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Mortality predictors in patients with ST-segment elevation myocardial infarction presenting no-reflow phenomenon after primary PCI: experience of a tertiary center Cover

Mortality predictors in patients with ST-segment elevation myocardial infarction presenting no-reflow phenomenon after primary PCI: experience of a tertiary center

Open Access
|Aug 2025

Figures & Tables

Figure 1.

Graphical abstract revealing the pathophysiology of atherosclerosis and mortality predictors in STEMI subjects with no-reflow phenomenon
Graphical abstract revealing the pathophysiology of atherosclerosis and mortality predictors in STEMI subjects with no-reflow phenomenon

Figure 2.

Stent implantation in culprit lesions during PCI performed in STEMI subjects
Stent implantation in culprit lesions during PCI performed in STEMI subjects

Figure 3.

In-hospital mortality predicted by the no-reflow phenomenon type
In-hospital mortality predicted by the no-reflow phenomenon type

Mortality rates by sex and age in our study

WomenYearsNoDeaths
Under 50 yo30
50–70 yo111
Over 70 yo183
MenUnder 50 yo150
50–70 yo324
Over 70 yo176

Morphologic aspects of myocardial infarction in patients with STEMI and no-reflow phenomenon after primary PCI

Coronary branchTerritory affectedApproximate age of lesionNumber of cases
Left anterior descending coronary arteryAnterior and interventricular septum24–120 hours2
Left circumflex coronary arteryLateral part of the left ventricle48–72 hours1
Right coronary arteryPosterior part of the left ventricle24–96 hours2

Gross and Histological Features in STEMI Patients Exhibiting the No-Reflow Phenomenon

Macroscopy
Fig. 4.1. Posterior myocardial infarction (2–3 days old): Gross appearance with early transmural ischemic changes.Fig. 4.2. Posterolateral myocardial infarction (4–5 days old): Full-thickness infarction observed during autopsy.
Microscopy
Fig. 4.3. H&E stain, 10×: Transmural necrosis with prominent neutrophilic infiltration in the interstitial space.Fig. 4.4. H&E stain, 4×: Myocardial rupture with disorganized tissue architecture and interstitial hemorrhage.
Fig. 4.5. H&E stain, 20×: Detailed visualization of a fissure between necrotic myocardial fibers.Fig. 4.6. H&E stain, 20×: Thrombosed myocardial region accompanied by inflammatory cell infiltration and necrosis.

Complications after PCI found in STEMI patients with no-reflow phenomenon included in our study

ComplicationsNumber of patientsDeaths
Rhythm disorders
No7511
Yes213
Acute pulmonary oedema
No9110
Yes54
Left ventricular aneurysm
No9213
Yes41
Cardiogenic shock
No809
Yes165
Myocardial rupture
No9513
Yes11
DOI: https://doi.org/10.2478/rjim-2025-0016 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Submitted on: May 19, 2025
Published on: Aug 28, 2025
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Larisa Renata Pantea-Roșan, Ovidiu Țica, Otilia Anca Țica, Mircea Ioachim Popescu, Iulia Bogdan, Alexandra Buzle, Mădălina Ioana Moisi, Vlad Alin Pantea, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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