Elasticity and Lipids Changes in Children with Type I Diabetes Mellitus Compared with Controls and the Effect of Lipids on Elasticity in Diabetic Children

Noori, Noor Mohammad; Teimouri, Alireza; Moghadam, Maryam Nakhaei

doi:10.2478/rjc-2023-0019

Figures & Tables

Measurements of systolic (S) and diastolic (D) diameters of the ascending aorta are shown on the M mode tracing obtained at a level 3 cm above the aortic valve (4).

Boxplot presentation of heart-stiffening parameters, lipids, Doppler findings, and diameter of aorta in systole and diastole in patients and in controls.

Comparing Doppler tissue imaging, aortic stiffness, and lipid profile levels in children with diabetes and in controls

Variab.	Groups	Mean	SD	Mean rank	Test value	P value	Variab.s	Mean	SD	Mean rank	Test value	P value
Age	Case	10.84	3.43	95.2	4166	0.665	LDL	90.61	23.93	105.82	3179	0.002
Age	Control	10.8	2.85	91.8	4166	0.665	LDL	78.55	21.48	81.18	3179	0.002
Height	Case	136.8	18.9	69.55	2097	<0.001	HDL	54.29	11.86	63.39	1524.5	<0.001
Height	Control	153.7	12.63	117.45	2097	<0.001	HDL	69.71	11.73	123.61	1524.5	<0.001
Weight	Case	32.92	11.81	70.42	2178	0.001	SBP	97.8	10.39	82.14	3268	0.003
Weight	Control	44.38	12.31	116.58	2178	0.001	SBP	101.49	9.8	104.86
EF	Case	75.55	5.93	84.02	3442.5	0.016	DBP	62.04	7.45	78.15	2897	<0.001
EF	Control	77.57	4.93	102.98	3442.5	0.016	DBP	66.46	7.67	108.85	2897	<0.001
FS	Case	43.96	5.4	83.22	-2.58	0.011	AOS	2.27	0.32	114.88	2336.5	<0.001
FS	Control	45.87	4.68	103.78	-2.58	0.011	AOS	2.01	0.31	72.12	2336.5	<0.001
LVM	Case	47.62	20.43	90.42	4038.500	0.436	AOD	1.87	0.29	96.6	4036.5	0.433
LVM	Control	40.24	21.38	96.58	4038.500	0.436	AOD	1.85	0.32	90.4	4036.5	0.433
Left MPI	Case	0.79	0.1	134.06	552	<0.001	ASBI	10.76	15.66	122.99	1582.00	<0.001
Left MPI	Control	0.52	0.13	52.94	552	<0.001	ASBI	2.52	1.13	64.01	1582.00	<0.001
Right MPI	Case	0.76	0.12	121.12	8.01	<0.001	AS	9.35	7.00	59.95	1204.00	<0.001
Right MPI	Control	0.63	0.11	65.88	8.01	<0.001	AS	22.40	11.70	127.05	1204.00	<0.001
TG	Case	124.52	76.17	100.3	3692	0.085	AD	0.005	0.006	64.98	1672.50	<0.001
TG	Control	94.39	30.07	86.7	3692	0.085	AD	0.014	0.008	122.02	1672.50	<0.001
CHO	Case	155.54	37.52	112.67	5.46	<0.001	PSEM	8.80	13.24	125.15	1381.50	<0.001
CHO	Control	125.78	36.83	74.33	5.46	<0.001	PSEM	1.96	0.90	61.85	1381.50	<0.001

Correlation between aortic stiffness parameters and Doppler tissue imaging, as well lipid profiles before and after controlling for age in patients_

Before controlling for age
Variables	Statistics	SBP	DBP	AOS	AOD	AS	AD	ASβl	PSEM
Duration	r	0.073	-0.002	0.085	0.087	-.160-	-.197-	0.223	0.255
Duration	p	0.489	0.984	0.419	0.407	0.126	0.058	0.032	0.014
HbA1c	r	0.274	0.265	-.004-	-.091-	-.008-	0.031	-0.063	-0.058
HbA1c	p	0.008	0.01	0.97	0.384	0.939	0.766	0.548	0.578
EF	r	-0.254	-0.224	-.056-	0.036	0.012	0.051	-.066-	-.110-
EF	p	0.014	0.031	0.597	0.735	0.909	0.625	0.532	0.295
FS	r	-0.241	-0.203	0.01	0.089	0.026	0.062	-.059-	-.098-
FS	p	0.02	0.051	0.924	0.394	0.802	0.557	0.574	0.35
Left MPI	r	0.148	0.186	-.014-	-.050-	0.158	0.177	-.059-	0.003
Left MPI	p	0.156	0.074	0.897	0.635	0.131	0.09	0.576	0.978
Right MPI	r	0.219	0.213	-.057-	-.063-	-.053-	0.015	0.067	0.115
Right MPI	p	0.035	0.04	0.589	0.547	0.616	0.886	0.525	0.273
LVM	r	.055	-.024	.047	.123	-.131	-.142	.108	.106
LVM	p	.454	.748	.524	.093	.076	.053	.142	.151
TG	r	-.025-	-.077-	0.052	0.026	0.097	-.007-	0	-.013-
TG	p	0.809	0.464	0.62	0.801	0.357	0.951	0.998	0.902
CHO	r	-.050-	-.075-	-.080-	-.038-	-.159-	-.151-	0.072	0.112
CHO	p	0.633	0.472	0.444	0.719	0.129	0.148	0.49	0.287
LDL	r	-.092-	-.060-	-.067-	-.030-	-.077-	-.053-	-.007-	-.005-
LDL	p	0.378	0.569	0.523	0.776	0.466	0.612	0.946	0.963
HDL	r	-.067-	-.010-	0.078	0.091	-.107-	-.082-	0.115	0.109
HDL	p	0.523	0.921	0.455	0.384	0.306	0.437	0.272	0.299
After controlling for age
duration	r	0.008	-0.048	-0.011	-0.01	-0.176	-0.221	0.219	0.25
duration	p	0.942	0.649	0.915	0.922	0.094	0.034	0.036	0.016
HbA1c	r	0.294	0.271	-0.018	-0.129	-0.009	0.029	-0.064	-0.059
HbA1c	p	0.004	0.009	0.864	0.22	0.929	0.781	0.545	0.574
EF	r	-0.285	-0.236	-0.076	0.038	0.011	0.051	-0.066	-0.11
EF	p	0.006	0.024	0.469	0.719	0.915	0.632	0.531	0.295
FS	r	-0.284	-0.223	-0.016	0.084	0.023	0.057	-0.061	-0.1
FS	p	0.006	0.033	0.88	0.426	0.826	0.587	0.566	0.341
Left MPI	r	0.209	0.222	0.054	0.01	0.167	0.191	-0.055	0.008
Left MPI	p	0.046	0.033	0.607	0.925	0.111	0.068	0.602	0.938
Right MPI	r	0.238	0.219	-0.078	-0.087	-0.054	0.014	0.066	0.115
Right MPI	p	0.022	0.036	0.461	0.411	0.612	0.894	0.53	0.277
LVM	r	.047	-.029	.035	.127	-.130	-.139	.111	.108
LVM	p	.528	.691	.640	.084	.078	.059	.133	.145
TG	r	-0.051	-0.094	0.028	-0.005	0.093	-0.013	-0.002	-0.016
TG	p	0.629	0.37	0.789	0.966	0.379	0.903	0.986	0.882
CHO	r	-0.012	-0.052	-0.031	0.024	-0.152	-0.141	0.077	0.117
CHO	p	0.909	0.624	0.771	0.82	0.148	0.179	0.467	0.265
LDL	r	-0.019	-0.01	0.052	0.102	-0.063	-0.031	0.001	0.005
LDL	p	0.861	0.924	0.621	0.331	0.553	0.767	0.996	0.96
HDL	r	-0.187	-0.081	-0.078	-0.065	-0.131	-0.115	0.108	0.099
HDL	p	0.074	0.445	0.457	0.537	0.214	0.276	0.304	0.349

Elasticity and Lipids Changes in Children with Type I Diabetes Mellitus Compared with Controls and the Effect of Lipids on Elasticity in Diabetic Children

Figures & Tables

Figure 1

Figure 2

Comparing Doppler tissue imaging, aortic stiffness, and lipid profile levels in children with diabetes and in controls

Correlation between aortic stiffness parameters and Doppler tissue imaging, as well lipid profiles before and after controlling for age in patients_

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