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Association between Bisphenol A exposure and dilated cardiomyopathy Cover

Association between Bisphenol A exposure and dilated cardiomyopathy

Open Access
|Jan 2026

Figures & Tables

Association between Bisphenol A and New York Heart Association classification of heart failure in patients with dilated cardiomyopathy

Dilated Cardiomyopathy with detected Bisphenol A No: 12Dilated Cardiomyopathy with non-detected Bisphenol A No: 38Chi-square testP value
New York Heart Association Class II5 (41.7%)17 (44.7%)2.50.280
New York Heart Association Class III6 (50.0%)11 (28.9%)
New York Heart Association Class IV1 (8.3%)10 (26.3%)

Comparison between dilated cardiomyopathy and healthy controls groups regarding the ECG abnormalities_

Dilated Cardiomyopathy Group No: 50Healthy Controls Group No: 30Chi-square testP value
ECG CharacteristicsNormal ECG25 (50.0%)27 (90.0%)13.20.0003
Abnormal ECG including Atrial Fibrillation, Left Bundle Branch Block, and Right Bundle Branch Block25 (50.0%)3 (10.0%)

Association between Bisphenol A and volumetric indexes of the left atrial diameter and right ventricular size and function in patients with dilated cardiomyopathy_

Dilated Cardiomyopathy with detected Bisphenol A No: 12Dilated Cardiomyopathy with non-detected Bisphenol A No: 38Independent t-testP value
Left Atrial Diameter Mean ± SD40.58 ± 4.3437.39 ± 5.553.190.050
Dilated Cardiomyopathy with detected Bisphenol ADilated Cardiomyopathy with nondetected Bisphenol AChi-square testP value
No: 12No: 38
Right Ventricle SizeDilated Right Ventricle9 (75.0%)5 (13.2%)17.3< 0.0001
Normal Right Ventricle3 (25.0%)33 (86.8%)
Dilated Cardiomyopathy with detected Bisphenol ADilated Cardiomyopathy with nondetected Bisphenol AIndependent t-testP value
No: 12No: 38
Tricuspid Annular Plane Systolic Excursion Mean ± SD14.42 ± 1.9317.58 ± 2.32–3.16< 0.0001

Comparison between dilated cardiomyopathy and healthy controls groups regarding the baseline characteristics and risk factors_

Dilated Cardiomyopathy Group No: 50Healthy Controls Group No: 30Independent t-testP value
Age Mean ± SD56.7 ± 12.858.2 ± 9.81.50.568
Dilated Cardiomyopathy GroupHealthy Controls GroupChi-square testP value
No: 50No: 30
SexFemales13 (26.0%)7 (23.3%)0.070.790
Males37 (74.0%)23 (76.7%)
ResidenceFayoum17 (34.0%)10 (33.0%)0.0040.951
Other Districts33 (66.0%)20 (66.7%)
02 (4.0%)0 (0.0%)
No: of Offspring212 (24.0%)5 (16.7%)1.990.574
313 (26.0%)9 (30.0%)
≥423 (46.0%)16 (53.3%)
Diabetes MellitusYes9 (18.0%)8 (26.7%)0.840.359
No41 (82.0%)22 (73.3%)
HypertensionYes14 (28.0%)9 (30.0%)0.03660.848
No36 (72.0%)21 (70.0%)
Ex-smokers15 (30.0%)8 (26.7%)
SmokingSmokers3 (6.0%)5 (16.7%)2.370.306
Non-smokers32 (64.0%)17 (56.7%)
Family HistoryYes9 (18.0%)8 (26.7%)0.840.359
No41 (82.0%)22 (73.3%)

Comparison between dilated cardiomyopathy and healthy controls groups regarding Bisphenol A_

Dilated Cardiomyopathy Group No: 50Healthy Controls Group No: 30Chi-square testP value
Bisphenol A detected12 (24.0%)2 (6.7%)3.90.048
Bisphenol A not detected38 (76.0%)28 (93.3%)
DOI: https://doi.org/10.2478/rjc-2025-0038 | Journal eISSN: 2734-6382 | Journal ISSN: 1220-658X
Language: English
Published on: Jan 27, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Hassan Mohamed Ebeid, Khaled Ahmed Elkhashab, Naglaa Abdel-Khalek El-Sherbiny, Moustafa Kamal Eldin Ibrahim Khalil Saad, published by Romanian Society of Cardiology
This work is licensed under the Creative Commons Attribution 4.0 License.

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