Mortality-associated prognostic factors, survival rates, lung functions and complications in post-transplant chronic obstructive pulmonary disease patients: A systematic review and meta-analysis

Hana Khairina Putri Faisal; Ahmad Fadhil Ilham; Hanna Lianti Afladhia; Agus Dwi Susanto; Prasenohadi; Mia Elhidsi; Susan Hendriarini Mety; Faisal Yunus

doi:10.2478/pneum-2026-0007

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Mortality-associated prognostic factors, survival rates, lung functions and complications in post-transplant chronic obstructive pulmonary disease patients: A systematic review and meta-analysis

Pneumologia

Volume 75 (2026): Issue 1 (January 2026)

By: Hana Khairina Putri Faisal, Ahmad Fadhil Ilham, Hanna Lianti Afladhia, Agus Dwi Susanto, Prasenohadi, Mia Elhidsi, Susan Hendriarini Mety and Faisal Yunus

Open Access

|May 2026

Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the prevention, diagnosis, and management of COPD: 2024 Report [Internet]. GOLD; 2024. Available from: https://goldcopd.org/2024-gold-report
Search in Google Scholar Back to article
Adeloye D, Chua S, Lee C, Basquill C, Papana A, Theodoratou E, et al. Global and regional estimates of COPD prevalence: systematic review and meta-analysis. Journal of Global Health. 2015;5(2): 020415. doi:10.7189/jogh.05.020415
Open DOI Search in Google Scholar Back to article
Chen CZ, Shih CY, Hsiue TR, Tsai SH, Liao XM, Yu CH, et al. Life expectancy (LE) and loss-of-LE for patients with chronic obstructive pulmonary disease. Respiratory Medicine. 2020;172: 106132. doi:10.1016/j.rmed.2020.106132
Open DOI Search in Google Scholar Back to article
Chambers DC, Cherikh WS, Goldfarb SB, Hayes D Jr, Kucheryavaya AY, Toll AE, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult lung and heart-lung transplant report-2018; focus theme: Multiorgan Transplantation. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation. 2018;37(10): 1169–1183. doi:10.1016/j.healun.2018.07.020
Open DOI Search in Google Scholar Back to article
Verleden GM, Gottlieb J. Lung transplantation for COPD/pulmonary emphysema. European Respiratory Review. 2023;32(167): 220116. doi:10.1183/16000617.0116-2022
Open DOI Search in Google Scholar Back to article
Leard LE, Holm AM, Valapour M, Glanville AR, Attawar S, Aversa M, et al. Consensus document for the selection of lung transplant candidates: an update from the International Society for Heart and Lung Transplantation. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation. 2021;40(11): 1349–1379. doi:10.1016/j.healun.2021.07.005
Open DOI Search in Google Scholar Back to article
Son J, Shin C. Indications for lung transplantation and patient selection. Journal of Chest Surgery. 2022;55(4): 255–264. doi:10.5090/jcs.22.057
Open DOI Search in Google Scholar Back to article
Raskin J, Vanstapel A, Verbeken EK, Beeckmans H, Vanaudenaerde BM, Verleden SE, et al. Mortality after lung transplantation: a single-centre cohort analysis. Transplant International : Official journal of the European Society for Organ Transplantation. 2020;33(2): 130–141. doi:10.1111/tri.13540
Open DOI Search in Google Scholar Back to article
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. The BMJ. 2021;372: n71. doi:10.1136/bmj.n71
Open DOI Search in Google Scholar Back to article
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Systematic Reviews. 2016;5(1): 210. doi:10.1186/s13643-016-0384-4
Open DOI Search in Google Scholar Back to article
Schwarzer G. Meta-analysis in R. 1st ed. In: Egger M, Higgins JPT, Davey Smith G (eds.) Systematic reviews in health research [Internet]. Wiley; Hoboken, New Jersey. 2022. p. 510–534.
Search in Google Scholar Back to article
Takeshima N, Sozu T, Tajika A, Ogawa Y, Hayasaka Y, Furukawa TA. Which is more generalizable, powerful and interpretable in meta-analyses, mean difference or standardized mean difference? BMC Medical Research Methodology. 2014;14: 30. doi:10.1186/1471-2288-14-30
Open DOI Search in Google Scholar Back to article
Cerón Navarro J, de Aguiar-Quevedo K, Mancheño Franch N, Peñalver Cuesta JC, Vera Sempere FJ, Padilla J. Complicaciones del trasplante de pulmón en la enfermedad pulmonar obstructiva crónica. Medicina Clínica. 2013;140(9): 385–389. doi:10.1016/j.medcli.2012.07.028
Open DOI Search in Google Scholar Back to article
Cerón Navarro J, de Aguiar Quevedo K, Ansótegui Barrera E, Jordá Aragón C, Peñalver Cuesta JC, Mancheño Franch N, et al. Functional outcomes after lung transplant in chronic obstructive pulmonary disease. Archivos de Bronconeumologia. 2015;51(3): 109–114. doi:10.1016/j.arbres.2014.06.012
Open DOI Search in Google Scholar Back to article
Latos M, Nęcki M, Pawlak D, Urlik M, Antończyk R, Ochman M, et al. Outcome of lung transplantation as a treatment of patients with chronic obstructive pulmonary disease: a single-center study. Transplantation Proceedings. 2020;52(7): 2118–2122. doi:10.1016/j.transproceed.2020.02.107
Open DOI Search in Google Scholar Back to article
Türkkan S, Çelik Başaran F, Şahin MF, Beyoğlu MA, Bindal M, Yazıcıoğlu A, et al. Outcomes of lung transplantation for chronic obstructive pulmonary disease. Tuberk Ve Toraks. 2023;71(3): 215–223. doi:10.5578/tt.20239703
Open DOI Search in Google Scholar Back to article
de Pablo A, Morales P, Román A, Lama R, García-López F, Borro JM, et al. EPOC y trasplante pulmonar: resultados en España. Archivos de Bronconeumologia. 1999;35(7): 334–338. doi:10.1016/S0300-2896(15)30071-5
Open DOI Search in Google Scholar Back to article
Bennett DT, Zamora M, Reece TB, Mitchell JD, Cleveland JC Jr, Grover FL, et al. Continued utility of single-lung transplantation in select populations: chronic obstructive pulmonary disease. The Annals of Thoracic Surgery. 2015;100(2): 437–442. doi:10.1016/j.athoracsur.2015.03.024
Open DOI Search in Google Scholar Back to article
Cano JR, Algar FJ, Cerezo F, Moreno P, Espinosa D, Alvarez A, et al. Results of lung transplantation in patients with chronic obstructive pulmonary disease. Transplantation Proceedings. 2008;40(9): 3073–3075. doi:10.1016/j.transproceed.2008.09.004
Open DOI Search in Google Scholar Back to article
Crawford TC, Lui C, Magruder JT, Ha JS, Higgins RS, Merlo CA, et al. Five-year mortality hazard is reduced in chronic obstructive pulmonary disease patients receiving double-versus single-lung transplants. The Journal of Surgical Research. 2019;237: 118–125. doi:10.1016/j.jss.2018.04.048
Open DOI Search in Google Scholar Back to article
de Miguel-Díez J, López-de-Andres A, Hernández-Barrera V, de Miguel-Yanes JM, Méndez-Bailón M, Jiménez-García R. Trends and hospital outcomes of lung transplantation among patients with and without chronic obstructive pulmonary disease in Spain: a national population-based study (2001-2015). International Journal of Chronic Obstructive Pulmonary Disease. 2019;14: 729–737. doi:10.2147/COPD.S189010
Open DOI Search in Google Scholar Back to article
De Miguel-Diez J, Jimenez-Garcia R, Hernández-Barrera V, Carabantes-Alarcon D, Zamorano-Leon JJ, Cuadrado-Corrales N, et al. Time trends in clinical characteristics and hospital outcomes of hospitalizations for lung transplantation in COPD patients in Spain from 2016 to 2020-impact of the COVID-19 pandemic. Journal of Clinical Medicine. 2023;12(3): 963. doi:10.3390/jcm12030963
Open DOI Search in Google Scholar Back to article
Duffy JS, Tumin D, Pope-Harman A, Whitson BA, Higgins RSD, Hayes D. Induction therapy for lung transplantation in COPD: analysis of the UNOS registry. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2016;13(5): 647–652. doi:10.3109/15412555.2015.1127340
Open DOI Search in Google Scholar Back to article
Gaissert HA, Trulock EP, Cooper JD, Sundaresan RS, Patterson GA. Comparison of early functional results after volume reduction or lung transplantation for chronic obstructive pulmonary disease. The Journal of Thoracic and Cardiovascular Surgery. 1996;111(2): 296–307. doi:10.1016/S0022-5223(96)70438-5
Open DOI Search in Google Scholar Back to article
Güneş A, Aboyoun CL, Morton JM, Plit M, Malouf MA, Glanville AR. Lung transplantation for chronic obstructive pulmonary disease at St Vincent’s Hospital. Internal Medicine Journal. 2006;36(1): 5–11. doi:10.1111/j.1445-5994.2006.01003.x
Open DOI Search in Google Scholar Back to article
Hadjiliadis D, Chaparro C, Gutierrez C, Steele MP, Singer LG, Davis RD, et al. Impact of lung transplant operation on bronchiolitis obliterans syndrome in patients with chronic obstructive pulmonary disease. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2006;6(1): 183–189. doi:10.1111/j.1600-6143.2005.01159.x
Open DOI Search in Google Scholar Back to article
Hayes D, Tumin D, Budev MM, Tobias JD, St John RC, Kukreja J. Adverse outcomes associated with pulmonary hypertension in chronic obstructive pulmonary disease after bilateral lung transplantation. Respiratory Medicine. 2017;128: 102–108. doi:10.1016/j.rmed.2017.04.010
Open DOI Search in Google Scholar Back to article
Lahzami S, Bridevaux PO, Soccal PM, Wellinger J, Robert JH, Ris HB, et al. Survival impact of lung transplantation for COPD. European Respiratory Journal. 2010;36(1): 74–80. doi:10.1183/09031936.00087809
Open DOI Search in Google Scholar Back to article
Mutyala S, Kashem MA, Kanaparthi J, Sunagawa G, Suryapalam M, Leotta E, et al. Comparing outcomes in patients with end-stage chronic obstructive pulmonary disease: single versus bilateral lung transplants. Interactive Cardiovascular and Thoracic Surgery. 2021;33(5): 807–813. doi:10.1093/icvts/ivab169
Open DOI Search in Google Scholar Back to article
Nunley DR, Bauldoff GS, Holloman CH, Pope-Harman A. The lung allocation score and survival in lung transplant candidates with chronic obstructive pulmonary disease. Lung. 2009;187(6): 383–387. doi:10.1007/s00408-009-9180-4
Open DOI Search in Google Scholar Back to article
Singh VK, Patricia George M, Gries CJ. Pulmonary hypertension is associated with increased post-lung transplant mortality risk in patients with chronic obstructive pulmonary disease. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation. 2015;34(3): 424–429. doi:10.1016/j.healun.2015.01.002
Open DOI Search in Google Scholar Back to article
Stavem K, Bjørtuft Ø, Borgan Ø, Geiran O, Boe J. Lung transplantation in patients with chronic obstructive pulmonary disease in a national cohort is without obvious survival benefit. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation. 2006;25(1): 75–84. doi:10.1016/j.healun.2005.06.025
Open DOI Search in Google Scholar Back to article
Tanash HA, Riise GC, Ekström MP, Hansson L, Piitulainen E. Survival benefit of lung transplantation for chronic obstructive pulmonary disease in Sweden. The Annals of Thoracic Surgery. 2014;98(6): 1930–1935. doi:10.1016/j.athoracsur.2014.07.030
Open DOI Search in Google Scholar Back to article
Thabut G, Ravaud P, Christie JD, Castier Y, Fournier M, Mal H, et al. Determinants of the survival benefit of lung transplantation in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2008;177(10): 1156–1163. doi:10.1164/rccm.200708-1283OC
Open DOI Search in Google Scholar Back to article
Zeriouh M, Mohite PN, Sabashnikov A, Zych B, Patil NP, Garcia-Saez D, et al. Lung transplantation in chronic obstructive pulmonary disease: long-term survival, freedom from bronchiolitis obliterans syndrome, and factors influencing outcome. Clinical Transplantation. 2015;29(4): 383–392. doi:10.1111/ctr.12528
Open DOI Search in Google Scholar Back to article
Siddiqui FM, Diamond JM. Lung Transplantation for chronic obstructive pulmonary disease: past, present, and future directions. Current Opinion in Pulmonary Medicine. 2018;24(2): 199–204. doi:10.1097/MCP.0000000000000452
Open DOI Search in Google Scholar Back to article
Girgis RE, Khaghani A. A global perspective of lung transplantation: part 1 - Recipient selection and choice of procedure. Global cardiology science & practice. 2016;2016(1): e201605. doi:10.21542/gcsp.2016.5
Open DOI Search in Google Scholar Back to article
Eng NAM, Arjunan V, Prabhakar V, Mannalithara A, Ghaziani T, Ahmed A, et al. Post-transplant outcomes in older patients with Hepatocellular Carcinoma (HCC) are driven by non-HCC factors. Liver Transplantation. 2021;27(5): 684–698. doi:10.1002/lt.25974
Open DOI Search in Google Scholar Back to article
Trinkmann F, Saur J, Borggrefe M, Akin I. Cardiovascular comorbidities in Chronic Obstructive Pulmonary Disease (COPD)— current considerations for clinical practice. Journal of Clinical Medicine. 2019;8(1): 69. doi:10.3390/jcm8010069
Open DOI Search in Google Scholar Back to article
Hackman KL, Bailey MJ, Snell GI, Bach LA. Diabetes is a major risk factor for mortality after lung transplantation. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2014;14(2): 438–445. doi:10.1111/ajt.12561
Open DOI Search in Google Scholar Back to article
Klein OL, Krishnan JA, Glick S, Smith LJ. Systematic review of the association between lung function and type 2 diabetes mellitus. Diabetic Medicine: A Journal of the British Diabetic Association. 2010;27(9): 977–987. doi:10.1111/j.1464-5491.2010.03073.x
Open DOI Search in Google Scholar Back to article
Lu Y, Wang W, Liu J, Xie M, Liu Q, Li S. Vascular complications of diabetes: a narrative review. Medicine (Baltimore). 2023;102(40): e35285. doi:10.1097/MD.0000000000035285
Open DOI Search in Google Scholar Back to article
Russo MJ, Davies RR, Hong KN, Iribarne A, Kawut S, Bacchetta M, et al. Who is the high-risk recipient? Predicting mortality after lung transplantation using pretransplant risk factors. The Journal of Thoracic and Cardiovascular Surgery. 2009;138(5): 1234–1238. doi:10.1016/j.jtcvs.2009.07.036
Open DOI Search in Google Scholar Back to article
Braun L. Race, ethnicity and lung function: A brief history. Canadian Journal of Respiratory Therapy. 2015;51(4):99–101. PMID: 26566381.
Search in Google Scholar Back to article
Braun L, Wolfgang M, Dickersin K. Defining race/ethnicity and explaining difference in research studies on lung function. European Respiratory Journal. 2013;41(6): 1362–1370. doi:10.1183/09031936.00091612
Open DOI Search in Google Scholar Back to article
Fang YC, Cheng WH, Lu HI, Wang YS, Chuang KH, Lai HH, et al. Double lung transplantation is better than single lung transplantation for end-stage chronic obstructive pulmonary disease: a meta-analysis. Journal of Cardiothoracic Surgery. 2024;19: 162. doi:10.1186/s13019-024-02654-6
Open DOI Search in Google Scholar Back to article
Yu H, Bian T, Yu Z, Wei Y, Xu J, Zhu J, et al. Bilateral lung transplantation provides better long-term survival and pulmonary function than single lung transplantation: a systematic review and meta-analysis. Transplantation. 2019;103(12): 2634–2644. doi:10.1097/TP.0000000000002841
Open DOI Search in Google Scholar Back to article
Todd JL, Palmer SM. Lung transplantation in advanced copd: is it worth it? Seminars in Respiratory and Critical Care Medicine. 2010;31(3): 365–372. doi:10.1055/s-0030-1254076
Open DOI Search in Google Scholar Back to article
Munson JC, Christie JD, Halpern SD. The societal impact of single versus bilateral lung transplantation for chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2011;184(11): 1282–1288. doi:10.1164/rccm.201104-0695OC
Open DOI Search in Google Scholar Back to article
Santambrogio L, Tarsia P, Mendogni P, Tosi D. Transplant options for end stage chronic obstructive pulmonary disease in the context of multidisciplinary treatments. Journal of Thoracic Disease. 2018;10(Suppl 27): S3356–65. doi:10.21037/jtd.2018.04.166
Open DOI Search in Google Scholar Back to article
Csoma B, Vulpi MR, Dragonieri S, Bentley A, Felton T, Lázár Z, et al. Hypercapnia in COPD: causes, consequences, and therapy. Journal of Clinical Medicine. 2022;11(11): 3180. doi:10.3390/jcm11113180
Open DOI Search in Google Scholar Back to article
Lius EE, Syafaah I. Hyperoxia in the management of respiratory failure: a literature review. Annals of Medicine and Surgery. 2022;81: 104393. doi:10.1016/j.amsu.2022.104393
Open DOI Search in Google Scholar Back to article
Lagina M, Valley TS. Diagnosis and management of acute respiratory failure. Critical Care Clinics. 2024;40(2): 235–253. doi:10.1016/j.ccc.2024.01.002
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.2478/pneum-2026-0007 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993

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Language: English

Page range: 44 - 57

Published on: May 11, 2026

Published by: Romanian Society of Pneumology

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

Chronic obstructive pulmonary disease,

lung transplantation,

Related subjects:

Clinical medicine, other,

Internal medicine,

Pneumology

© 2026 Hana Khairina Putri Faisal, Ahmad Fadhil Ilham, Hanna Lianti Afladhia, Agus Dwi Susanto, Prasenohadi, Mia Elhidsi, Susan Hendriarini Mety, Faisal Yunus, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 75 (2026): Issue 1 (January 2026)