Immune Response and Lipid Metabolism Genes Associated with Acute Cerebral Circulatory Failure in Pre-Eclampsia in a Central Asian Population
Abstract
Background
The aim of this study was to determine the association of immune response and lipid metabolism genes with the development of pre-eclampsia and related acute cerebral circulatory disorders in Kazakh women.
Materials and methods
Minor allele frequencies of immune response and lipid metabolism genes were determined in 1,800 healthy participants stored in the Miras Biobank of the Scientific Centre of Obstetrics, Gynaecology, and Perinatology Joint Stock Company.
Results
The main results of the study showed that TLR4 (rs4986790), PLEKHA1 (rs2281673), PLEKHG1 (rs9478812), APOE (rs7412), FTO (rs1421085) and LPL (rs285) genes were in genetic equilibrium (p > 0.05), indicating that the sample was representative and there were no significant evolutionary pressures on the studied genes. The frequencies of minor alleles in the studied sample of Kazakhs were: TLR4 – 3.3%, PLEKHA1 – 5.9%, PLEKHG1 – 27.0%, APOE – 7.8%, FTO – 28.3% and LPL – 36.0%.
Conclusion
The obtained data can be used for further genetic studies, as well as for the development of individualised strategies for the prevention and treatment of pre-eclampsia and related complications. The identified genetic markers may help in early detection of women at increased risk of developing these conditions, which will contribute to improving clinical outcomes and reducing maternal and perinatal mortality.
© 2025 Dinara Mirzakhmetova, Gulnara Svyatova, Galina Berezina, Alexandra Murtazaliyeva, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.