Have a personal or library account? Click to login

Molecular Epidemiology of mcr-1-Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China

Open Access
|Sep 2024

References

  1. Al Mana H, Johar AA, Kassem II, Eltai NO. Transmissibility and persistence of the plasmid-borne mobile colistin resistance gene, mcr-1, harbored in poultry-associated E. coli. Antibiotics. 2022 Jun; 11(6):774. https://doi.org/10.3390/antibiotics11060774
    Al Mana H Johar AA Kassem II Eltai NO. Transmissibility and persistence of the plasmid-borne mobile colistin resistance gene, mcr-1, harbored in poultry-associated E. coli . Antibiotics . 2022 Jun ; 11 ( 6 ): 774 . https://doi.org/10.3390/antibiotics11060774
  2. Alikhan NF, Petty NK, Ben Zakour NL, Beatson SA. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics. 2011 Aug;12:402. https://doi.org/10.1186/1471-2164-12-402
    Alikhan NF Petty NK Ben Zakour NL Beatson SA. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons . BMC Genomics . 2011 Aug ; 12 : 402 . https://doi.org/10.1186/1471-2164-12-402
  3. Arafi V, Hasani A, Sadeghi J, Varshochi M, Poortahmasebi V, Hasani A, Hasani R. Uropathogenic Escherichia coli endeavors: An insight into the characteristic features, resistance mechanism, and treatment choice. Arch Microbiol. 2023 May;205(6):226. https://doi.org/10.1007/s00203-023-03553-5
    Arafi V Hasani A Sadeghi J Varshochi M Poortahmasebi V Hasani A Hasani R. Uropathogenic Escherichia coli endeavors: An insight into the characteristic features, resistance mechanism, and treatment choice . Arch Microbiol . 2023 May ; 205 ( 6 ): 226 . https://doi.org/10.1007/s00203-023-03553-5
  4. Bastidas-Caldes C, Cisneros-Vásquez E, Zambrano A, Mosquera-Maza A, Calero-Cáceres W, Rey J, Yamamoto Y, Yamamoto M, Calvopiña M, de Waard JH. Co-harboring of beta-lactamases and mcr-1 genes in Escherichia coli and Klebsiella pneumoniae from healthy carriers and backyard animals in rural communities in Ecuador. Antibiotics. 2023 May;12(5):856. https://doi.org/10.3390/antibiotics12050856
    Bastidas-Caldes C Cisneros-Vásquez E Zambrano A Mosquera-Maza A Calero-Cáceres W Rey J Yamamoto Y Yamamoto M Calvopiña M de Waard JH. Co-harboring of beta-lactamases and mcr-1 genes in Escherichia coli and Klebsiella pneumoniae from healthy carriers and backyard animals in rural communities in Ecuador . Antibiotics . 2023 May ; 12 ( 5 ): 856 . https://doi.org/10.3390/antibiotics12050856
  5. Berglund B, Chen B, Tärnberg M, Sun Q, Xu L, Welander J, Li Y, Bi Z, Nilsson M, Nilsson LE. Characterization of extended-spectrum β-lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China. Future Microbiol. 2018 Nov;13:1647–1655. https://doi.org/10.2217/fmb-2018-0242
    Berglund B Chen B Tärnberg M Sun Q Xu L Welander J Li Y Bi Z Nilsson M Nilsson LE. Characterization of extended-spectrum β-lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China . Future Microbiol . 2018 Nov ; 13 : 1647 1655 . https://doi.org/10.2217/fmb-2018-0242
  6. Bi Z, Berglund B, Sun Q, Nilsson M, Chen B, Tärnberg M, Ding L, Stålsby Lundborg C, Bi Z, et al. Prevalence of the mcr-1 colistin resistance gene in extended-spectrum ß-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China. Int J Antimicrob Agents. 2017 Apr;49(4):493–497. https://doi.org/10.1016/j.ijantimicag.2016.12.018
    Bi Z Berglund B Sun Q Nilsson M Chen B Tärnberg M Ding L Stålsby Lundborg C Bi Z Prevalence of the mcr-1 colistin resistance gene in extended-spectrum ß-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China . Int J Antimicrob Agents . 2017 Apr ; 49 ( 4 ): 493 497 . https://doi.org/10.1016/j.ijantimicag.2016.12.018
  7. Binsker U, Käsbohrer A, Hammerl JA. Global colistin use: A review of the emergence of resistant Enterobacterales and the impact on their genetic basis. FEMS Microbiol Rev. 2022 Feb;46(1):fuab049. https://doi.org/10.1093/femsre/fuab049
    Binsker U Käsbohrer A Hammerl JA. Global colistin use: A review of the emergence of resistant Enterobacterales and the impact on their genetic basis . FEMS Microbiol Rev . 2022 Feb ; 46 ( 1 ): fuab049 . https://doi.org/10.1093/femsre/fuab049
  8. Cao XL, Shen H, Xu YY, Xu XJ, Zhang ZF, Cheng L, Chen JH, Arakawa Y. High prevalence of fosfomycin resistance gene fosA3 in blactx-m-harbouring Escherichia coli from urine in a Chinese tertiary hospital during 2010–2014. Epidemiol Infect. 2017 Mar; 145(4):818–824. https://doi.org/10.1017/s0950268816002879
    Cao XL Shen H Xu YY Xu XJ Zhang ZF Cheng L Chen JH Arakawa Y. High prevalence of fosfomycin resistance gene fosA3 in blactx-m-harbouring Escherichia coli from urine in a Chinese tertiary hospital during 2010–2014 . Epidemiol Infect . 2017 Mar ; 145 ( 4 ): 818 824 . https://doi.org/10.1017/s0950268816002879
  9. Carattoli A, Zankari E, García-Fernández A, Voldby Larsen M, Lund O, Villa L, Møller Aarestrup F, Hasman H. In silico detection and typing of plasmids using Plasmid Finder and plasmid multilocus sequence typing. Antimicrob Agents Chemother. 2014 Jul;58(7):3895–3903. https://doi.org/10.1128/aac.02412-14
    Carattoli A Zankari E García-Fernández A Voldby Larsen M Lund O Villa L Møller Aarestrup F Hasman H. In silico detection and typing of plasmids using Plasmid Finder and plasmid multilocus sequence typing . Antimicrob Agents Chemother . 2014 Jul ; 58 ( 7 ): 3895 3903 . https://doi.org/10.1128/aac.02412-14
  10. Chan WS, Au CH, Ho DN, Chan TL, Ma ES, Tang BS. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong. BMC Infect Dis. 2018 Feb;18(1):81. https://doi.org/10.1186/s12879-018-2987-y
    Chan WS Au CH Ho DN Chan TL Ma ES Tang BS. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong . BMC Infect Dis . 2018 Feb ; 18 ( 1 ): 81 . https://doi.org/10.1186/s12879-018-2987-y
  11. Chen J, Wang D, Ding Y, Zhang L, Li X. Molecular epidemiology of plasmid-mediated fosfomycin resistance gene determinants in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae isolates in China. Microb Drug Resist. 2019 Mar;25(2):251–257. https://doi.org/10.1089/mdr.2018.0137
    Chen J Wang D Ding Y Zhang L Li X. Molecular epidemiology of plasmid-mediated fosfomycin resistance gene determinants in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae isolates in China . Microb Drug Resist . 2019 Mar ; 25 ( 2 ): 251 257 . https://doi.org/10.1089/mdr.2018.0137
  12. Chen R, Wang G, Wang Q, Zhang M, Wang Y, Wan Z, Si Z, Bai Y, Song Z, Lu X, et al. Antimicrobial resistance and molecular epidemiology of carbapenem-resistant Escherichia coli from urinary tract infections in Shandong, China. Int Microbiol. 2023 Nov;26(4):1157–1166. https://doi.org/10.1007/s10123-023-00369-7
    Chen R Wang G Wang Q Zhang M Wang Y Wan Z Si Z Bai Y Song Z Lu X Antimicrobial resistance and molecular epidemiology of carbapenem-resistant Escherichia coli from urinary tract infections in Shandong, China . Int Microbiol . 2023 Nov ; 26 ( 4 ): 1157 1166 . https://doi.org/10.1007/s10123-023-00369-7
  13. Chotinantakul K, Chusri P, Okada S. Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand. PeerJ. 2022 Nov;10:e14408. https://doi.org/10.7717/peerj.14408
    Chotinantakul K Chusri P Okada S. Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand . PeerJ . 2022 Nov ; 10 : e14408 . https://doi.org/10.7717/peerj.14408
  14. CLSI. Performance standards for antimicrobial susceptibility testing. 33th ed. CLSI supplement M100. Wayne (USA): Clinical and Laboratory Standards Institute; 2023.
  15. Dadashi M, Sameni F, Bostanshirin N, Yaslianifard S, Khosravi-Dehaghi N, Nasiri MJ, Goudarzi M, Hashemi A, Hajikhani B. Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: A systematic review. J Glob Antimicrob Resist. 2022 Jun;29:444–461. https://doi.org/10.1016/j.jgar.2021.10.022
    Dadashi M Sameni F Bostanshirin N Yaslianifard S Khosravi-Dehaghi N Nasiri MJ Goudarzi M Hashemi A Hajikhani B. Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: A systematic review . J Glob Antimicrob Resist . 2022 Jun ; 29 : 444 461 . https://doi.org/10.1016/j.jgar.2021.10.022
  16. De La Cadena E, Mahecha M, Velandia AM, García-Betancur JC, Rojas LJ, Porras J, Pallares C, Villegas MV. Identification of mcr-1 genes and characterization of resistance mechanisms to colistin in Escherichia coli isolates from Colombian hospitals. Antibiotics. 2023 Mar;12(3):488. https://doi.org/10.3390/antibiotics12030488
    De La Cadena E Mahecha M Velandia AM García-Betancur JC Rojas LJ Porras J Pallares C Villegas MV. Identification of mcr-1 genes and characterization of resistance mechanisms to colistin in Escherichia coli isolates from Colombian hospitals . Antibiotics . 2023 Mar ; 12 ( 3 ): 488 . https://doi.org/10.3390/antibiotics12030488
  17. Di Francesco A, Salvatore D, Sakhria S, Bertelloni F, Catelli E, Ben Yahia S, Tlatli A. Colistin resistance genes in broiler chickens in Tunisia. Animals. 2023 Apr;13(8):1409. https://doi.org/10.3390/ani13081409
    Di Francesco A Salvatore D Sakhria S Bertelloni F Catelli E Ben Yahia S Tlatli A. Colistin resistance genes in broiler chickens in Tunisia . Animals . 2023 Apr ; 13 ( 8 ): 1409 . https://doi.org/10.3390/ani13081409
  18. Ding Y, Saw WY, Tan LWL, Moong DKN, Nagarajan N, Teo YY, Seedorf H. Extended-spectrum β-lactamase-producing and mcr-1-positive Escherichia coli from the gut microbiota of healthy Singaporeans. Appl Environ Microbiol. 2021 Sep;87(20):e0048821. https://doi.org/10.1128/aem.00488-21
    Ding Y Saw WY Tan LWL Moong DKN Nagarajan N Teo YY Seedorf H. Extended-spectrum β-lactamase-producing and mcr-1-positive Escherichia coli from the gut microbiota of healthy Singaporeans . Appl Environ Microbiol . 2021 Sep ; 87 ( 20 ): e0048821 . https://doi.org/10.1128/aem.00488-21
  19. Dong A, Liu C, Hua X, Yu Y, Guo Y, Wang D, Liu X, Chen H, Wang H, Zhu L. Bioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans. BMC Genomics. 2023 Apr; 24(1):168. https://doi.org/10.1186/s12864-023-09269-6
    Dong A Liu C Hua X Yu Y Guo Y Wang D Liu X Chen H Wang H Zhu L. Bioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans . BMC Genomics . 2023 Apr ; 24 ( 1 ): 168 . https://doi.org/10.1186/s12864-023-09269-6
  20. Fan R, Li C, Duan R, Qin S, Liang J, Xiao M, Lv D, Jing H, Wang X. Retrospective screening and analysis of mcr-1 and blandm in Gramnegative bacteria in China, 2010–2019. Front Microbiol. 2020 Feb; 11:121. https://doi.org/10.3389/fmicb.2020.00121
    Fan R Li C Duan R Qin S Liang J Xiao M Lv D Jing H Wang X. Retrospective screening and analysis of mcr-1 and blandm in Gramnegative bacteria in China, 2010–2019 . Front Microbiol . 2020 Feb ; 11 : 121 . https://doi.org/10.3389/fmicb.2020.00121
  21. Han H, Liu W, Cui X, Cheng X, Jiang X. Co-existence of mcr-1 and blandm-5 in an Escherichia coli strain isolated from the pharmaceutical industry, WWTP. Infect Drug Resist. 2020 Mar;13:851–854. https://doi.org/10.2147/idr.S245047
    Han H Liu W Cui X Cheng X Jiang X. Co-existence of mcr-1 and bla NDM-5 in an Escherichia coli strain isolated from the pharmaceutical industry, WWTP . Infect Drug Resist . 2020 Mar ; 13 : 851 854 . https://doi.org/10.2147/idr.S245047
  22. He K, Li W, Zhao B, Xu H, Pan Y, He D, Hu G, Wu H, Yuan L. Spreading advantages of coresident plasmids blactx-m-bearing IncFII and mcr-1-bearing IncI2 in Escherichia coli. Microbiol Spectr. 2022 Feb;10(1):e0170621. https://doi.org/10.1128/spectrum.01706-21
    He K Li W Zhao B Xu H Pan Y He D Hu G Wu H Yuan L. Spreading advantages of coresident plasmids blactx-m-bearing IncFII and mcr-1-bearing IncI2 in Escherichia coli . Microbiol Spectr . 2022 Feb ; 10 ( 1 ): e0170621 . https://doi.org/10.1128/spectrum.01706-21
  23. Heras J, Domínguez C, Mata E, Pascual V, Lozano C, Torres C, Zarazaga M. GelJ--a tool for analyzing DNA fingerprint gel images. BMC Bioinformatics. 2015 Aug;16:270. https://doi.org/10.1186/s12859-015-0703-0
    Heras J Domínguez C Mata E Pascual V Lozano C Torres C Zarazaga M. GelJ--a tool for analyzing DNA fingerprint gel images . BMC Bioinformatics . 2015 Aug ; 16 : 270 . https://doi.org/10.1186/s12859-015-0703-0
  24. Huang S, Wang S, Li Y, Fang M, Kou Z, Chen B, Xu L, Bi Z, Xu H, Chi X, et al. Prevalence and transmission of mobilized colistin resistance (mcr-1) gene positive Escherichia coli in healthy rural residents in Shandong province, China. Microbiol Res. 2021 Dec; 253: 126881. https://doi.org/10.1016/j.micres.2021.126881
    Huang S Wang S Li Y Fang M Kou Z Chen B Xu L Bi Z Xu H Chi X Prevalence and transmission of mobilized colistin resistance (mcr-1) gene positive Escherichia coli in healthy rural residents in Shandong province, China . Microbiol Res . 2021 Dec ; 253 : 126881 . https://doi.org/10.1016/j.micres.2021.126881
  25. Ibrahim DR, Dodd CER, Stekel DJ, Meshioye RT, Diggle M, Lister M, Hobman JL. Multidrug-resistant ESBL-producing E. coli in clinical samples from the UK. Antibiotics. 2023 Jan;12(1):169. https://doi.org/10.3390/antibiotics12010169
    Ibrahim DR Dodd CER Stekel DJ Meshioye RT Diggle M Lister M Hobman JL. Multidrug-resistant ESBL-producing E. coli in clinical samples from the UK . Antibiotics . 2023 Jan ; 12 ( 1 ): 169 . https://doi.org/10.3390/antibiotics12010169
  26. Jamil A, Zahoor MA, Nawaz Z, Siddique AB, Khurshid M. Genetic diversity of Escherichia coli coharboring mcr-1 and extended spectrum beta-lactamases from poultry. Biomed Res Int. 2022 Oct; 2022:8224883. https://doi.org/10.1155/2022/8224883
    Jamil A Zahoor MA Nawaz Z Siddique AB Khurshid M. Genetic diversity of Escherichia coli coharboring mcr-1 and extended spectrum beta-lactamases from poultry . Biomed Res Int . 2022 Oct ; 2022 : 8224883 . https://doi.org/10.1155/2022/8224883
  27. Karki D, Dhungel B, Bhandari S, Kunwar A, Joshi PR, Shrestha B, Rijal KR, Ghimire P, Banjara MR. Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples. Gut Pathog. 2021 Jul;13(1):45. https://doi.org/10.1186/s13099-021-00441-5
    Karki D Dhungel B Bhandari S Kunwar A Joshi PR Shrestha B Rijal KR Ghimire P Banjara MR. Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples . Gut Pathog . 2021 Jul ; 13 ( 1 ): 45 . https://doi.org/10.1186/s13099-021-00441-5
  28. Lee SY, Park YJ, Yu JK, Jung S, Kim Y, Jeong SH, Arakawa Y. Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3. J Antimicrob Chemother. 2012 Dec;67(12):2843–2847. https://doi.org/10.1093/jac/dks319
    Lee SY Park YJ Yu JK Jung S Kim Y Jeong SH Arakawa Y. Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3 . J Antimicrob Chemother . 2012 Dec ; 67 ( 12 ): 2843 2847 . https://doi.org/10.1093/jac/dks319
  29. Letunic I, Bork P. Interactive Tree of Life (iTOL) v6: Recent updates to the phylogenetic tree display and annotation tool. Nucleic Acids Res. 2024 Jul;52(Wl):W78–W82. https://doi.org/10.1093/nar/gkae268
    Letunic I Bork P. Interactive Tree of Life (iTOL) v6: Recent updates to the phylogenetic tree display and annotation tool . Nucleic Acids Res . 2024 Jul ; 52 ( Wl ): W78 W82 . https://doi.org/10.1093/nar/gkae268
  30. Li Q, Qian C, Zhang X, Zhu T, Shi W, Gao M, Feng C, Xu M, Lin H, Lin L, et al. Colistin resistance and molecular characterization of the genomes of mcr-1-positive Escherichia coli clinical isolates. Front Cell Infect Microbiol. 2022 May;12:854534. https://doi.org/10.3389/fcimb.2022.854534
    Li Q Qian C Zhang X Zhu T Shi W Gao M Feng C Xu M Lin H Lin L Colistin resistance and molecular characterization of the genomes of mcr-1-positive Escherichia coli clinical isolates . Front Cell Infect Microbiol . 2022 May ; 12 : 854534 . https://doi.org/10.3389/fcimb.2022.854534
  31. Li W, He Z, Di W, Xu W, Li Y, Sun B. Transposition mechanism of ISApl1-the determinant of colistin resistance dissemination. Anti-microb Agents Chemother. 2024a Mar;68(3):e0123123. https://doi.org/10.1128/aac.01231-23
    Li W He Z Di W Xu W Li Y Sun B. Transposition mechanism of ISApl1-the determinant of colistin resistance dissemination . Anti-microb Agents Chemother . 2024a Mar ; 68 ( 3 ): e0123123 . https://doi.org/10.1128/aac.01231-23
  32. Li Y, Sun X, Dong N, Wang Z, Li R. Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023. Drug Resist Updat. 2024b Jan;72:101031. https://doi.org/10.1016/j.drup.2023.101031
    Li Y Sun X Dong N Wang Z Li R. Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023 . Drug Resist Updat . 2024b Jan ; 72 : 101031 . https://doi.org/10.1016/j.drup.2023.101031
  33. Lima T, Loureiro D, Henriques A, Ramos F, Pomba C, Domingues S, da Silva GJ. Occurrence and biological cost of mcr-1-carrying plasmids co-harbouring beta-lactamase resistance genes in zoonotic pathogens from intensive animal production. Antibiotics. 2022 Oct; 11(10):1356. https://doi.org/10.3390/antibiotics11101356
    Lima T Loureiro D Henriques A Ramos F Pomba C Domingues S da Silva GJ. Occurrence and biological cost of mcr-1-carrying plasmids co-harbouring beta-lactamase resistance genes in zoonotic pathogens from intensive animal production . Antibiotics . 2022 Oct ; 11 ( 10 ): 1356 . https://doi.org/10.3390/antibiotics11101356
  34. Ling Z, Yin W, Shen Z, Wang Y, Shen J, Walsh TR. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J Antimicrob Chemother. 2020 Nov;75(11):3087–3095. https://doi.org/10.1093/jac/dkaa205
    Ling Z Yin W Shen Z Wang Y Shen J Walsh TR. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9 . J Antimicrob Chemother . 2020 Nov ; 75 ( 11 ): 3087 3095 . https://doi.org/10.1093/jac/dkaa205
  35. Liu X, Li X, Yang AW, Tang B, Jian ZJ, Zhong YM, Li HL, Li YM, Yan Q, Liang XH et al. Community fecal carriage and molecular epidemiology of extended-spectrum β-lactamase-and carbapene-mase-producing Escherichia coli from healthy children in the Central South China. Infect Drug Resist. 2022 Apr;15:1601–1611. https://doi.org/10.2147/idr.S357090
    Liu X Li X Yang AW Tang B Jian ZJ Zhong YM Li HL Li YM Yan Q Liang XH Community fecal carriage and molecular epidemiology of extended-spectrum β-lactamase-and carbapene-mase-producing Escherichia coli from healthy children in the Central South China . Infect Drug Resist . 2022 Apr ; 15 : 1601 1611 . https://doi.org/10.2147/idr.S357090
  36. Liu X, Wang Y, Cui L, Li Y, Xue F, Liu J, Wang L, Shen Y, Lv Y. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother. 2018 Jul;73(7):1786–1790. https://doi.org/10.1093/jac/dky092
    Liu X Wang Y Cui L Li Y Xue F Liu J Wang L Shen Y Lv Y. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016 . J Antimicrob Chemother . 2018 Jul ; 73 ( 7 ): 1786 1790 . https://doi.org/10.1093/jac/dky092
  37. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study. Lancet Infect Dis. 2016 Feb;16(2):161–168. https://doi.org/10.1016/s1473-3099(15)00424-7
    Liu YY Wang Y Walsh TR Yi LX Zhang R Spencer J Doi Y Tian G Dong B Huang X Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study . Lancet Infect Dis . 2016 Feb ; 16 ( 2 ): 161 168 . https://doi.org/10.1016/s1473-3099(15)00424-7
  38. Loras C, Mendes AC, Peixe L, Novais Â, Alós JI. Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain. J Glob Antimicrob Resist. 2020 Jun;21:414–416. https://doi.org/10.1016/j.jgar.2020.01.023
    Loras C Mendes AC Peixe L Novais  Alós JI. Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain . J Glob Antimicrob Resist . 2020 Jun ; 21 : 414 416 . https://doi.org/10.1016/j.jgar.2020.01.023
  39. Lu X, Zeng M, Xu J, Zhou H, Gu B, Li Z, Jin H, Wang X, Zhang W, Hu Y, et al. Epidemiologic and genomic insights on mcr-1-harbour-ing Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016. EBioMedicine. 2019 Apr;42:133–144. https://doi.org/10.1016/j.ebiom.2019.03.006
    Lu X Zeng M Xu J Zhou H Gu B Li Z Jin H Wang X Zhang W Hu Y Epidemiologic and genomic insights on mcr-1-harbour-ing Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016 . EBioMedicine . 2019 Apr ; 42 : 133 144 . https://doi.org/10.1016/j.ebiom.2019.03.006
  40. Ma J, Wang J, Feng J, Liu Y, Yang B, Li R, Bai L, He T, Wang X, Yang Z. Characterization of three porcine Acinetobacter towneri strains coharboring tet(X3) and blaoxa-58. Front Cell Infect Microbiol. 2020 Dec;10:586507. https://doi.org/10.3389/fcimb.2020.586507
    Ma J Wang J Feng J Liu Y Yang B Li R Bai L He T Wang X Yang Z. Characterization of three porcine Acinetobacter towneri strains coharboring tet(X3) and blaoxa-58 . Front Cell Infect Microbiol . 2020 Dec ; 10 : 586507 . https://doi.org/10.3389/fcimb.2020.586507
  41. Nang SC, Li M, Harper M, Mandela E, Bergen PJ, Rolain JM, Zhu Y, Velkov T, Li J. Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli. Int J Antimicrob Agents. 2022 Feb;59(2):106505. https://doi.org/10.1016/j.ijantimicag.2021.106505
    Nang SC Li M Harper M Mandela E Bergen PJ Rolain JM Zhu Y Velkov T Li J. Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli . Int J Antimicrob Agents . 2022 Feb ; 59 ( 2 ): 106505 . https://doi.org/10.1016/j.ijantimicag.2021.106505
  42. Onduru OG, Mkakosya RS, Aboud S, Rumisha SF. Genetic determinants of resistance among ESBL-producing Enterobacteriaceae in Community and Hospital Settings in East, Central, and Southern Africa: A systematic review and meta-analysis of prevalence. Can J Infect Dis Med Microbiol. 2021 Jun;2021:5153237. https://doi.org/10.1155/2021/5153237
    Onduru OG Mkakosya RS Aboud S Rumisha SF. Genetic determinants of resistance among ESBL-producing Enterobacteriaceae in Community and Hospital Settings in East, Central, and Southern Africa: A systematic review and meta-analysis of prevalence . Can J Infect Dis Med Microbiol . 2021 Jun ; 2021 : 5153237 . https://doi.org/10.1155/2021/5153237
  43. Prjibelski A, Antipov D, Meleshko D, Lapidus A, Korobeynikov A. Using SPAdes De Novo Assembler. Curr Protoc Bioinformatics. 2020 Jun;70(1):e102. https://doi.org/10.1002/cpbi.102
    Prjibelski A Antipov D Meleshko D Lapidus A Korobeynikov A. Using SPAdes De Novo Assembler . Curr Protoc Bioinformatics . 2020 Jun ; 70 ( 1 ): e102 . https://doi.org/10.1002/cpbi.102
  44. Protonotariou E, Meletis G, Malousi A, Kotzamanidis C, Tychala A, Mantzana P, Theodoridou K, Ioannidou M, Hatzipantelis E, Tsakris A, et al. First detection of mcr-1-producing Escherichia coli in Greece. J Glob Antimicrob Resist. 2022 Dec;31:252–255. https://doi.org/10.1016/j.jgar.2022.10.008
    Protonotariou E Meletis G Malousi A Kotzamanidis C Tychala A Mantzana P Theodoridou K Ioannidou M Hatzipantelis E Tsakris A First detection of mcr-1-producing Escherichia coli in Greece . J Glob Antimicrob Resist . 2022 Dec ; 31 : 252 255 . https://doi.org/10.1016/j.jgar.2022.10.008
  45. Rhouma M, Madec JY, Laxminarayan R. Colistin: From the shadows to a One Health approach for addressing antimicrobial resistance. Int J Antimicrob Agents. 2023 Feb;61(2):106713. https://doi.org/10.1016/j.ijantimicag.2023.106713
    Rhouma M Madec JY Laxminarayan R. Colistin: From the shadows to a One Health approach for addressing antimicrobial resistance . Int J Antimicrob Agents . 2023 Feb ; 61 ( 2 ): 106713 . https://doi.org/10.1016/j.ijantimicag.2023.106713
  46. Riley LW. Distinguishing pathovars from nonpathovars: Escherichia coli. Microbiol Spectr. 2020 Dec;8(4):10.1128/microbiolspec. ame-0014-2020. https://doi.org/10.1128/microbiolspec.ame-0014-2020
    Riley LW. Distinguishing pathovars from nonpathovars: Escherichia coli . Microbiol Spectr . 2020 Dec ; 8 ( 4 ): https://doi.org/10.1128/microbiolspec.ame-0014-2020
  47. Robin F, Beyrouthy R, Colot J, Saint-Sardos P, Berger-Carbonne A, Dalmasso G, Delmas J, Bonnet R. MCR-1 in ESBL-producing Escherichia coli responsible for human infections in New Caledonia. J Antimicrob Chemother. 2017 Mar;72(3):946–947. https://doi.org/10.1093/jac/dkw508
    Robin F Beyrouthy R Colot J Saint-Sardos P Berger-Carbonne A Dalmasso G Delmas J Bonnet R. MCR-1 in ESBL-producing Escherichia coli responsible for human infections in New Caledonia . J Antimicrob Chemother . 2017 Mar ; 72 ( 3 ): 946 947 . https://doi.org/10.1093/jac/dkw508
  48. Rodríguez-Santiago J, Cornejo-Juárez P, Silva-Sánchez J, Garza-Ramos U. Polymyxin resistance in Enterobacterales: Overview and epidemiology in the Americas. Int J Antimicrob Agents. 2021 Nov; 58(5):106426. https://doi.org/10.1016/j.ijantimicag.2021.106426
    Rodríguez-Santiago J Cornejo-Juárez P Silva-Sánchez J Garza-Ramos U. Polymyxin resistance in Enterobacterales: Overview and epidemiology in the Americas . Int J Antimicrob Agents . 2021 Nov ; 58 ( 5 ): 106426 . https://doi.org/10.1016/j.ijantimicag.2021.106426
  49. Rodríguez-Santiago J, Rodríguez-Medina N, Tamayo-Legorreta EM, Silva-Sánchez J, Téllez-Sosa J, Duran-Bedolla J, Aguilar-Vera A, Lecona-Valera AN, Garza-Ramos U, Alpuche-Aranda C. Molecular and genomic insights of mcr-1-producing Escherichia coli isolates from piglets. Antibiotics. 2022 Jan;11(2):157. https://doi.org/10.3390/antibiotics11020157
    Rodríguez-Santiago J Rodríguez-Medina N Tamayo-Legorreta EM Silva-Sánchez J Téllez-Sosa J Duran-Bedolla J Aguilar-Vera A Lecona-Valera AN Garza-Ramos U Alpuche-Aranda C. Molecular and genomic insights of mcr-1-producing Escherichia coli isolates from piglets . Antibiotics . 2022 Jan ; 11 ( 2 ): 157 . https://doi.org/10.3390/antibiotics11020157
  50. Shafiq M, Rahman SU, Bilal H, Ullah A, Noman SM, Zeng M, Yuan Y, Xie Q, Li X, Jiao X. Incidence and molecular characterization of ESBL-producing and colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan. J Appl Microbiol. 2022 Sep;133(3):1169–1182. https://doi.org/10.1111/jam.15469
    Shafiq M Rahman SU Bilal H Ullah A Noman SM Zeng M Yuan Y Xie Q Li X Jiao X. Incidence and molecular characterization of ESBL-producing and colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan . J Appl Microbiol . 2022 Sep ; 133 ( 3 ): 1169 1182 . https://doi.org/10.1111/jam.15469
  51. Shen Y, Wu Z, Wang Y, Zhang R, Zhou HW, Wang S, Lei L, Li M, Cai J, Tyrrell J, et al. Heterogeneous and flexible transmission of mcr-1 in hospital-associated Escherichia coli. mBio. 2018 Jul; 9(4): e00943-18. https://doi.org/10.1128/mBio.00943-18
    Shen Y Wu Z Wang Y Zhang R Zhou HW Wang S Lei L Li M Cai J Tyrrell J Heterogeneous and flexible transmission of mcr-1 in hospital-associated Escherichia coli . mBio . 2018 Jul ; 9 ( 4 ): e00943 - 18 . https://doi.org/10.1128/mBio.00943-18
  52. Shi J, Zhu H, Liu C, Xie H, Li C, Cao X, Shen H. Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates. Front Microbiol. 2023 Jan;13:1105401. https://doi.org/10.3389/fmicb.2022.1105401
    Shi J Zhu H Liu C Xie H Li C Cao X Shen H. Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates . Front Microbiol . 2023 Jan ; 13 : 1105401 . https://doi.org/10.3389/fmicb.2022.1105401
  53. Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M. IS finder: The reference centre for bacterial insertion sequences. Nucleic Acids Res. 2006 Jan;34(Suppl_1):D32-D36. https://doi.org/10.1093/nar/gkj014
    Siguier P Perochon J Lestrade L Mahillon J Chandler M. IS finder: The reference centre for bacterial insertion sequences . Nucleic Acids Res . 2006 Jan ; 34 ( Suppl_1 ): D32 D36 . https://doi.org/10.1093/nar/gkj014
  54. Stamatakis A. RAxML version 8: A tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014 May; 30(9):1312–1313. https://doi.org/10.1093/bioinformatics/btu033
    Stamatakis A. RAxML version 8: A tool for phylogenetic analysis and post-analysis of large phylogenies . Bioinformatics . 2014 May ; 30 ( 9 ): 1312 1313 . https://doi.org/10.1093/bioinformatics/btu033
  55. Szmolka A, Gellért Á, Szemerits D, Rapcsák F, Spisák S, Adorján A. Emergence and genomic features of a mcr-1 Escherichia coli from duck in Hungary. Antibiotics. 2023 Oct;12(10):1519. https://doi.org/10.3390/antibiotics12101519
    Szmolka A Gellért Á Szemerits D Rapcsák F Spisák S Adorján A. Emergence and genomic features of a mcr-1 Escherichia coli from duck in Hungary . Antibiotics . 2023 Oct ; 12 ( 10 ): 1519 . https://doi.org/10.3390/antibiotics12101519
  56. Tang B, Chang J, Chen Y, Lin J, Xiao X, Xia X, Lin J, Yang H, Zhao G. Escherichia fergusonii, an underrated repository for antimicrobial resistance in food animals. Microbiol Spectr. 2022 Feb; 10(1):e0161721. https://doi.org/10.1128/spectrum.01617-21
    Tang B Chang J Chen Y Lin J Xiao X Xia X Lin J Yang H Zhao G. Escherichia fergusonii, an underrated repository for antimicrobial resistance in food animals . Microbiol Spectr . 2022 Feb ; 10 ( 1 ): e0161721 . https://doi.org/10.1128/spectrum.01617-21
  57. Tegetmeyer HE, Jones SC, Langford PR, Baltes N. ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Vet Microbiol. 2008 Apr;128(3–4):342–353. https://doi.org/10.1016/j.vetmic.2007.10.025
    Tegetmeyer HE Jones SC Langford PR Baltes N. ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76 . Vet Microbiol . 2008 Apr ; 128 ( 3–4 ): 342 353 . https://doi.org/10.1016/j.vetmic.2007.10.025
  58. Tian X, Fang R, Wu Q, Zheng X, Zhao Y, Dong G, Wang C, Zhou T, Cao J. Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring blandm-1, mcr-1, and fosA3 from a patient in China. J Antibiot (Tokyo). 2020 Sep;73(9):636–641. https://doi.org/10.1038/s41429-020-0306-5
    Tian X Fang R Wu Q Zheng X Zhao Y Dong G Wang C Zhou T Cao J. Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring blandm-1, mcr-1, and fosA3 from a patient in China . J Antibiot (Tokyo) . 2020 Sep ; 73 ( 9 ): 636 641 . https://doi.org/10.1038/s41429-020-0306-5
  59. Vu Thi Ngoc B, Le Viet T, Nguyen Thi Tuyet M, Nguyen Thi Hong T, Nguyen Thi Ngoc D, Le Van D, Chu Thi L, Tran Huy H, Penders J, Wertheim H et al. Characterization of genetic elements carrying mcr-1 gene in Escherichia coli from the community and hospital settings in Vietnam. Microbiol Spectr. 2022 Feb;10(1):e0135621. https://doi.org/10.1128/spectrum.01356-21
    Vu Thi Ngoc B Le Viet T Nguyen Thi Tuyet M Nguyen Thi Hong T Nguyen Thi Ngoc D Le Van D Chu Thi L Tran Huy H Penders J Wertheim H Characterization of genetic elements carrying mcr-1 gene in Escherichia coli from the community and hospital settings in Vietnam . Microbiol Spectr . 2022 Feb ; 10 ( 1 ): e0135621 . https://doi.org/10.1128/spectrum.01356-21
  60. Wang Y, Xu C, Zhang R, Chen Y, Shen Y, Hu F, Liu D, Lu J, Guo Y, Xia X et al. Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: An epidemiological comparative study. Lancet Infect Dis. 2020 Oct;20(10):1161–1171. https://doi.org/10.1016/s1473-3099(20)30149-3
    Wang Y Xu C Zhang R Chen Y Shen Y Hu F Liu D Lu J Guo Y Xia X Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: An epidemiological comparative study . Lancet Infect Dis . 2020 Oct ; 20 ( 10 ): 1161 1171 . https://doi.org/10.1016/s1473-3099(20)30149-3
  61. Xie J, Liang B, Xu X, Yang L, Li H, Li P, Qiu S, Song H. Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China. J Glob Antimicrob Resist. 2022 Jun;29:88-96. https://doi.org/10.1016/j.jgar.2022.02.008
    Xie J Liang B Xu X Yang L Li H Li P Qiu S Song H. Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China . J Glob Antimicrob Resist . 2022 Jun ; 29 : 88 96 . https://doi.org/10.1016/j.jgar.2022.02.008
  62. Yin Y, Qiu L, Wang G, Guo Z, Wang Z, Qiu J, Li R. Emergence and transmission of plasmid-mediated mobile colistin resistance gene mcr-10 in humans and companion animals. Microbiol Spectr. 2022 Oct;10(5):e0209722. https://doi.org/10.1128/spectrum.02097-22
    Yin Y Qiu L Wang G Guo Z Wang Z Qiu J Li R. Emergence and transmission of plasmid-mediated mobile colistin resistance gene mcr-10 in humans and companion animals . Microbiol Spectr . 2022 Oct ; 10 ( 5 ): e0209722 . https://doi.org/10.1128/spectrum.02097-22
  63. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, Aarestrup FM, Larsen MV. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012 Nov; 67(11):2640–2644. https://doi.org/10.1093/jac/dks261
    Zankari E Hasman H Cosentino S Vestergaard M Rasmussen S Lund O Aarestrup FM Larsen MV. Identification of acquired antimicrobial resistance genes . J Antimicrob Chemother . 2012 Nov ; 67 ( 11 ): 2640 2644 . https://doi.org/10.1093/jac/dks261
  64. Zhang P, Wang J, Wang X, Bai X, Ma J, Dang R, Xiong Y, Fanning S, Bai L, Yang Z. Characterization of five Escherichia coli isolates coexpressing ESBL and mcr-1 resistance mechanisms from different origins in China. Front Microbiol. 2019 Aug;10:1994. https://doi.org/10.3389/fmicb.2019.01994
    Zhang P Wang J Wang X Bai X Ma J Dang R Xiong Y Fanning S Bai L Yang Z. Characterization of five Escherichia coli isolates coexpressing ESBL and mcr-1 resistance mechanisms from different origins in China . Front Microbiol . 2019 Aug ; 10 : 1994 . https://doi.org/10.3389/fmicb.2019.01994
  65. Zhou Y, Ai W, Cao Y, Guo Y, Wu X, Wang B, Rao L, Xu Y, Zhao H, Wang X et al. The co-occurrence of NDM-5, mcr-1, and fosa3-encoding plasmids contributed to the generation of extensively drug-resistant Klebsiella pneumoniae. Front Microbiol. 2022 Jan; 12:811263. https://doi.org/10.3389/fmicb.2021.811263
    Zhou Y Ai W Cao Y Guo Y Wu X Wang B Rao L Xu Y Zhao H Wang X The co-occurrence of NDM-5, mcr-1, and fosa3-encoding plasmids contributed to the generation of extensively drug-resistant Klebsiella pneumoniae . Front Microbiol . 2022 Jan ; 12 : 811263 . https://doi.org/10.3389/fmicb.2021.811263
DOI: https://doi.org/10.33073/pjm-2024-032 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
Language: English
Page range: 363 - 375
Submitted on: May 15, 2024
Accepted on: Jul 23, 2024
Published on: Sep 13, 2024
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year

© 2024 Yue Liu, Qian Wang, Ting Qi, Meng Zhang, Ran Chen, Zaifeng Si, Jinmei Li, Yan Jin, Qingbing Xu, Ping Li, Yingying Hao, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.