Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

Song, Yongcai; Su, Yujia; Hussain, Shaik Althaf; Tang, Cuiping

doi:10.2478/msp-2024-0005

Abstract

Rheumatoid arthritis is a chronic autoimmune-disease-causing inflammation, joint pain, and joint destruction, severely affecting the quality of life of millions worldwide. In the current research, a nanocarrier system was developed for the delivery of resveratrol and prednisolone to treat rheumatoid arthritis. The drug delivery system was characterized in vitro using scanning electron microscopy and various cell culture studies. Finally, the alleviative symptoms of the developed treatment strategy were investigated in a rat model of rheumatoid arthritis. In vitro studies showed that the carrier system released the drugs in a sustained manner and possessed strong immunomodulatory functions. Nanocarriers loaded with prednisolone, resveratrol, and drug-free carriers had 396.88 ± 76.41 nm, 392.49 ± 97.31 nm, and 338.02 ± 77.75 nm of mean particle size, respectively. In vivo studies revealed that local injection of the carrier system could alleviate the degenerative effects of rheumatoid arthritis. ELISA assays showed that the co-injection of resveratrol and prednisolone-loaded albumin nanoparticles could significantly modulate inflammatory responses. The developed treatment modality may potentially be used to treat rheumatoid arthritis.

References

Radu A-F, and Bungau SG. Management of rheumatoid arthritis: an overview. Cells. 2021;10(11): 2857. doi: 10.3390/cells10112857
Open DOI Search in Google Scholar Back to article
Conigliaro P, et al. Challenges in the treatment of rheumatoid arthritis. Autoimmun Rev. 2019;18(7):706–713. doi: 10.1016/j.autrev.2019.05.007
Open DOI Search in Google Scholar Back to article
Dedmon LE. The genetics of rheumatoid arthritis. Rheumatology. 2020;59(10):2661–2670. doi: 10.1093/rheumatology/keaa232
Open DOI Search in Google Scholar Back to article
Nguyen TT, et al. Nanotechnology-based drug delivery for central nervous system disorders. Biomed Pharmacother. 2021;143:112117. doi: 10.1016/j.biopha.2021.112117
Open DOI Search in Google Scholar Back to article
Sim S, Wong NK. Nanotechnology and its use in imaging and drug delivery. Biomed Rep. 2021;14(5):1–9. doi: 10.3892/br.2021.1418
Open DOI Search in Google Scholar Back to article
Shaito A, et al. Potential adverse effects of resveratrol: A literature review. Int J Mol Sci. 2020;21(6):2084. doi: 10.3390/ijms21062084
Open DOI Search in Google Scholar Back to article
Albano GD, et al. Adverse effects of anabolic-androgenic steroids: A literature review. Healthcare. 2021. doi: 10.3390/healthcare9010097
Open DOI Search in Google Scholar Back to article
Parsamanesh N, et al. Resveratrol and endothelial function: A literature review. Pharmacol Res. 2021;170:105725. doi: 10.1016/j.phrs.2021.105725
Open DOI Search in Google Scholar Back to article
Malviya V, et al. A brief review on resveratrol. 2022. doi: 10.52711/2231-5659.2022.00027
Open DOI Search in Google Scholar Back to article
Delmas D, et al. New highlights of resveratrol: A review of properties against ocular diseases. Int J Mol Sci. 2021;22(3):1295. doi: 10.3390/ijms22031295
Open DOI Search in Google Scholar Back to article
Sheng S, et al. The role of resveratrol on rheumatoid arthritis: From bench to bedside. Front Pharmacol. 2022;13:829677. doi: 10.3389/fphar.2022.829677
Open DOI Search in Google Scholar Back to article
Berardicurti O, et al. Glucocorticoids in rheumatoid arthritis: The silent companion in the therapeutic strategy. Expert Rev Clin Pharmacol. 2020;13(6):593–604. doi: 10.1080/17512433.2020.1772055
Open DOI Search in Google Scholar Back to article
De Andrade J, McCormick J, Hill A. Small doses of prednisolone in the management of rheumatoid arthritis. Ann Rheum Dis. 1964;23(2):158. doi: 10.1136/ard.23.2.158
Open DOI Search in Google Scholar Back to article
Ethgen O, et al. What do we know about the safety of corticosteroids in rheumatoid arthritis? Curr Med Res Opin. 2013;29(9):1147–1160. doi: 10.1185/03007995.2013.818531
Open DOI Search in Google Scholar Back to article
Viscido A, et al. Nanotechnology in the treatment of inflammatory bowel diseases. J Crohns Colitis. 2014;8(9):903–918. doi: 10.1016/j.crohns.2014.02.024
Open DOI Search in Google Scholar Back to article
Kianfar E, et al. Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles. J Nanobiotechnol. 2021;19(1):159. doi: 10.1186/s12951-021-00896-3
Open DOI Search in Google Scholar Back to article
Meng R, et al. Preparation of drug-loaded albumin nanoparticles and its application in cancer therapy. J Nanomater. 2022;2022:1–12. doi: 10.1155/2022/305 2175
Open DOI Search in Google Scholar Back to article
Solanki R, Patel K, Patel S. Bovine serum albumin nanoparticles for the efficient delivery of berberine: Preparation, characterization and in vitro biological studies. Colloids Surf A Physicochem Eng Asp. 2021;608:125501. doi: 10.1016/j.colsurfa.2020.125501
Open DOI Search in Google Scholar Back to article
Mitchell MJ, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–124. doi: 10.1038/s41573-020-0090-8
Open DOI Search in Google Scholar Back to article
Begines B, et al. Polymeric nanoparticles for drug delivery: Recent developments and future prospects. Nanomaterials. 2020;10(7):1403. doi: 10.3390/nano1071403
Open DOI Search in Google Scholar Back to article
Liu R, et al. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chin Chem Lett. 2023;34(2):107518. doi: 10.1016/j.cclet.2022.05. 032
Open DOI Search in Google Scholar Back to article
Amighi F, Emam-Djomeh Z, Labbafi-Mazraeh-Shahi M. Effect of different cross-linking agents on the preparation of bovine serum albumin nanoparticles. J Iranian Chem Soc. 2020;17:1223–1235. doi: 10.1007/s13738-0 19-01850-9
Open DOI Search in Google Scholar Back to article
Solanki R, et al. Anticancer nano-delivery systems based on bovine serum albumin nanoparticles: A critical review. Int J Biol Macromol. 2021;193:528–540. doi: 10.1016/j.ijbiomac.2021.10.040
Open DOI Search in Google Scholar Back to article
Hornok V. Serum albumin nanoparticles: Problems and prospects. Polymers. 2021;13(21):3759. doi: 10.3390/po lym13213759
Open DOI Search in Google Scholar Back to article
Gaballa SA, et al. Corticosteroids in ophthalmology: Drug delivery innovations, pharmacology, clinical applications, and future perspectives. Drug Deliv Transl Res. 2021;11:866–893. doi: 10.1007/s13346-020-00843-z
Open DOI Search in Google Scholar Back to article
Meng T, et al. Anti-inflammatory action and mechanisms of resveratrol. Molecules. 2021;26(1):229. doi: 10.3390/molecules26010229
Open DOI Search in Google Scholar Back to article
Chamundeeswari M, Jeslin J, Verma ML. Nanocarriers for drug delivery applications. Environ Chem Lett. 2019;17:849–865. doi: 10.1007/s10311-018-00841-1
Open DOI Search in Google Scholar Back to article
Morselli E, et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010;1(1):e10. doi: 10.1038/cddis.2009.8
Open DOI Search in Google Scholar Back to article
Peng Y, et al. Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF-κB–Mediated preosteoclast pdgfb transcription in young mice. J Bone Miner Res. 2020;35(6):1188–1202. doi: 10.1002/jbmr.3987
Open DOI Search in Google Scholar Back to article
Matthay MA, Wick KD. Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome. J Clin Invest. 2020;130(12):6218–6221. doi: 10.1172/JC I143331
Open DOI Search in Google Scholar Back to article

Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

Abstract

Paradigm

My account