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Fluorescent yttrium oxide nanoparticles for sensitive detection of vitamin B12: Synthesis, characterization, and sensor development Cover

Fluorescent yttrium oxide nanoparticles for sensitive detection of vitamin B12: Synthesis, characterization, and sensor development

Open Access
|Nov 2025

References

  1. Chaudhary, P., Fatima, F., Kumar, A., Relevance of nanomaterials in food packaging and its advanced future prospects, J. Inorg. Organomet. Polym. Mater., 2020, 30: 5180–5192
  2. Aresta, A., Calvano, C.D., Trapani, A., Cellamare, S., Zambonin, C.G., De Giglio, E., Development and analytical characterization of vitamin(s)-loaded chitosan nanoparticles for potential food packaging applications, J. Nanopart. Res., 2013, 15: 1592
  3. Jafari, M, Mousavi, M., Shirzad, K., Hosseini, M.A., Badiei, A., Pourhakkak, P., et al., A TiO₂ nanotube array decorated by Ag nanoparticles for highly sensitive SERS determination and self-cleaning of vitamin B12, Microchem. J., 2022, 181: 107813
  4. Schmidt, A., Call, L.M., Macheiner, L., Mayer, H.K., Determination of vitamin B12 in four edible insect species by immunoaffinity and ultra-high performance liquid chromatography, Food Chem., 2019, 281: 124–129
  5. Layden, A.J., Täse, K., Finkelstein, J.L., Neglected tropical diseases and vitamin B12: a review of the current evidence, Trans. R. Soc. Trop. Med. Hyg., 2018, 112: 423–435
  6. Duhan, J., Saini, S., Kumar, H., Obrai, S., BPGQD/g-C3N4 nanocomposites as sensitive and selective platform for fluorescence and RGB based detection of vitamin B12, J. Lumin., 2024, 275: 120764
  7. Zhu, X., Wang, X., Zhang, C., Wang, X., Gu, Q., A riboswitch sensor to determine vitamin B12 in fermented foods, Food Chem., 2015, 175: 523–528
  8. Antherjanam, S., Saraswathyamma, B., Krishnan, R.G., Gopakumar, G.M., Electrochemical sensors as a versatile tool for the quantitative analysis of vitamin B12, Chem. Pap., 2021, 75: 2981–2995
  9. Gharibzahedi, S.M.T., Moghadam, M., Amft, J., Tolun, A., Hasabnis, G., Altintas, Z., Recent advances in dietary sources, health benefits, emerging encapsulation methods, food fortification, and new sensor-based monitoring of vitamin B12: a critical review, Molecules, 2023, 28: 7469
  10. Lu, Q., Feng, Y., Zhou, Q., Yang, T., Kuang, H., Xu, C., et al., A time-resolved fluorescent microsphere immunochromatographic assay for determination of vitamin B12 in infant formula milk powder, Biosensors, 2025, 15: 65
  11. Jardan, Y.A.B., Mostafa, A.M., Barker, J., Ali, A.B.H., El-Wekil, M.M., A novel route for fabrication of yellow emissive carbon dots for selective and sensitive detection of vitamin B12, Anal. Methods, 2025, 17: 3007–3016
  12. Gharibzahedi, S.M.T., Hasabnis, G.K., Akin, E., Altintas, Z., Molecularly imprinted polymers-based electrochemical sensors for tracking vitamin B12 released from spray-dried microcapsules during in vitro simulated gastrointestinal digestion, Sens. Bio-Sens. Res., 2025, 47: 100759
  13. Almutib, E., Alasmari, A., Alhashmialameer, D., Algarni, Z.S., Alrahili, M.R., Alzahrani, A., et al., Characterization of cobalt-substituted cadmium ferrites CoxCd1−xFe2O4: structural, optical, and magnetic insights, Appl. Phys. A, 2025, 131: 77
  14. Shariq, M., Madkhli, A.Y., Kawtherali, S.F., Alshehri, K., Alasmari, A., Algarni, Z.S., et al., Recent advancement in development of nitrogen-doped CQDs for dye sensitized solar cell and photodetector: a review, Surf. Interfaces, 2025, 59: 10591
  15. Hussain, M., Hussaini, S.S., Shariq, M., Althikrallah, H.A., Al-Qasmi, N., Seku, K., et al., Efficient removal of rhodamine B dye using myrrh-based magnetized multi-walled carbon nanotubes as adsorbent, Adsorption, 2024, 30: 1925–1936
  16. Alhashmialameer, D., Shariq, M., Althikrallah, H.A., Al-Amari, M., BaQais, A., Alayyafi, A.A., et al., Hydrothermally synthesized Nb-doped TiO₂ nanosheets for efficient removal of methylene blue dye on photocatalytic performance, Phys. Scr., 2024, 99: 085915
  17. Qamar, M.A., Al-Gethami, W., Alaghaz, A.N.M.A., Shariq, M., Mohammed, A., Areshi, A.A., et al., Progress in the development of phyto-based materials for adsorption of dyes from wastewater: a review, Mater. Today Commun., 2024, 38: 108385
  18. Hussain, M, Hussaini, S.S., Shariq, M., Alzahrani, H., Alholaisi, A.A., Alharbi, S.H., et al., Enhancing Cu2⁺ ion removal: an innovative approach utilizing modified frankincense gum combined with multiwalled carbon tubes and iron oxide nanoparticles as adsorbent, Molecules, 2023, 28: 4494
  19. Magdalane, C.M., Kaviyarasu, K., Vijaya, J.J., Siddhardha, B., Jeyaraj, B., Facile synthesis of heterostructured cerium oxide/yttrium oxide nanocomposite in UV light induced photocatalytic degradation and catalytic reduction: synergistic effect of antimicrobial studies, J. Photochem. Photobiol. B Biol., 2017, 173: 23–34
  20. El-Shafai, N.M., Ramadan, M.S., El-Mehasseb, I.M., Decoration of modified self-assembly membrane by magnesium oxide and yttrium oxide nanoparticles for biosensors, supercapacitors, and water treatment, Int. J. Energy Res., 2022, 46: 18029–18048
  21. Rajakumar, G., Mao, L., Bao, T., Wen, W., Wang, S., Gomathi, T., et al., Yttrium oxide nanoparticle synthesis: an overview of methods of preparation and biomedical applications, Appl. Sci., 2021, 11: 2172
  22. Sun, H., Yao, B., Han, Y., Yang, L., Zhao, Y., Wang, S., et al., Multi-interface engineering of self-supported nickel/yttrium oxide electrode enables kinetically accelerated and ultra-stable alkaline hydrogen evolution at industrial-level current density, Adv. Energy Mater., 2024, 14: 2303563
  23. Yousaf, F., Irfan, M., Plant-mediated synthesis of yttrium oxide nanoparticles vs. traditional methods: current trends and potential applications, BioNanoScience, 2024, 14: 3889–3905
  24. Niederberger, M., Pinna, N., Metal oxide nanoparticles in organic solvents: synthesis, formation, assembly and application, Springer Sci. Bus. Media, 2009
  25. Curtis, C.E., Properties of yttrium oxide ceramics, J. Am. Ceram. Soc., 1957, 40: 274–278
  26. Sowjanya, M., Shariq, M., Alajlani, Y., Pamu, D., Chowdhruy, R., Jayaganthan, R., et al., Effect of Ar: O2 gas atmosphere on optical properties of Y2O3-doped ZnO thin films by RF sputtering, Europhys. Lett., 2022, 129(3), 34003
  27. Wang, Y.-Y., Gao, M.-Y., Liu, S., Li, G.-R., Gao, X.-P., Yttrium surface gradient doping for enhancing structure and thermal stability of high-Ni layered oxide as cathode for Li-ion batteries, ACS Appl. Mater. Interfaces, 2021, 13: 7343–7354
  28. Govindasamy, R., Govindarasu, M., Alharthi, S.S., Mani, P., Bernaurdshaw, N., Gomathi, T., et al., Sustainable green synthesis of yttrium oxide (Y₂O₃) nanoparticles using Lantana camara leaf extracts: physicochemical characterization, photocatalytic degradation, antibacterial, and anticancer potency, Nanomaterials, 2022, 12: 2393
  29. Jay Chithra, M., Sathya, M., Pushpanathan, K.J.A.M.S., Effect of pH on crystal size and photoluminescence property of ZnO nanoparticles prepared by chemical precipitation method, Acta Metall. Sin. (Eng. Lett.), 2015, 28: 394–404
  30. Chen, C., He, H., Lu, Y., Wu, K., Ye, Z., Surface passivation effect on the photoluminescence of ZnO nanorods, ACS Appl. Mater. Interfaces, 2013, 5: 6354–6359
  31. Duhan, J., Obrai, S., Highly sensitive and selective fluorescence and smartphone-based sensor for detection of L-dopa using nitrogen sulphur graphene quantum dots, Microchem. J., 2023, 193: 109262
  32. Den Engelsen, D., Harris, P.G., Ireland, T.G., Fern, G., Silver, J., Symmetry-related transitions in the spectrum of nanosized cubic Y2O3:Tb3⁺, ECS J. Solid. State Sci. Technol., 2015, 4: R105–R113
  33. Kohlmann, T., Goez, M., Combined static and dynamic intramicellar fluorescence quenching: effects on stationary and time-resolved Stern–Volmer experiments, Phys. Chem. Chem. Phys., 2019, 21: 10075–10085
  34. Duhan, J., Obrai, S., Samarium, nitrogen co-doped carbon dots for detection of epinephrine: theoretical and experimental, J. Ind. Eng. Chem., 2025, 142: 582–592
  35. Chapman, J., Truong, V.K., Elbourne, A., Gangadoo, S., Cheeseman, S., Rajapaksha, P., et al., Combining chemometrics and sensors: toward new applications in monitoring and environmental analysis, Chem. Rev., 2020, 120: 6048–6069
  36. Kumar, P.S., Sundaramurthy, J., Sundarrajan, S., Babu, V.J., Singh, G., Allakhverdiev, S.I., et al., Hierarchical electrospun nanofibers for energy harvesting, production and environmental remediation, Energy Environ. Sci., 2014, 7: 3192–3222
  37. Gai, S., Li, C., Yang, P., Lin, J., Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications, Chem. Rev., 2014, 114: 2343–2389
  38. Duhan, J., Obrai, S., Lanthanum nitrogen co-doped carbon quantum dots as optical and smartphone sensors for serotonin detection, Opt. Mater., 2023, 145: 114466
  39. Srinivasan, R., Yogamalar, R., Bose, A.C., Structural and optical studies of yttrium oxide nanoparticles synthesized by co-precipitation method, Mater. Res. Bull., 2010, 45: 1165–1170
  40. Viswanath, R., Naik, H.S.B., Somalanaik, Y.K.G., Neelanjeneallu, P.K.P., Harish, K.N., Prabhakara, M.C., Studies on characterization, optical absorption, and photoluminescence of yttrium doped ZnS nanoparticles, J. Nanotechnol., 2014, 2014: 924797–924798
  41. Parangusan, K., Subramanium, V., Sundarabharathi, L., Kannan, K., Radhika, D., Influence of pH on structural, morphological, optical, photocatalytic, and antibacterial properties of yttrium oxide nanoparticles via co-precipitation method, Mater. Chem. Phys., 2021, 276: 125431
  42. Hu, J., Sun, Y., Aryee, A.A., Qu, L., Zhang, K., Li, Z., Mechanisms for carbon dots-based chemosensing, biosensing, and bioimaging: a review, Anal. Chim. Acta, 2022, 1209: 338885
  43. Tanwar, A.S., Hussain, S., Malik, A.H., Afroz, M.A., Iyer, P.K., Inner filter effect based selective detection of nitroexplosive-picric acid in aqueous solution and solid support using conjugated polymer, ACS Sens., 2016, 1: 1070–1077
  44. Oladipo, A.A., Oskouei, S.D., Gazi, M., Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: a review, Beilstein J. Nanotechnol., 2023, 14: 631–673
  45. Singh, D.P., Inamdar, S.R., Kumar, S., Fluorescence spectrometry, in Modern Techniques of Spectroscopy: Basics, Instrumentation, and Applications, 2021, pp. 431–468
  46. Duhan, J., Obrai, S., Sodium vanadates doped boron phosphorus graphene quantum dots: a novel nanosensor for the fluorescence detection of rutin, Food Chem., 2024, 460: 140630
  47. Kannouma, R.E., Kamal, A.H., Hammad, M.A., Mansour, F.R., Tips and tricks for applying luminescent carbon dots in chemical analysis: recent advancements, obstacles, and future outlook, Microchem. J., 2024, 192: 111667
  48. Ahmad, M., Bushra, R., Ritzoulis, C., Pectin–mucin interactions: insights from fluorimetry, thermodynamics and dual (static and dynamic) quenching mechanisms, Int. J. Biol. Macromol., 2024, 277: 134564
  49. Hunt, B., Ruiz, A.J., Pogue, B.W., Smartphone-based imaging systems for medical applications: a critical review, J. Biomed. Opt., 2021, 26: 040902
  50. Banik, S., Melanthota, S.K., Arbaaz, Vaz, J.M., Kadambalithaya, V.M., Hussain, I., et al., Recent trends in smartphone-based detection for biomedical applications: a review, Anal. Bioanal. Chem., 2021, 413: 2389–2406
  51. Duhan, J., Kumar, H., Obrai, S., Fabrication and DFT study of IFE based nano-sensor for fluorometric detection of norepinephrine, Opt. Laser Technol., 2024, 174: 110665
  52. Kumar, H., Duhan, J., Obrai, S., Highly sensitive and selective fluorescence and smartphone-based sensor for detection of rutin using boron nitrogen co-doped graphene quantum dots, J. Fluoresc., 2024, 34: 1–13
  53. Mohamed, G.G., Fekry, A.M., Abou Attia, F.M., Ibrahim, N.S., Azab, S.M., Simultaneous determination of some antidepressant drugs and vitamin B12 in pharmaceutical products and urine sample using HPLC method, J. Chromatogr. B, 2020, 1150: 122178
  54. Chalissery, P., Homann, C., Stepp, H., Eisel, M., Aumiller, M., Rühm, A., et al., Influence of vitamins and food on the fluorescence spectrum of human urine, Lasers Surg. Med., 2024, 56: 485–495
  55. Noreldeen, H.A.A., Huang, K.Y., Wu, G.W., Peng, H.P., Deng, H.H., Chen, W., Deep learning-based sensor array: 3D fluorescence spectra of gold nanoclusters for qualitative and quantitative analysis of vitamin B6 derivatives, Anal. Chem., 2022, 94: 9287–9296
DOI: https://doi.org/10.2478/msp-2025-0038 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
Language: English
Page range: 202 - 215
Submitted on: Aug 15, 2025
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Accepted on: Nov 4, 2025
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Published on: Nov 22, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Salma Alshehri, Mohammad Shariq, Wafa Al-Gethami, Aisha H. Al-Moubaraki, M. D. Alshahrani, Nouf Alharbi, Hind S. Alzahrani, Noha Al-Qasmi, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.