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The influence of chronic exposure to bisphenol A on cardiac function: a study of ECG parameters in adult female rats Cover

The influence of chronic exposure to bisphenol A on cardiac function: a study of ECG parameters in adult female rats

Romanian Journal of Cardiology
Volume 35 (2025): Issue 3 (September 2025)
By: Vasile-Bogdan Halaţiu,  Dan-Alexandru Cozac,  Ioana Alkora Balan,  Marcel Perian,  Valeriu Revenco,  Vitalie Moscalu and  Alina Scridon  
Open Access
|Sep 2025

Figures & Tables

Figure 1

The ECG parameters measurement.
The ECG parameters measurement.

Figure 2

Schematic representation of the study protocol.
Schematic representation of the study protocol.

Figure 3

Heart rate in control rats and in rats exposed to human relevant (BPA) and supraphysiological (hBPA) bisphenol A doses for 7 consecutive weeks. Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the control and hBPA groups based on the Mann–Whitney test.
Heart rate in control rats and in rats exposed to human relevant (BPA) and supraphysiological (hBPA) bisphenol A doses for 7 consecutive weeks. Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the control and hBPA groups based on the Mann–Whitney test.

Figure 4

ECG parameters in control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 7 weeks. The figure illustrates the duration of the P wave (A) and the QRS complex (B). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.
ECG parameters in control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 7 weeks. The figure illustrates the duration of the P wave (A) and the QRS complex (B). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.

Figure 5

The duration of the PQ segment (ms). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.
The duration of the PQ segment (ms). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.

Figure 6

ECG parameters in control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 7 weeks. The figure illustrates the duration of the ST segment (A) and the T wave (B). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.
ECG parameters in control rats and in rats exposed to usual (BPA) and high (hBPA) bisphenol A doses for 7 weeks. The figure illustrates the duration of the ST segment (A) and the T wave (B). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.

Figure 7

The duration of the QT interval (ms). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.
The duration of the QT interval (ms). Data are expressed as median and interquartile ranges; p-values were calculated using the Kruskal–Wallis and the Mann–Whitney U tests. * The p-value refers to the comparison between groups based on the Kruskal–Wallis test; ** the p-value refers to the comparison between the Control and hBPA groups based on the Mann–Whitney test.
DOI: https://doi.org/10.2478/rjc-2025-0012 | Journal eISSN: 2734-6382 | Journal ISSN: 1220-658X
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Language: English
Page range: 205 - 212
Published on: Sep 30, 2025
Published by: Romanian Society of Cardiology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
arrhythmias,
bisphenol A,
cardiotoxicity,
ECG parameters
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Cardiology,
Surgery,
Cardiac surgery,
Pediatrics and juvenile medicine,
Paediatric cardiology

© 2025 Vasile-Bogdan Halaţiu, Dan-Alexandru Cozac, Ioana Alkora Balan, Marcel Perian, Valeriu Revenco, Vitalie Moscalu, Alina Scridon, published by Romanian Society of Cardiology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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