Abstract
Pulmonary thromboembolism (PE) is a medical emergency, and its diagnosis is often challenging due to non-specific symptoms. Combined oral contraceptives (COCs) are a risk factor for PE, especially in association with underlying coagulopathies. In this context, we present several clinical cases of patients with a history of COC use for 5–6 months who presented to the emergency room of our institute with non-specific symptoms. Following specialist consultation and appropriate diagnostic testing (D-dimers, contrast-enhanced chest computed tomography [CT]), all these patients were diagnosed with PE. Haematological tests recommended after discharge revealed various forms of thrombophilia, highlighting the importance of a rigorous evaluation before initiating hormonal therapy.