Have a personal or library account? Click to login
Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study Cover

Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

Materials Science-Poland
Volume 42 (2024): Issue 2 (June 2024)
By: Yongcai Song,  Yujia Su,  Shaik Althaf Hussain and  Cuiping Tang  
Open Access
|Jun 2024

Figures & Tables

Fig. 1.

SEM images of (A) RESALNPs, (B) PREALNPs, and (C) drug-free ALNPs. Right panel shows the size distribution of each nanocarrier

Fig. 2.

MTT assay with MG-63 cells cultured with RESALNPs, PREALNPs, and ALNPs during 7-day culture. * shows p-value < 0.05

Fig. 3.

Anti-inflammatory assay results with RESAL-NPs and PREALNPs compared with ALNPs and cells cultured with the normal media as the control group, * shows p-value < 0.05

Fig. 4.

Release of resveratrol and prednisolone from ALNPs during the course of 14 days in PBS

Fig. 5.

Hematoxylin and Eosin (H&E) and Masson’s trichrome staining images of cartilage tissue in different groups

Fig. 6.

Tissue concentrations of TNF-α, TGF-β, and IL-6 in cartilage tissue treated with different nanocarriers, * shows p-value < 0.05

DLS assessment results

Sample nameHydrodynamic sizeZeta potential
RESALNPs504.067 ± 30.38 nm−26.05 ± 6.60 mV
PREALNPs499.91 ± 55.68 nm−24.93 ± 9.94 mV
ALNPs536.90 ± 42.30 nm−26.33 ± 3.21 mV
DOI: https://doi.org/10.2478/msp-2024-0005 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
Journal RSS Feed
Language: English
Page range: 16 - 25
Submitted on: Dec 15, 2023
|
Accepted on: Apr 24, 2024
|
Published on: Jun 28, 2024
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
resveratrol,
prednisolone,
rheumatoid arthritis,
albumin nanoparticles
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2024 Yongcai Song, Yujia Su, Shaik Althaf Hussain, Cuiping Tang, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Previous articleVolume 42 (2024): Issue 2 (June 2024)Next article