Have a personal or library account? Click to login
Pancreatic stone protein predicts hospital stay in community-acquired infections Cover

References

  1. LAGU T, ROTHBERG MB, SHIEH MS, PEKOW PS, STEINGRUB JS, LINDENAUER PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 40(3):754–761; 2012.
  2. REDING T, PALMIERE C, PAZHEPURACKEL C, SCHIESSER M, BIMMLER D, SCHLEGEL A, SÜSS U, STEINER S, MANCINA L, SELEZNIK G, GRAF R. The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII. Oncotarget. 8(18):30162–30174; 2017.
  3. KEEL M, HÄRTER L, REDING T, SUN LK, HERSBERGER M, SEIFERT B, BIMMLER D, GRAF R. Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes. Crit Care Med. 37(5):1642–1648; 2009.
  4. GARCÍA DE GUADIANA-ROMUALDO L, BERGER M, JIMÉNEZSANTOS E, REBOLLO-ACEBES S, JIMÉNEZ-SÁNCHEZ R, ESTEBAN-TORRELLA P, et al. Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department. Eur J Clin Invest. 47(4):297–304; 2017.
  5. MICHAILIDES C, LAGADINOU M, PARASKEVAS T, PAPANTONIOU K, KAVVOUSANOS M, VASILEIOU A, THOMOPOULOS K, VELISSARIS D, MARANGOS M. The role of the pancreatic stone protein in predicting intra-abdominal infection-related complications: a prospective observational single-center cohort study. Microorganisms. 11(10):2579; 2023.
  6. LAGADINOU M, PARASKEVAS T, VELISSARIS D, MICHAILIDES C, ELEFTHERAKIS G, SAMPSONAS F, SIAKALLIS G, ASSIMAKOPOULOS SF, MARANGOS M. The role of pancreatic stone protein as a prognostic factor for COVID-19 patients. Eur Rev Med Pharmacol Sci. 26(17):6391–6395; 2022.
  7. KEEL M, SCHREGENBERGER N, STECKHOLZER U, KENNEY J, et al., Pancreatic stone protein is a novel acute-phase reactant and a marker of pancreatic injury and stress. Crit Care Med. 1999;27(3):675–681.
  8. FIDALGO PN, COELHO D, POVOA P. Pancreatic stone protein: review of a new biomarker in sepsis. J Clin Med. 11(4):1085; 2022.
  9. BOECK L, GRAF R, EGGIMANN P, PARGGER H, RAPTIS DA, SMYRNIOS N, THAKKAR N, SIEGEMUND M, RAKIC J, TAMM M, STOLZ D. Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia. Chest. 140(4):925–932; 2011.
  10. VENTURA F, EGGIMANN P, DAIX T, FRANÇOIS B, PUGIN J. Pancreatic stone protein measurement to screen and diagnose sepsis in the context of the Surviving Sepsis Campaign recommendations. Medical Research Archives. 11(12); 2024.
  11. EGGIMANN P, QUE YA, REBEAUD F. Measurement of pancreatic stone protein in the identification and management of sepsis. Biomark Med. 13(2):135–145; 2019.
  12. SAWSAN ME, SUZAN OM, HEND MM, JOSEPH SZ, NAGWA IO. Serum pancreatic stone protein as a new protein biomarker for late-onset neonatal sepsis. Ann Neonatol J. 2:78–92; 2020.
  13. PRAZAK J, IRINCHEEVA I, LLEWELYN MJ. Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis. Crit Care. 25:182; 2021.
DOI: https://doi.org/10.2478/rjim-2025-0021 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 310 - 315
Submitted on: Sep 13, 2025
|
Published on: Nov 14, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Christos Michailides, Maria Lagadinou, Eleni Georgopoulou, Eirini Kechagia, Eleni-Konstantina Velissari, Nikolaos Polychronopoulos, Foteini Tasouli, Christodoulos Chatzigrigoriadis, Dimitrios Velissaris, Markos Marangos, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.