Have a personal or library account? Click to login
Skin Impedance Analysis for Drug Delivery: Integration of Poisson–Boltzmann–Nernst–Planck Model and Ebola Optimisation Algorithm Cover

Skin Impedance Analysis for Drug Delivery: Integration of Poisson–Boltzmann–Nernst–Planck Model and Ebola Optimisation Algorithm

By: L Maceal Tony and  R.S Shaji  
Open Access
|Dec 2025

References

  1. Dinu, M., Tatu, A. L., Cocoș, D. I., Nwabudike, L. C., Chirilov, A. M., Stefan, C. S., Earar, K., Dumitriu Buzia, O. D. (2024). Natural sources of therapeutic agents used in skin conditions. Life, 14 (4), 492. https://doi.org/10.3390/life14040492
  2. Nicze, M., Borówka, M., Dec, A., Niemiec, A., Bułdak, Ł., Okopień, B. (2024). The current and promising oral delivery methods for protein- and peptide-based drugs. International Journal of Molecular Sciences, 25 (2), 815. https://doi.org/10.3390/ijms25020815
  3. Heraudeau, M., Roux, C. M., Lahogue, C., Largilliere, S., Allouche, S., Lelong-Boulouard, V., Freret, T. (2023). Micropipette-guided Drug Administration (MDA) as a non-invasive chronic oral administration method in male rats. Journal of Neuroscience Methods, 398, 109951. https://doi.org/10.1016/j.jneumeth.2023.109951
  4. García, J., Ríos, I., Fonthal Rico, F. (2019). Design and analyses of a transdermal drug delivery device (TD3). Sensors, 19 (23), 5090. https://doi.org/10.3390/s19235090
  5. Phatale, V., Vaiphei, K. K., Jha, S., Patil, D., Agrawal, M., Alexander, A. (2022). Overcoming skin barriers through advanced transdermal drug delivery approaches. Journal of Controlled Release, 351, 361–380. https://doi.org/10.1016/j.jconrel.2022.09.025
  6. Goyal, K., Borkholder, D. A., Day, S. W. (2022). Dependence of skin-electrode contact impedance on material and skin hydration. Sensors, 2 (21), 8510. https://doi.org/10.3390/s22218510
  7. Ordiz, I., Vega, J. A., Martín-Sanz, R., García-Suárez, O., del Valle, M. E., Feito, J. (2021). Transdermal drug delivery in the pig skin. Pharmaceutics, 13 (12), 2016. https://doi.org/10.3390/pharmaceutics13122016
  8. Murphy, B. B., Scheid, B. H., Hendricks, Q., Apollo, N. V., Litt, B., Vitale, F. (2021). Time evolution of the skin–electrode interface impedance under different skin treatments. Sensors, 21 (15), 5210. https://doi.org/10.3390/s21155210
  9. Wang, Y., Zeng, L., Song, W., Liu, J. (2022). Influencing factors and drug application of iontophoresis in transdermal drug delivery: An overview of recent progress. Drug Delivery and Translational Research, 12, 15–26. https://doi.org/10.1007/s13346-021-00898-6
  10. Bok, M., Kwon, Y. I., Huang, Z. M., Lim, E. (2023). Portable iontophoresis device for efficient drug delivery. Bioengineering, 10 (1), 88. https://doi.org/10.3390/bioengineering10010088
  11. Li, Y., Yang, J., Zheng, Y., Ye, R., Liu, B., Huang, Y., Zhou, W., Jiang, L. (2021). Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery. Acta Biomaterialia, 121, 349–358. https://doi.org/10.1016/j.actbio.2020.12.023
  12. Liu, L., Zhao, W., Ma, Q., Gao, Y., Wang, W., Zhang, X., Dong, Y., Zhang, T., Liang, Y., Han, S., Cao, J., Wang, X., Sun, W., Ma, H., Sun, Y. (2023). Functional nano-systems for transdermal drug delivery and skin therapy. Nanoscale Advances, 5 (6), 1527–1558. https://doi.org/10.1039/D2NA00530A
  13. Khan, S. U., Ullah, M., Saeed, S., Saleh, E. A. M., Kassem, A. F., Arbi, F. M., Wahab, A., Rehman, M., ur Rehman, K., Khan, D., Zaman, U., Khan, K. A., Khan, M. A., Lu, K. (2024). Nanotherapeutic approaches for transdermal drug delivery systems and their biomedical applications. European Polymer Journal, 207, 112819. https://doi.org/10.1016/j.eurpolymj.2024.112819
  14. Rinaldi, A. O., Korsfeldt, A., Ward, S., Burla, D., Dreher, A., Gautschi, M., Stolpe, B., Tan, G., Bersuch, E., Melin, D., Lord, N. A., Grant, S., Svedenhag, P., Tsekova, K., Schmid-Grendelmeier, P., Möhrenschlager, M., Renner, E. D., Akdis, C. A. (2021). Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis. Allergy, 76 (10), 3066–3079. https://doi.org/10.1111/all.14842
  15. Fortune, B. C., Pretty, C. G., Cameron, C. J., McKenzie, L. R., Chatfield, L. T., Hayes, M. P. (2021). Electrode–skin impedance imbalance measured in the frequency domain. Biomedical Signal Processing and Control, 63, 102202. https://doi.org/10.1016/j.bspc.2020.102202
  16. Qiao, Z., Xu, Z., Yin, Q., Zhou, S. (2023). Structure-preserving numerical method for Maxwell-Ampère Nernst-Planck model. Journal of Computational Physics, 475, 111845. https://doi.org/10.1016/j.jcp.2022.111845
  17. Rosseto, M. P., Evangelista, L. R., Lenzi, E. K., Zola, R. S., Ribeiro de Almeida, R. R. (2022). Frequency-dependent dielectric permittivity in Poisson–Nernst–Planck model. The Journal of Physical Chemistry B, 126 (34), 6446–6453. https://doi.org/10.1021/acs.jpcb.2c03663
  18. Ehtiati, K., Eiler, J., Bochynska, A., Nissen, L. L., Strøbech, E., Nielsen, L. F., Thormann, E. (2023). Skin and artificial skin models in electrical sensing applications. ACS Applied Bio Materials, 6 (8), 3033–3051. https://doi.org/10.1021/acsabm.3c00356
  19. Bora, D. J., Dasgupta, R. (2020). Sensitivity of montague model of skin for predicting physiological variation in skin layers. In 2020 International Conference on Contemporary Computing and Applications (IC3A). IEEE, 13–16. https://doi.org/10.1109/IC3A48958.2020.233260
  20. Bora, D. J., Dasgupta, R. (2020). Estimation of skin impedance models with experimental data and a proposed model for human skin impedance. IET Systems Biology, 14 (5), 230–240. https://doi.org/10.1049/iet-syb.2020.0049
  21. Ghoneim, M. S., Mohammaden, A., Said, L. A., Madian, A. H., Radwan, A. G., Eltawil, A. M. (2021). A comparative study of different human skin impedance models. In 2021 38th National Radio Science Conference (NRSC). IEEE, 271–277. https://doi.org/10.1109/NRSC52299.2021.9509823
  22. Holm, S., Holm, T., Martinsen, Ø. G. (2021). Simple circuit equivalents for the constant phase element. PloS One, 16 (3), e0248786. https://doi.org/10.1371/journal.pone.0248786
  23. Bora, D. J. (2023). A study of the characteristics of Skin Impedance Models based on the simulation of models. In 2023 IEEE 8th International Conference for Convergence in Technology (I2CT). IEEE. https://doi.org/10.1109/I2CT57861.2023.10126190
  24. Oyelade, O. N., Ezugwu, A. E.-S., Mohamed, T. I. A., Abualigah, L. (2022). Ebola optimization search algorithm: A new nature-inspired metaheuristic optimization algorithm. IEEE Access, 10, 16150–16177. https://doi.org/10.1109/ACCESS.2022.3147821
  25. Kwon, I., Kwak, D. Y., Jo, G. (2021). Discontinuous bubble immersed finite element method for Poisson–Boltzmann–Nernst–Planck model. Journal of Computational Physics, 438, 110370. https://doi.org/10.1016/j.jcp.2021.110370
  26. Xie, Y., He, J., Li, S., Chen, X., Zhang, T., Zhao, Y., Lin, Y., Cai, X. (2023). A transdermal drug delivery system based on nucleic acid nanomaterials for skin photodamage treatment. Advanced Functional Materials, 33 (46), 2303580. https://doi.org/10.1002/adfm.202303580
  27. Limcharoen, B., Wanichwecharungruang, S., Banlunara, W., Darvin, M. E. (2025). Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles. Advanced Drug Delivery Reviews, 217, 115478. https://doi.org/10.1016/j.addr.2024.115478
  28. Massot, B., Desmazure, E., Montalibet, A., McAdams, E., Gehin, C. (2024). A portable device performing continuous impedance spectroscopy for skin conductivity. IEEE Sensors Journal, 24 (24), 41125–41135. https://doi.org/10.1109/JSEN.2024.3485187
  29. Rowe, D., Rowe, M. (2024). Characterising skin electrical impedance using tape stripping methods: A bioelectrical study of a porcine model. Cureus, 16 (8), e66566. https://doi.org/10.7759/cureus.66566
Language: English
Page range: 347 - 357
Submitted on: Mar 12, 2025
|
Accepted on: Jul 25, 2025
|
Published on: Dec 23, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2025 L Maceal Tony, R.S Shaji, published by Slovak Academy of Sciences, Institute of Measurement Science
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.