Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Fouad A. Abolaban; Essam M. Banoqitah; Eslam M. Taha; Abdulsalam M. Alhawsawi; Fathi A. Djouider; Andrew Nisbet

doi:10.2478/nuka-2021-0008

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Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Nukleonika

Volume 66 (2021): Issue 2 (June 2021)

By: Fouad A. Abolaban , Essam M. Banoqitah, Eslam M. Taha, Abdulsalam M. Alhawsawi, Fathi A. Djouider and Andrew Nisbet

Open Access

|Jun 2021

Abstract

Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl₂ target may provide a feasible design outline for an Ac-225 generator.

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Articles in this issue

DOI: https://doi.org/10.2478/nuka-2021-0008 | Journal eISSN: 1508-5791 | Journal ISSN: 0029-5922

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Language: English

Page range: 61 - 67

Submitted on: Aug 18, 2020

Accepted on: Apr 6, 2021

Published on: Jun 8, 2021

Published by: Institute of Nuclear Chemistry and Technology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

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© 2021 Fouad A. Abolaban, Essam M. Banoqitah, Eslam M. Taha, Abdulsalam M. Alhawsawi, Fathi A. Djouider, Andrew Nisbet, published by Institute of Nuclear Chemistry and Technology
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Volume 66 (2021): Issue 2 (June 2021)