Effect of oxidative status on the occurrence of haemolactia in dairy cows after calving

Kuroiwa, Tomoko; Matsuda, Keiichi; Kanazawa, Tomomi; Chee, Hueyshy; Kimura, Atsushi; Satoh, Hiroshi; Sato, Shigeru; Ichijo, Toshihiro

doi:10.2478/jvetres-2022-0025

Abstract

Introduction

Dairy cows may infrequently give milk tinged with blood after calving, which is a condition termed haemolactia. Economic losses for dairy farmers are caused by cases of haemolactia because of the condemnation of such milk, potential contamination of good bulk tank milk with haemolactic milk, and need for veterinarian intervention. This study was performed to elucidate the oxidative status of dairy cows with haemolactia during the peripartum period.

Material and Methods

Plasma glutathione peroxidase, malondialdehyde (MDA) and superoxide dismutase concentrations along with serum vitamin A, C and E concentrations were determined as indices of oxidative stress. The sampled dairy cows comprised two haemolactic (n = 11 and n = 6) and two non-haemolactic (n = 11 and n = 6) groups.

Results

On the first day when haemolactia was identified in colostrum (at mean 2.1 days after parturition), a significantly increased concentration of plasma MDA was noted in the haemolactic group. During the prepartum period, low levels of serum vitamin E were continuously observed from prepartum week 4 to the parturition day but only in the haemolactic group.

Conclusion

These results demonstrate that continuous low levels of serum vitamin E in the prepartum period may play a pivotal role as a requisite factor in the onset of haemolactia after calving.

References

Abuelo A., Hernández J., Benedito J.L., Castillo C.: The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation. J Anim Physiol Anim Nutr 2015, 99, 1003–1016, doi: 10.1111/jpn.12273.
Open DOI Search in Google Scholar Back to article
Abuelo A., Hernández J., Benedito J.L., Castillo C.: Redox biology in transition periods of dairy cattle: role in the health of periparturient and neonatal animals. Antioxidants 2019, 8, 20, doi:10.3390/antiox8010020.
Open DOI Search in Google Scholar Back to article
Bani Ismail Z., Abutarbush S.M., Al-Qudah K., Omoush F.: Serum and milk concentrations of oxidant and anti-oxidant markers in dairy cows affected with bloody milk. Pol J Vet Sci 2020, 23, 341–347, doi: 10.24425/pjvs.2020.133651.
Open DOI Search in Google Scholar Back to article
Bernabucci U., Ronchi B., Lacetera N., Nardone A.: Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. J Dairy Sci 2005, 88, 2017–2026, doi: 10.3168/jds. S0022-0302(05)72878-2.
Open DOI Search in Google Scholar Back to article
Blood D.C., Radostits O.M.: Veterinary medicine Seventh Edition, Bailliere Trindall, London, UK, 1989.
Search in Google Scholar Back to article
Bouwstra R.J., Nielen M., Stegeman J.A., Dobbelaar P., Newbold J.R., Jansen E.H.J.M., van Werven T.: Vitamin E supplementation during the dry period in dairy cattle. Part I: Adverse effect on incidence of mastitis postpartum in a double-blind randomized field trial. J Dairy Sci 2010, 93, 5684–5695, doi: 10.3168/jds.2010-3159.
Open DOI Search in Google Scholar Back to article
Bradford P.S.: Large animal internal medicine Third Edition, Mosby, Maryland Heights, MO, 2001.
Search in Google Scholar Back to article
Castillo C., Hernández J., Bravo A., López-Alonso M., Pereira V., Benedito J.L.: Oxidative status during late pregnancy and early lactation in dairy cows. Vet J 2005, 169, 286–292, doi: 10.1016/j.tvjl.2004.02.001.
Open DOI Search in Google Scholar Back to article
Castillo C., Hernández J., Valverde I., Pereira V., Sotillo J., López-Alonso M., Benedito J.L.: Plasma malonaldehyde (MDA) and total antioxidants status (TAS) during lactation in dairy cows. Res Vet Sci 2006, 80, 133–139, doi: 10.1016/j.rvsc.2005.06.003.
Open DOI Search in Google Scholar Back to article
Celi P.: Biomarkers of oxidative stress in ruminant medicine. Immunopharmacol Immunotoxicol 2011, 33, 233–240, doi: 10.3109/08923973.2010.514917.
Open DOI Search in Google Scholar Back to article
Fraile L., Arcas A., Jiménez L.M., Mallo J., Armengol R.: Treatment with etamsylate reduces haemolactia in lactating cows. J Dairy Res 2019, 86, 193–195, doi: 10.1017/S0022029919000219.
Open DOI Search in Google Scholar Back to article
Gitto E., Reiter R.J., Karbownik M., Tan D., Gitto P., Barberi S., Barberi I.: Causes of oxidative stress in the pre- and perinatal period. Biol Neonate 2002, 81, 146–157, doi: 10.1159/000051527.
Open DOI Search in Google Scholar Back to article
Goff J.P., Horst R.L.: Physiological changes at parturition and their relationship to metabolic disorders. J Dairy Sci 1997, 80, 1260–1268, doi: 10.3168/jds. S0022-0302(97)76055-7.
Open DOI Search in Google Scholar Back to article
Johansson B., Persson Waller K., Jensen S.K., Lindqvist H., Nadeau E.: Status of vitamins E and A and β-carotene and health in organic dairy cows fed a diet without synthetic vitamins. J Dairy Sci 2014, 97, 1682–1692, doi: 10.3168/jds.2013-7388.
Open DOI Search in Google Scholar Back to article
Kikuchi T., Ichijo T., Yoshida Y., Kohono M., Murayama I., Takahashi C., Kimura Y., Satoh H.: Bloody milk of the dairy cow: occurrence and somatic cell profiles in Miyagi Prefecture. Jpn J Large Anim Clin 2013, 4, 154–159, doi: 10.4190/jjlac.4.154.
Open DOI Search in Google Scholar Back to article
Politis I.: Reevaluation of vitamin E supplementation of dairy cows: bioavailability, animal health and milk quality. Animal 2012, 6, 1427–1434, doi: 10.1017/S1751731112000225.
Open DOI Search in Google Scholar Back to article
Putman A.K., Brown J.L., Gandy J.C., Wisnieski L., Sordillo L.M.: Changes in biomarkers of nutrient metabolism, inflammation, and oxidative stress in dairy cows during the transition into the early dry period. J Dairy Sci 2018, 101, 9350– 9359, doi: 10.3168/jds.2018-14591.
Open DOI Search in Google Scholar Back to article
Senoh T., Oikawa S., Nakada K., Tagami T., Iwasaki T.: Increased serum malondialdehyde concentration in cows with subclinical ketosis. J Vet Med Sci 2019, 81, 817–820, doi: 10.1292/jvms.18-0777.
Open DOI Search in Google Scholar Back to article
Sordillo L.M., Raphael W.: Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. Vet Clin North Am Food Anim Pract 2013, 29, 267–278, doi: 10.1016/j.cvfa.2013.03.002.
Open DOI Search in Google Scholar Back to article
Tsuchiya Y., Kawahara N., Kim Y.-H., Ichijo T., Sato S.: Changes in oxidative stress parameters in healthy and diseased Holstein cows during the transition period in Yamagata Prefecture, Japan. J Vet Med Sci 2020, 82, 955–961, doi: 10.1292/jvms.20-0024.
Open DOI Search in Google Scholar Back to article
Weiss W.P., Hogan J.S.: Effects of dietary vitamin C on neutrophil function and responses to intramammary infusion of lipopolysaccharide in periparturient dairy cows. J Dairy Sci 2007, 90, 731–739, doi: 10.3168/jds. S0022-0302(07)71557-6.
Open DOI Search in Google Scholar Back to article
Weiss W.P., Hogan J.S., Todhunter D.A., Smith K.L.: Effect of vitamin E supplementation in diets with a low concentration of selenium on mammary gland health of dairy cows. J Dairy Sci 1997, 80, 1728–1737, doi: 10.3168/jds. S0022-0302(97)76105-8.
Open DOI Search in Google Scholar Back to article
Zobel G., Weary D.M., Leslie K.E., von Keyserlingk M.A.G.: Invited review: cessation of lactation: effects on animal welfare. J Dairy Sci 2015, 98, 8263–8277, doi: 10.3168/jds.2015-9617.
Open DOI Search in Google Scholar Back to article