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QAOS Protocol: an echocardiographic strategy for the assessment of pacemaker-induced cardiac dyssynchrony Cover

QAOS Protocol: an echocardiographic strategy for the assessment of pacemaker-induced cardiac dyssynchrony

Open Access
|Jan 2026

Figures & Tables

Figure 1

The image acquisition process adheres to the conventional sequence of standard echocardiography. The QAOS steps are illustrated in the parasternal long-axis (PE-LAX); short-axis views (PE-SAX, at the level of the great vessels); and apical five-(Ap5C) and four-chamber (Ap4C) views.
The image acquisition process adheres to the conventional sequence of standard echocardiography. The QAOS steps are illustrated in the parasternal long-axis (PE-LAX); short-axis views (PE-SAX, at the level of the great vessels); and apical five-(Ap5C) and four-chamber (Ap4C) views.

Figure 2

Comparison of the electrocardiogram from a patient with left bundle branch block (Panel A) and the tracing from a patient with a pacemaker showing right apical stimulation (Panel B).
Comparison of the electrocardiogram from a patient with left bundle branch block (Panel A) and the tracing from a patient with a pacemaker showing right apical stimulation (Panel B).

Figure 3

Polar maps of the left ventricle with pacemaker-induced left intraventricular dyssynchrony. Acute changes are shown in a female patient studied with speckle-tracking strain echocardiography, both in native rhythm (left) and during pacing from a right ventricular apical lead (right). Left ventricular mechanical dispersion (peak strain deviation, or PSD) increased from 53 ms (normal) to 177.7 ms (severely abnormal), confirming new dyssynchrony caused by pacing.
Polar maps of the left ventricle with pacemaker-induced left intraventricular dyssynchrony. Acute changes are shown in a female patient studied with speckle-tracking strain echocardiography, both in native rhythm (left) and during pacing from a right ventricular apical lead (right). Left ventricular mechanical dispersion (peak strain deviation, or PSD) increased from 53 ms (normal) to 177.7 ms (severely abnormal), confirming new dyssynchrony caused by pacing.

Figure 4

Polar maps of the left ventricle with pacemaker-induced ventricular dysfunction. Acute changes are shown in the same patient from Figure 3, assessed with speckle-tracking strain echocardiography. Left ventricular function in native rhythm (left) and during pacing from a right ventricular apical lead (right) are compared. Left ventricular ejection fraction (EF) decreases from 53% to 43%, and global longitudinal strain (SG) drops dramatically, from -13.7% to -5.1%.
Polar maps of the left ventricle with pacemaker-induced ventricular dysfunction. Acute changes are shown in the same patient from Figure 3, assessed with speckle-tracking strain echocardiography. Left ventricular function in native rhythm (left) and during pacing from a right ventricular apical lead (right) are compared. Left ventricular ejection fraction (EF) decreases from 53% to 43%, and global longitudinal strain (SG) drops dramatically, from -13.7% to -5.1%.

Comparative Analysis with QAOS Protocol: two cases of patients with pacemakers_

Case A Male, 85 years old Ischaemic heart diseaseCase B Male, 68 years old Non-ischaemic heart disease
Heart failure symptoms?NYHA Class IINYHA Class II
RV pacing %62.3%55%
Heart RythmNative SinusVVINative Atrial Fib.VVI
LVEF (%)58%56%48%37.9%
Global Longitudinal Strain (%)-16.4%-12.5%-24.2%-15.5%
QAOS Step 1: Septal flash? (Yes/No/Not evaluable)NoYesNoYes
QAOS Step 2: LVOT area (cm2)2.27 cm23.14 cm2
QAOS Step 3: VD pre-expulsive period (ms)55 ms116 ms88 ms94 ms
QAOS Step 4: LV pre-expulsive period (ms)87 ms176 ms88 ms138 ms
QAOS Step 5: Interventricular delay (ms)32 ms60 ms044 ms
Interventricular synchrony? (Y/N)YesNoYESNo
QAOS Step 6: LVOT VTI (cm)25.2 cm14.5 cm17 cm14 cm
LV stroke volume (ml)56 ml32 ml51.5 ml44 ml
QAOS Step 7: Rocking apex: (Yes/No/Not evaluable)NoYesNOYes
Intraventricular synchrony? (Y/N)YESNoYESNO
QAOS Step 8: R–R interval (ms)1005 ms1000 ms822740 ms
QAOS Step 9: Mitral diastolic flow duration (ms)614 ms382 ms391254 ms
QAOS Step 10: Mitral diastolic flow duration ÷ R–R: (%)61.1%38.2%47.6%34.3%
A-V Synchrony? (Yes/No)YesNoYesNo
Can PIC be diagnosed?NOYES
Is there a need for a pacemaker upgrade?NOYES
DOI: https://doi.org/10.2478/rjc-2025-0040 | Journal eISSN: 2734-6382 | Journal ISSN: 1220-658X
Language: English
Published on: Jan 27, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Hugo Villarroel-Ábrego, published by Romanian Society of Cardiology
This work is licensed under the Creative Commons Attribution 4.0 License.

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