2):333–41. doi: 10.1530/rep.1.01112.
Open DOI Search in Google Scholar Back to article
Yang D, Dai F, Yuan M, Zheng Y, Liu S, Deng Z, et al. Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy. Front Immunol. 2021 Aug 31;12:689181. doi: 10.3389/fimmu.2021.689181.
Open DOI Search in Google Scholar Back to article
Lamarca B, Brewer J, Wallace K. IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate? Int J Interferon Cytokine Mediat Res. 2011 Jul 1;2011(3):59–64. doi: 10.2147/IJICMR.S16320.
Open DOI Search in Google Scholar Back to article
Aggarwal R, Jain AK, Mittal P, Kohli M, Jawanjal P, Rath G. Association of pro- and anti-inflammatory cytokines in preeclampsia. J Clin Lab Anal. 2019 May;33(4):e22834. doi: 10.1002/jcla.22834. Epub 2019 Jan 21.
Open DOI Search in Google Scholar Back to article
Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology. 2004 May;112(1):38–43. doi: 10.1111/j.1365-2567.2004.01869.x.
Open DOI Search in Google Scholar Back to article
Heikkinen J, Möttönen M, Alanen A, Lassila O. Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol. 2004 May;136(2):373–8. doi: 10.1111/j.1365-2249.2004.02441.x.
Open DOI Search in Google Scholar Back to article
Steinborn A, Haensch GM, Mahnke K, Schmitt E, Toermer A, Meuer S, et al. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia? Clin Immunol. 2008 Dec;129(3):401–12. doi: 10.1016/j.clim.2008.07.032. Epub 2008 Sep 21.
Open DOI Search in Google Scholar Back to article
Wegienka G, Havstad S, Bobbitt KR, Woodcroft KJ, Zoratti EM, Ownby DR, et al. Within-woman change in regulatory T cells from pregnancy to the postpartum period. J Reprod Immunol. 2011 Jan;88(1):58–65. doi: 10.1016/j.jri.2010.06.157. Epub 2010 Oct 18.
Open DOI Search in Google Scholar Back to article
Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol. 2004 Mar;5(3):266–71. doi: 10.1038/ni1037. Epub 2004 Feb 1.
Open DOI Search in Google Scholar Back to article
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235–8. doi: 10.1038/nature04753. Epub 2006 Apr 30.
Open DOI Search in Google Scholar Back to article
Rahimzadeh M, Norouzian M, Arabpour F, Naderi N. Regulatory T-cells and preeclampsia: an overview of literature. Expert Rev Clin Immunol. 2016;12(2):209–27. doi: 10.1586/1744666X.2016.1105740. Epub 2015 Nov 18.
Open DOI Search in Google Scholar Back to article
Sasaki Y, Darmochwal-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T, et al. Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia. Clin Exp Immunol. 2007 Jul;149(1):139–45. doi: 10.1111/j.1365-2249.2007.03397.x. Epub 2007 Apr 25.
Open DOI Search in Google Scholar Back to article
LaMarca BB, Bennett WA, Alexander BT, Cockrell K, Granger JP. Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha. Hypertension. 2005 Oct;46(4):1022–5. doi: 10.1161/01.HYP.0000175476.26719.36. Epub 2005 Sep 6.
Open DOI Search in Google Scholar Back to article
LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension. 2005 Jul;46(1):82–6. doi: 10.1161/01.HYP.0000169152.59854.36. Epub 2005 May 31.
Open DOI Search in Google Scholar Back to article
Gadonski G, LaMarca BB, Sullivan E, Bennett W, Chandler D, Granger JP. Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6. Hypertension. 2006 Oct;48(4):711–6. doi: 10.1161/01.HYP.0000238442.33463.94. Epub 2006 Aug 28.
Open DOI Search in Google Scholar Back to article

Combination of Markers, Including hsCRP, TGFβ 1, IL-6, and T-regs, and their Predictive Value as Early Warning Signs for Preeclampsia: Insights from a Tertiary Care Medical Centre in Eastern India

References

Paradigm

My account