Use of Topical Nitroglycerin in the Treatment of Acute Limb Ischemia: Four-Year Experience in a Mixed Neonatal and Pediatric Intensive Care Unit

Ana Rita Jesus; Ana Rita Fradique; Catarina Teixeira; Leonor Carvalho; Teresa Dionísio

doi:10.34763/jmotherandchild.20263001.d-25-00039

Abstract

Background

Pediatric Acute Limb Ischemia (ALI) is a rare condition, sometimes encountered in the Intensive Care Unit (ICU). Optimal treatment remains to be established. Topical nitroglycerin has been suggested as a vasodilator agent, used to improve limb reperfusion.

Materials and Methods

We performed a retrospective descriptive study, with data from a PICU of a tertiary hospital, from 2021 to 2024.

Results

Seven children presented with ALI treated with topical nitroglycerin, with a median age of 244 days. Wrongful arterial catheterization was established as the cause of ALI in four out of seven children. Six out of seven children showed at least partial recovery. Complete recovery was achieved in three children. Three children underwent partial or total amputation. No adverse side effects were recorded.

Conclusion

Topical nitroglycerin appears to be a beneficial and safe intervention in children with ALI.

References

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