Abstract
Purpose
This study evaluates the association between serum ferritin levels, coronary artery disease (CAD) severity, and survival outcomes over two years. It also examines correlations between ferritin and clinical parameters, including age and creatinine.
Methods
A total of 300 CAD patients underwent coronary angiography (CAG). Serum ferritin levels were categorized as low (<30 μg/L), normal (30–300 μg/L for males and 30–200 μg/L for females), and high (>300 μg/L for males and >200 μg/L for females). CAD severity was classified into non-critical, single-vessel, dual-vessel, and triple-vessel disease. Survival outcomes were recorded as alive, deceased, or lost to follow-up. Statistical analyses included Pearson’s correlation, Chi-square tests, and Kaplan–Meier survival curves.
Results
The mean age was 59.03 ± 9.42 years, with 71.66% males. Hypertension and diabetes were present in 51.66% and 35.33% of patients, respectively. Ferritin levels showed a weak negative correlation with age (r = -0.122, P = 0.035) and a positive correlation with creatinine (r = 0.281, P = 0.001). Elevated ferritin levels were significantly associated with dual-vessel disease (50%) and mortality (P = 0.001). Deceased patients had higher ferritin levels (142.0 μg/L vs. 90.45 μg/L in survivors; P = 0.001).
Conclusions
Ferritin is strongly associated with CAD severity and mortality, particularly in dual-vessel disease. Its potential role in early risk stratification suggests clinical relevance. Further research should explore ferritin’s mechanistic link to CAD progression and its integration into prognostic models.