Correspondence of genotype distribution to Hardy-Weinberg equilibrium genes associated with the development of acute cerebral circulatory failure in pre-eclampsia in the Kazakh population_
| Gene name | rs | N | GENO | O(HET) | E(HET) | p |
|---|---|---|---|---|---|---|
| Immune response genes | ||||||
| TLR4 | rs4986790 | 1801 | 1683/117/1 | 0.06496 | 0.06389 | 0.7201 |
| PLEKHA1 | rs 2281673 | 1800 | 1589/208/3 | 0.1156 | 0.1118 | 0.2046 |
| PLEKHG1 | rs 9478812 | 1798 | 935/727/136 | 0.4043 | 0.4013 | 0.7691 |
| Lipid metabolism genes | ||||||
| APOE | rs 7412 | 1801 | 1531/259/11 | 0.1438 | 0.1439 | 1 |
| FTO | rs 1421085 | 1798 | 932/713/153 | 0.3966 | 0.4061 | 0.3236 |
| LPL | rs 285 | 1801 | 709/867/225 | 0.4814 | 0.4639 | 0.1155 |
| ZNF 831 | rs 6015450 | 1801 | 1632/164/5 | 0.09106 | 0.09195 | 0.6064 |
Frequencies of minor alleles of GWAS SNPs associated with acute cerebral circulatory failure in pre-eclampsia in the Kazakh population_
| Gene name | r | MAF | N | A1 | A2 | GENO |
|---|---|---|---|---|---|---|
| Immune response genes | ||||||
| TLR4 | rs4986790 | 0.033 | 1801 | A | G | 1683/117/1 |
| PLEKHA1 | rs 2281673 | 0.059 | 1800 | T | A | 1589/208/3 |
| PLEKHG1 | rs 9478812 | 0.270 | 1798 | G | A | 935/727/136 |
| Lipid metabolism genes | ||||||
| APOE | rs 7412 | 0.078 | 1801 | T | C | 1531/259/11 |
| FTO | rs 1421085 | 0.280 | 1798 | T | C | 932/713/153 |
| LPL | rs 285 | 0.360 | 1801 | T | C | 709/867/225 |
Comparative analysis of allele frequencies of immune response and lipid metabolism genes in the Kazakh population of GWAS associated with the development of acute cerebral circulatory failure in pre-eclampsia with populations of the world countries_
| Population | N | MAF | χ2 | R |
|---|---|---|---|---|
| Immune response genes | ||||
| TLR4 (rs4986790) | ||||
| Kazakhstan | 1801 | 0.033 | ||
| Europe | 503 | 0.057 | 4.487 | 0.035 |
| East Asia | 504 | 0 | 17.239 | <0.001 |
| South Asia | 489 | 0.12 | 59.549 | <0.001 |
| PLEKHA1 (rs2281673) | ||||
| Kazakhstan | 1800 | 0.059 | ||
| Europe | 503 | 0 | 31.050 | <0.001 |
| East Asia | 504 | 0.13 | 29.601 | <0.001 |
| South Asia | 489 | 0.082 | 3.380 | 0.066 |
| PLEKHG1 (rs9478812) | ||||
| Kazakhstan | 1798 | 0.27 | ||
| Europe | 503 | 0.21 | 7.170 | 0.008 |
| East Asia | 504 | 0.52 | 112.329 | <0.001 |
| South Asia | 489 | 0.28 | 0.211 | 0.647 |
| Lipid metabolism genes | ||||
| APOE (rs7412) | ||||
| Kazakhstan | 1801 | 0.078 | ||
| Europe | 503 | 0.063 | 1.134 | 0.287 |
| East Asia | 504 | 0.10 | 2.400 | 0.122 |
| South Asia | 489 | 0.044 | 6.273 | 1 |
| FTO (rs1421085) | ||||
| Kazakhstan | 1798 | 0.28 | ||
| Europe | 503 | 0.43 | 40.982 | <0.001 |
| East Asia | 504 | 0.16 | 29.463 | <0.001 |
| South Asia | 489 | 0.30 | 0.822 | 0.365 |
| LPL (rs285) | ||||
| Kazakhstan | 1801 | 0.36 | ||
| Europe | 503 | 0.48 | 23.625 | <0.001 |
| East Asia | 504 | 0.66 | 145.862 | <0.001 |
| South Asia | 489 | 0.59 | 85.036 | <0.001 |