Have a personal or library account? Click to login
Immune Response and Lipid Metabolism Genes Associated with Acute Cerebral Circulatory Failure in Pre-Eclampsia in a Central Asian Population Cover

Immune Response and Lipid Metabolism Genes Associated with Acute Cerebral Circulatory Failure in Pre-Eclampsia in a Central Asian Population

Open Access
|Nov 2025

References

  1. Bodykov GZ, Kurmanova AM. Analysis of critical obstetric conditions in a metropolis. Bull Sci Pract. 2021;7(10):193–7. doi: 10.33619/2414-2948/71/20
  2. Zheng D, Khan M, Zhang G, Song K, Wang L, Qiao C, et al. A bibliometric analysis of the research on preeclampsia in the first two decades of the twenty-first century. J Hypertens. 2022;40(6):1126–64. doi: 10.1097/HJH.0000000000003114
  3. Mitrokhin DA, Ibragimov MM, Simbinova AN, Buirakulova NS, Kharchenko VV, Baidildaev AA, Rubanov IG. Clinical and electrophysiological indicators of acute and early recovery periods of cerebral stroke. Bull Kazakh Natl Med Univ. 2021;3:50–5. doi: 10.53065/kaznmu.2021.58.3
  4. Slobodchikova TS, Amirbekova ZhT, Taizhanova DZh. Molecular genetic markers of early diagnosis of preeclampsia. Med Ecol. 2020;2:21–33. https://medecol.qmu.kz/jour/article/view/176/175
  5. Espenbetova MZh, Sarsebaeva GS, Mikhailova DA, Nurtazanova ZhB, Beisekenova DK. Visceral obesity in pregnant women as one of the main causes of preeclampsia (literature review). Sci Bull. 2023;3(4(61)):338–43. https://www.xn----8sbempclcwd3bmt.xn--p1ai/archiv/journal-4-61-3.pdf
  6. Maulenkul T, Kuandyk A, Makhadiyeva D, Dautova A, Terzic M, Oshibayeva A, et al. Understanding the impact of endometriosis on women’s life: An integrative review of systematic reviews. BMC Wom Health. 2024;24(1):524. doi: 10.1186/s12905-024-03369-5
  7. Tulewicz-Marti EM, Lewandowski K, Rydzewska G. Bone metabolism alteration in patients with inflammatory bowel disease. J Clin Med. 2022;11(14):4138. doi: 10.3390/jcm11144138
  8. Tarasyuk BA, Mostovenko RV, Berezenko VS, Dyba MB. An effect of iron metabolism on the pronouncedness of ultrasound markers of hepatic fibrosis in children with chronic hepatitis C. Vop Prakt Pediatr. 2013;8(1):14–19.
  9. Nurgazina AS, Slyamkhanova NS, Shalgumbaeva GM. Risk factors for the development of preeclampsia in women of Semey city, East Kazakhstan region. Sci Health Care. 2020;2:109–17. https://newjournal.ssmu.kz/publication/418/-25/
  10. Wainstock T, Sergienko R, Sheiner E. Who is at risk for preeclampsia? Risk factors for developing initial preeclampsia in a subsequent pregnancy. J Clin Med. 2020;9(4):1103. doi: 10.3390/jcm9041103
  11. Okassova AK, Ilderbayev OZ, Nursafina AZh, Zharmakhanova GM, Rakhimova BB, Bayan YT, et al. Evaluation of lipid peroxidation under immobilization stress in irradiated animals in experiment. Open Access Maced J Med Sci. 2021;9:119–122. doi: 10.3889/oamjms.2021.5781
  12. Ilderbayeva G, Zhetpisbaev B, Ilderbayev О, Taldykbayev Zh, Bekeeva S. Metabolic processes of organism in remote period after the combined effects of radiation and emotional stress. Georg Med News. 2016;(250):76–82.
  13. Maltsev DV. Features of folate cycle disorders in children with ASD. Bangladesh J Med Sci. 2020;19(4):737–742. doi: 10.3329/bjms.v19i4.46634
  14. Tulewicz-Marti EM, Lewandowski K, Szczubelek M, Rydzewska G. Management of anaemia in patients with inflammatory bowel disease - results of a questionnaire among Polish healthcare professionals. Przegl Gastroenterol. 2021;16(1):89–94. doi: 10.5114/pg.2021.104738
  15. Díaz-Pérez A, Redondo Cantillo TM, Córdoba Ramos SM, Franco Novella H. Clinical correlations of serum lactate levels in patients with preeclampsia with severe symptoms. Gac Med Caracas. 2024;132(4):950–960. doi: 10.47307/GMC.2024.132.4.8
  16. Villamizar DM, Dulcey-Sarmiento LA, Theran-Leon JS, Contreras Juan AG, Gómez JA, Contreras MCG, et al. Cardiovascular risk assessment using three scales in a cohort of South American patients with COPD. Gac Med Caracas. 2024;132(1):124–131. doi: 10.47307/GMC.2024.132.1.12
  17. 1000 Genomes Project. 2021. https://www.internationalgenome.org/
  18. Kasian S, Loboda A, Smiyan O, Popov S, Petrashenko V, Zahorodnii M, et al. The lead content in biological media term infants with hypoxic-ischemic CNS. Bangladesh J Med Sci. 2021;20(2):330–333. doi: 10.3329/bjms.v20i2.51543
  19. Smiyan O, Lyndin M, Romaniuk O, Sikora V, Piddubnyi A, Yurchenko A, et al. The case of undiagnosed immunodeficiency in child from mother with leukemia anamnesis. Interventional Med Appl Sci. 2018;10(4):216–221. doi: 10.1556/1646.10.2018.46
  20. Sagindykova AA, Bazylbekova ZO, Sagindykova BA. Ways of prognosis and reduction of obstetric and perinatal complications at pregnancy chronic pyelonephritis. Biomed Pharm J. 2017;10(2):535–547. doi: 10.13005/bpj/1139
  21. Sun M, Jiang H, Meng T, Liu P, Chen H. Association between TLR4 gene polymorphisms and risk of preeclampsia: Systematic review and meta-analysis. Med Sci Monit. 2021;27:e930438. doi: 10.12659/MSM.930438
  22. Lind NA, Rael VE, Pestal K, Liu B, Barton GM. Regulation of the nucleic acid-sensing toll-like receptors. Nat Rev Immunol. 2022;22(3):224–35. doi: 10.1038/s41577-021-00577-0
  23. Firmal P, Shah VK, Chattopadhyay S. Insight into TLR4-mediated immunomodulation in normal pregnancy and related disorders. Front Immunol. 2020;11:807. doi: 10.3389/fimmu.2020.00807
  24. Romão-Veiga M, Bannwart-Castro CF, Borges VTM, Golim MA, Peraçoli JC, Peraçoli MTS. Increased TLR4 pathway activation and cytokine imbalance led to lipopolysaccharide tolerance in monocytes from preeclamptic women. Preg Hypertens. 2020;21:159–65. doi: 10.1016/j.preghy.2020.06.002
  25. Katsafanas A, Bushnell C. Pregnancy and stroke risk in women. Neurobiol Dis. 2022;169:105735. doi: 10.1016/j.nbd.2022.105735
  26. Dong J, Wang M, Gao J, Liu J, Chen Y. Association between the levels of CGI-58 and lipoprotein lipase in the placenta of patients with preeclampsia. Exp Ther Med. 2021;22(4):1129. doi: 10.3892/etm.2021.10563
  27. Golawski M, Lejawa M, Osadnik T, Mickiewicz A, Gierlotka M, Jozwiak J, et al. Genetically determined lipoprotein(a) levels do not cause an increased risk of preeclampsia – A two-sample Mendelian randomization study. Eur Heart J. 2023;44(2):ehad655.2728. doi: 10.1093/eurheartj/ehad655.2728
  28. Kadhim A, AL-Smaism M, Al-Hilli N. Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia. Int J Health Sci. 2022;6(S6):8000–5. doi: 10.53730/ijhs.v6ns6.12195
  29. Lekva T, Sugulle M, Moe K, Redman C, Dechend R, Staff A. Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes. Hypertension. 2020;75(6):1513–22. doi: 10.1161/HYPERTENSIONAHA.119.14580
  30. Thakoordeen-Reddy S, Winkler C, Moodley J, David V, Binns-Roemer E, Ramsuran V, et al. Maternal variants within the apolipoprotein L1 gene are associated with preeclampsia in a South African cohort of African ancestry. Eur J Obstet Gynecol Reprod Biol. 2020;246:129–33. doi: 10.1016/j.ejogrb.2020.01.034
  31. Zhou Z, Wang X, Chen G. ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia. Eur Rev Med Pharmacol Sci. 2022;26(4):1255–62. doi: 10.26355/eurrev_202202_28118
  32. Zou AX, Zhu FX, Jiang MX, Bao D. Correlations of CYP11B2 gene polymorphisms with eclampsia. Eur Rev Med Pharmacol Sci. 2020;24(20):10338–45. doi: 10.26355/eurrev_202010_23381
  33. Xu HL, Cui J, Jia R, Liu X, Wang YJ. Relationship between onset of eclampsia and AGTR1 gene polymorphisms. Eur Rev Med Pharmacol Sci. 2020;24(24):12638–44. doi: 10.26355/eurrev_202012_24160
  34. Ferreira LC, Gomes CEM, Duggal P, Holanda IP, Lima AS, Nascimento PRP, et al. Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women. Sci Rep. 2021;11:6764. doi: 10.1038/s41598-021-86240-z
  35. Senderek J. PLEKHG5: Merging phenotypes and disease mechanisms in Charcot-Marie-Tooth neuropathy and lower motor neuron disease. Eur J Neurol. 2021;28(4):1106–7. doi: 10.1111/ene.14752
DOI: https://doi.org/10.34763/jmotherandchild.20252901.d-25-00019 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488
Language: English
Page range: 114 - 125
Submitted on: May 13, 2025
Accepted on: Jul 25, 2025
Published on: Nov 14, 2025
Published by: Institute of Mother and Child
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Dinara Mirzakhmetova, Gulnara Svyatova, Galina Berezina, Alexandra Murtazaliyeva, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.