Stem Cell Therapy in Myocardial Infarction: Still Therapeutic Hope?

Oancea, Alexandru Florinel; Chipăilă, Elena Diana; Iov, Elena Diana; Morariu, Paula; Tănase, Daniela Maria; Floria, Mariana

doi:10.2478/rjc-2022-0027

Abstract

Myocardial infarction is still a therapeutic rollercoaster challenge because, despite revolutionary treatments in its management, heart failure is still a consequence. Stem cell therapy might be a turning point in treating myocardial infarction patients for regaining what is lost—that is, myocardial tissue. This paper reviews the latest evidence for using stem cell therapy in the treatment of myocardial infarction, the results of this possible therapy regarding regaining cardiomyocytes, and the extent to which therapy with stem cells can be used in the future for the management of acute coronary syndromes.

References

Madonna, R. Stem cells and cardiac regeneration. Springer International: New York. 2016.
Search in Google Scholar Back to article
Barzegar M, Kaur G, Gavins FNE, Wang Y, Boyer CJ, Alexander JS. Potential therapeutic roles of stem cells in ischemia-reperfusion injury. Stem Cell Res 2019; 37: 101421.
Search in Google Scholar Back to article
Hao L, Zou Z, Tian H, Zhang Y, Zhou H, Liu L. Stem cell-based therapies for ischemic stroke. Biomed Res Int 2014; 2014: 2–15.
Search in Google Scholar Back to article
Sukhikh GT, Malaitsev VV, Bogdanova IM. Application potential of human fetal stem/progenitor cells in cell therapy. Bull Exp Biol Med 2008; 145(1): 114–121.
Search in Google Scholar Back to article
Abbaspanah B, Momeni M, Ebrahimi M, Mousavi SH. Advances in perinatal stem cell research: a precious cell source for clinical applications. Regen Med 2018; 13(5): 595–610.
Search in Google Scholar Back to article
Kalra K, Tomar PC. Stem cell: basics, classification and applications. Am J Phytomed Clin Therapeut 2014; 2(7): 919–930.
Search in Google Scholar Back to article
Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration. 2013; 85(1): 3–10.
Search in Google Scholar Back to article
Li C, Chen S, Zhou Y, Zhao Y, Liu P, Cai J. Application of induced pluripotent stem cell transplants: Autologous or allogeneic? Life Sci 2018; 212: 145–149.
Search in Google Scholar Back to article
Thanasegaran S, Cheng Z, Ito S, Nishio N, Isobe K. No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments. Biomed Res Int 2013; 2013: 378207.
Search in Google Scholar Back to article
Zhang Y, Mignone J, MacLellan WR. Cardiac regeneration and stem cells. Physiol Rev 2015; 95(4): 1189–1204.
Search in Google Scholar Back to article
Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004; 95(9): 911–921.
Search in Google Scholar Back to article
Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, et al. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci USA 2013; 110(4): 1446–1451.
Search in Google Scholar Back to article
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, et al. Evidence for cardiomyocyte renewal in humans. Science 2009; 324(5923): 98–102.
Search in Google Scholar Back to article
Kim SH, Cho JH, Lee YH, Lee JH, Kim SS, Kim MY, et al. Improvement in left ventricular function with intracoronary mesenchymal stem cell therapy in a patient with anterior wall ST-segment elevation myocardial infarction. Cardiovasc Drugs Ther 2018; 32(4): 329–338.
Search in Google Scholar Back to article
Zhang R, Yu J, Zhang N, Li W, Wang J, Cai G, et al. Bone marrow mesenchymal stem cells transfer in patients with ST-segment elevation myocardial infarction: single-blind, multicenter, randomized controlled trial. Stem Cell Res Ther 2021; 12(1): 33.
Search in Google Scholar Back to article
Peregud-Pogorzelska M, Przybycień K, Baumert B, Kotowski M, Pius-Sadowska E, Safranow K, et al. The effect of intracoronary infusion of autologous bone marrow-derived lineage-negative stem/progenitor cells on remodeling of post-infarcted heart in patient with acute myocardial infarction. Int J Med Sci 2020; 17(8): 985–994.
Search in Google Scholar Back to article
Nicolau JC, Furtado RHM, Silva SA, Rochitte CE, Rassi A, Moraes JBMC, et al.; MiHeart/AMI Investigators. Stem-cell therapy in ST-segment elevation myocardial infarction with reduced ejection fraction: A multicenter, double-blind randomized trial. Clin Cardiol 2018; 41(3): 392–399.
Search in Google Scholar Back to article
Gastl M, Sürder D, Corti R, Faruque Osmany DMM, Gotschy A, von Spizcak J, et al. Effect of intracoronary bone marrow-derived mononuclear cell injection early and late after myocardial infarction on CMR-derived myocardial strain. Int J Cardiol 2020; 310: 108–115.
Search in Google Scholar Back to article
Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, Casado Plasencia A, Gilaberte I, Belmans A, et al. Safety and efficacy of intracoronary infusion of allogeneic human cardiac stem cells in patients with ST-segment elevation myocardial infarction and left ventricular dysfunction. Circ Res 2018; 123(5): 579–589.
Search in Google Scholar Back to article
Makkar RR, Kereiakes DJ, Aguirre F, Kowalchuk G, Chakravarty T, Malliaras K, et al. Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial. Eur Heart J 2020; 41(36): 3451–3458.
Search in Google Scholar Back to article
Ong SB, Hernández-Reséndiz S, Crespo-Avilan GE, Mukhametshina RT, Kwek XY, Cabrera-Fuentes HA, et al. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacol Ther 2018; 186: 73–87.
Search in Google Scholar Back to article
Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106(15): 1913–1918.
Search in Google Scholar Back to article
Florea V, Rieger AC, DiFede DL, El-Khorazaty J, Natsumeda M, Banerjee MN, et al. Dose comparison study of allogeneic mesenchymal stem cells in patients with ischemic cardiomyopathy (The TRIDENT Study). Circ Res 2017; 121(11): 1279–1290.
Search in Google Scholar Back to article
Parizadeh SM, Jafarzadeh-Esfehani R, Ghandehari M, Parizadeh MR, Ferns GA, Avan A, et al. Stem cell therapy: A novel approach for myocardial infarction. J Cell Physiol 2019; 234(10): 16904–16912.
Search in Google Scholar Back to article
Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004; 364(9429): 141–148.
Search in Google Scholar Back to article
Thakker R, Yang P. Mesenchymal stem cell therapy for cardiac repair. Curr Treat Options Cardiovasc Med 2014; 16(7): 323–331.
Search in Google Scholar Back to article
Marino L, Castaldi MA, Rosamilio R, Ragni E, Vitolo R, Fulgione C, et al. Mesenchymal stem cells from the Wharton's Jelly of the human umbilical cord: biological properties and therapeutic potential. Int J Stem Cells 2019; 12(2): 218–226.
Search in Google Scholar Back to article
Fukushima S, Sawa Y, Suzuki K. Choice of cell-delivery route for successful cell transplantation therapy for the heart. Future Cardiol 2013; 9(2): 215–227.
Search in Google Scholar Back to article
Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, et al. Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. PLoS One 2011; 6(9): e24164.
Search in Google Scholar Back to article
Clifford DM, Fisher SA, Brunskill SJ, Doree C, Mathur A, Clarke MJ, et al. Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes. PLoS One 2012; 7(5): e37373.
Search in Google Scholar Back to article
Tseliou E, Pollan S, Malliaras K, Terrovitis J, Sun B, Galang G, et al. Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains. J Am Coll Cardiol 2013; 61(10): 1108–1119.
Search in Google Scholar Back to article
Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol 2012; 59(10): 942–953.
Search in Google Scholar Back to article

Stem Cell Therapy in Myocardial Infarction: Still Therapeutic Hope?

Abstract

Paradigm

My account