Skip to main content
Have a personal or library account? Click to login
Clinical impact of structured weight reduction on muscle mass in COPD with sarcopenic obesity Cover

Clinical impact of structured weight reduction on muscle mass in COPD with sarcopenic obesity

Open Access
|Jul 2026

References

  1. Global Initiative for Chronic Obstructive Lung Disease. (2023): Global strategy for prevention, diagnosis and management of COPD report. Available from: http://www.goldcopd.org.
  2. Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, et al. Obesity is associated with increased morbidity in moderate to severe COPD. Chest. 2017;151(1): 68–77. doi:10.1016/j.chest.2016.08.1432
  3. Piché ME, Tchernof A, Després JP. Obesity phenotypes, diabetes, and cardio vascular diseases. Circulation Research. 2020; 126(11): 1477–1500. doi:10.1161/CIRCRESAHA.120.316101
  4. Rodríguez DA, Garcia-Aymerich J, Valera JL, Sauleda J, Togores B, Galdiz JB, et al. Determinants of exercise capacity in obese and non-obese COPD patients. Respiratory Medicine. 2014;108(5): 745–751. doi:10.1016/j.rmed.2014.02.004
  5. Franssen FME, O’Donnel DE, Gossens GH, Blaak EE, Schols AMWJ. Obesity and the lungs: 5.Obesity and COPD. Thorax. (2008);63(12): 1110–1117.
  6. Cappellari GG, Guillet C, Poggiogalle E, Pomar MDB, Batsis JA, Boirie Y, et al. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) - Proceedings from the SOGLI consortium meeting in Rome November 2022. Clinical Nutrition. 2023;42(5): 687–699. doi:10.1016/j.clnu.2023.02.018
  7. Li CW, Yu K, Shyh-Chang N, Li GX, Jiang LJ, Yu SL, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. Journal of Cachexia, Sarcopenia and Muscle. 2019;10(3): 586–600. doi:10.1002/jcsm.12417
  8. Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The obesity transition: stages of the global epidemic. Lancet Diabetes and Endocrinology. 2019;7(3): 231240. doi:10.1016/S2213-8587(19)30026-9
  9. Tallis J, James RS, Seebacher F. The effects of obesity on skeletal muscle contractile function. The Journal of Experimental Biology. 2018;221(Pt 13): jeb163840. doi:10.1242/jeb.163840
  10. Wang Z, Zhou X, Deng M, Yin Y, Li Y, Zhang Q, et al. Clinical impacts of sarcopenic obesity on chronic obstructive pulmonary disease: a cross-sectional study. BMC Pulmonary Medicine. 2023;23(1): 394. doi:10.1186/s12890-023-02702-2
  11. Gao J, Deng M, Li Y, Yin Y, Zhou X, Zhang Q, et al. Resistin as a systemic inflammation-related biomarker for sarcopenia in patients with Chronic Obstructive Pulmonary Disease. Frontiers in Nutrition. 2022;9: 921399. doi:10.3389/fnut.2022.921399
  12. Che K, Qiu J, Yi L, Zou M, Li Z, Carr A, et al. Effects of a short-term “fat adaptation with carbohydrate restoration” diet on metabolic responses and exercise performance in well-trained runners. Nutrients. 2021;13(3): 1033. doi:10.3390/nu13031033
  13. Ismail SM, Ahmed MM, Mohamed AH, Shendy EK. Impact of aerobic exercise and diet-induced weight reduction on liver enzymes among centrally obese Egyptian women. World Applied Sciences Journal. 2016;34(1): 35–42. doi: 10.1152/jappl.2000.89.2.465
  14. Janssen I, Heymsfeild SB, Baumgarner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. Journal of Applied Physiology. 2000;899(2): 465–471. doi:10.1152/jappl.2000.89.2.465
  15. Savas S, Kilavuz A, Kahyan FO, Cavdar S. Comparisone of grip strength measurements by widely used three dynamometers in outpatient aged 60 years and over. Journal of Clinical Medicine. 2023;12(13): 4260. doi:10.3390/jcm12134260
  16. Kammin EJ. The 6-minute walk test: indication and guidelines for use in outpatient practices. The Journal for Nurse Practitioners. 2022;18(6): 608–610. doi:10.1016/j.nurpra.2022.04.013
  17. Park JH, Lee JK, Heo EY, Kim DK, Chung HS. The effect of obesity on patients with mild Chronic Obstructive Pulmonary Disease: results from KNHANES 2010 to 2012. International Journal of Chronic Obstructive Pulmonary Disease. 2017;12: 757–763. doi:10.2147/COPD.S126192
  18. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. American Journal of Respiratory and Critical Care Medicine. 2017;195(5): 557–582. doi:10.1164/rccm.201701-0218PP
  19. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guide Lines and The Obesity Society. Journal of the American College of Cardiology. 2013;63(25 Pt B): 2985–3023. doi:10.1016/j.jacc.2013.11.004
  20. Villareal D, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, et al. Weight loss, exercise, or both and physical function in obese older adults. The New England Journal of Medicine. 2011;364(13): 1218–1229. doi:10.1056/NEJMoa1008234
  21. Trouwborst I, Verreijen A, Memelink R, Massanet P, Boirie Y, Weijs P, et al. Exercise and nutrition strategies to counteract sarcopenic obesity. Nutrients. 2018;10(5): 605. doi:10.3390/nu10050605
  22. Rochester CL, Alison JA, Carlin B, Jenkins AR, Cox NS, Bauldoff G, et al. Pulmonary rehabilitation for adults with chronic respiratory disease: an official American thoracic society clinical practice guideline. American Journal of Respiratory and Critical Care Medicine. 2023;208(4): e7-e26. doi:10.1164/rccm.202306-1066ST
  23. Troosters T, Janssens W, Demeyer H, Rabinovich RA. Pulmonary rehabilitation and physical interventions. European Respiratory Review. 2023;32(168): 220222. doi:10.1183/16000617.0222-2022
  24. Marillier M, Bernard AC, Vergés S, Neder JA. Locomotor muscles in COPD: the rationale for rehabilitative exercise training. Frontiers in Physiology. 2020;10: 1590. doi:10.3389/fphys.2019.01590
  25. Jones SE, Maddocks M, Kon SS, Canavan JL, Nolan CM, Clark AL, et al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015;70(3): 213–218. doi:10.1136/thoraxjnl-2014-206440
  26. Sepúlveda-Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. Journal of Cachexia, Sarcopenia and Muscle. 2020;11(5): 11641176. doi:10.1002/jcsm.12600
  27. Benz E, Trajanoska K, Lahousse L, Schoufour JD, Terzikhan N, De Roos E, et al. Sarcopenia in COPD: a systematic review and meta-analysis. European Respiratory Review. 2019;28(154): 190049. doi:10.1183/16000617.0049
  28. Menon MK, Houchen L, Harrison S, Singh SJ, Morgan MD, Steiner MC. Ultrasound assessment of lower limb muscle mass in response to resistance training in COPD. Respiratory Research. 2012;13(1): 119. doi:10.1186/1465-9921-13-119
  29. Eglseer D, Traxler M, Schoufour JD, Weijs PJM, Voortman T, Boirie Y, et al. Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis. Nutrition Reviews. 2023;81(9): 10771090. doi:10.1093/nutrit/nuad007
  30. Janani S, Sedhunivas R. Effectiveness of exercise interventions on muscle mass among older adults with sarcopenic obesity: a scoping review. Aging Medicine. 2024;7(1): 115–120. doi:10.1002/agm2.1228
  31. Hansen EM, McCartney CN, Sweeney RS, Palimenio MR, Grindstaff TL. Hand-held dynamometer positioning impacts discomfort during quadriceps strength testing: a validity and reliability study. International Journal of Sports Physical Therapy. 2015;10(1): 62–68. doi: 10.1159/000501203
  32. Labott BK, Bucht H, Morat M, Morat T, Donath L. Effects of exercise training on handgrip strength in older Adults: a meta-analytical review. Gerontology. 2019;65(6): 686–698. doi:10.1159/000501203
  33. Lee J. Associations of relative handgrip strength and aerobic and strength exercises with metabolic syndrome prevalence. International Journal of Environmental Research and Public Health. 2022;19(22): 14646. doi:10.3390/ijerph192214646
  34. Seong JY, Ahn HY, Park Y, Shin S, Ha I-H. Association between aerobic exercise and handgrip strength in adults: a cross-sectional study based on data from the Korean National Health and Nutrition Examination survey (2014–2017). The Journal of Nutrition, Health & Aging. 2020;24(6): 619–626. doi:10.1007/s12603-020-1372-x
  35. Sarsan A, Ardiç F, Ozgen M, Topuz O, Sermez Y. The effects of aerobic and resistance exercises in obese women. Clinical Rehabilitation. 2006;20(9): 773–782. doi:10.1177/0269215506070795
  36. Vozoris NT, O’Donnell DE. Prevalence, risk factors, activity limitation and health care utilization of an obese, population-based sample with chronic obstructive pulmonary disease. Canadian Respiratory Journal. 2012;19(3): e18–24. doi:10.1155/2012/732618
  37. Joppa P, Tkacova R, Franssen FM, Hanson C, Rennard SI, Silverman EK. Sarcopenic obesity, functional outcomes, and systemic inflammation in patients with chronic obstructive pulmonary disease. Journal of the American Medical Directors Association. 2016;17(8): 712–718. doi:10.1016/j.jamda.2016.03.020
  38. Papadopoulou O, Desli E, Chrysochoou EA, Kogias C, Liakos V, Sopiadou A, et al. Effect of an exercise intervention program on BMI and distance covered in the 6 min walking test (6MWT) in obese children. Children (Basel). 2024;11(12): 1473. doi:10.3390/children11121473
DOI: https://doi.org/10.2478/pneum-2026-0010 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993
Language: English, Romanian
Page range: 68 - 76
Published on: Jul 22, 2026
Published by: Romanian Society of Pneumology
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2026 Alaa Magdy Mostafa, Karim Ahmed, Mahmoud Mohamed El batanouny, Lamis Ahmed Osama Ghaly, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.