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Developing Fluopyram as a Tool to Combat Beech Leaf Disease in Managed Landscapes and Nurseries Cover

Developing Fluopyram as a Tool to Combat Beech Leaf Disease in Managed Landscapes and Nurseries

Open Access
|Oct 2025

References

  1. Bashian-Victoroff, C., Brown, A., Loyd, A. L., Carrino-Kyker, S. R., and Burke, D. J. 2023. Beech leaf disease severity affects ectomycorrhizal colonization and fungal taxa composition. Journal of Fungi (Basel, Switzerland) 9(4):497. doi: 10.3390/jof9040497
  2. Burns, A. R., Luciani, G. M., Musso, G., Bagg, R., Yeo, M., Zhang, Y., Rajendran, L., Glavin, J., Hunter, R., Redman, E., Stasiuk, S., Schertzberg, M., Angus McQuibban, G., Caffrey, C. R., Cutler, S. R., Tyers, M., Giaever, G., Nislow, C., Fraser, A. G., MacRae, C. A., Gilleard, J., and Roy, P. J. 2015. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nature Communications 6:7485. doi: 10.1038/ncomms8485
  3. Campbell, F. 2022. Urgent update on beech leaf disease. Center for Invasive Species Prevention. https://www.nivemnic.us/?p=3476
  4. Carta, L. K., Handoo, Z. A., Li, S., Kantor, M., Bauchan, G., McCann, D., Gabriel, C. K., Yu, Q., Reed, S., Koch, J., Martin, D., and Burke, D. J. 2020. Beech leaf disease symptoms caused by newly recognized nematode subspecies Litylenchus crenatae mccannii (Anguinata) described from Fagus grandifolia in North America. Forest Pathology 50(2):e12580. doi: 10.1111/efp.12580
  5. Colbert-Pitts, M., Kantor, M. R., Jansen, A., Burke, D. J., and Vieira, P. 2025. Cellular dynamics of beech leaf disease on Fagus sylvatica. Plant Pathology 74(5):1389–1406. doi: 10.1111/ppa.14101
  6. D’Amato, A. W., Orwig, D. A., Siegert, N. W., Mahaffey, A., Benedict, L., Everett, T., Daigle, J., Johnson, L., Catanzaro, P., and Cusack, C. 2023. Species preservation in the face of novel threats: Cultural, ecological, and operational considerations for preserving tree species in the context of non-indigenous insects and pathogens. Journal of Forestry 121(5–6):470–479. doi: 10.1093/jofore/fvad024
  7. Ewing, C. J., Hausman, C. E., Pogacnik, J., Slot, J., and Bonello, P. 2019. Beech leaf disease: An emerging forest epidemic. Forest Pathology 49(2):e12488. doi: 10.1111/efp.12488
  8. Fitza, K. N. E., Allison, J., Slippers, B., Chingandu, N., and Reed, S. E. 2024. Diversity and potential sources of introduction of the beech leaf nematode (Litylenchus crenatae mccannii) to Ontario, Canada. Canadian Journal of Plant Pathology 46(4):356–366. doi: 10.1080/07060661.2024.2312150
  9. Fletcher, L. R., Borsuk, A. M., Fanton, A. C., Johnson, K. M., Richburg, J., Zailaa, J., and Brodersen, C. R. 2024. Anatomical and physiological consequences of beech leaf disease in Fagus grandifolia L. Forest Pathology 54(1):e12842. doi: 10.1111/efp.12842
  10. Goraya, M., Kantor, C., Vieira, P., Martin, D., and Kantor, M. 2024. Deciphering the vectors: Unveiling the local dispersal of Litylenchus crenatae ssp. mccannii in the American beech (Fagus grandifolia) forest ecosystem. PLoS ONE 19(11):e0311830. doi: 10.1371/journal.pone.0311830
  11. Heiken, J. A. 2017. The effects of fluopyram on nematodes. Raleigh, NC, USA: North Carolina State University. https://repository.lib.ncsu.edu/server/api/core/bit-streams/9f7a65f2-12df-44bb-8109-2d32a0d21d62/content
  12. Herms, D. A., Volk, D. R., Hausman, C. E., Persad, A., and Holko, B. L. 2023. Phosphonate soil treatments improve tree health and suppress foliar nematode populations in American beech with beech leaf disease. In Beach Leaf Disease Symposium, Columbus, OH. Society of Nematologists.
  13. Heydari, F., Rodriguez-Crespo, D., and Wicky, C. 2023. The new nematicide cyclobutrifluram targets the mitochondrial succinate dehydrogenase complex in Caenorhabditis elegans. Journal of Developmental Biology 11(4):34. doi: 10.3390/jdb11040039
  14. Hungenberg, H., Fursch, H., Rieck, H., and Hellwege, E. 2013. Use of fluopyram for controlling nematodes in crops and for increasing yield (Patent EP2645856). European Patent Office.
  15. Insecticide Resistance Action Committee (IRAC). 2025. Nematicide Mode of Action Classification Scheme Version 2.2. https://irac-online.org/documents/moa-brochure/?ext=pdf
  16. Jeschke, P. 2024. Recent developments in fluorine-containing pesticides. Pest Management Science 80(7):3065–3087. doi: 10.1002/ps.7921
  17. Kammerer, C. L., Harmon, P. F., and Crow, W. T. 2023. Reduced sensitivity to fluopyram in Meloidogyne graminis following long-term exposure in golf turf. Journal of Nematology 55(1):20230048. doi: 10.2478/jofnem-2023-0048
  18. Kantor, M., Handoo, Z., Kantor, C., and Carta, L. 2022. Top ten most important U.S.-regulated and emerging plant-parasitic nematodes. Horticulturae 8(3):208. doi: 10.3390/horticulturae8030208
  19. Liu, W., Shao, H., Qi, D., Huang, X., Chen, J., Zhou, L., and Guo, K. 2024. The new nematicide cyclobutrifluram targets the mitochondrial succinate dehydrogenase complex in Bursaphelenchus xylophilus. International Journal of Molecular Sciences 25(13):6914. doi: 10.3390/ijms25136914
  20. Loehle, C., Miller, D. A., Kovach, A. I., Larsen-gray, A. L., Akresh, M. E., McDonald, J. E., Cheeseman, A. E., King, D., Petzinger, S. M., and Kanter, J. 2024. Forest management is key for conserving biodiversity and providing ecosystem services in the United States. Forests 15:2087. doi: 10.3390/f15122087
  21. Loyd, A. L., Borden, M. A., Littlejohn, C. A., Rigsby, C. M., Brantley, B., Ware, M., McCurry, C., and Fite, K. 2025. Thiabendazole as a therapeutic root flare injection for beech leaf disease management. Arboriculture and Urban Forestry 51(3):215–225. doi: 10.48044/jauf.2025.007
  22. Loyd, A. L., Cowles, R. S., Borden, M. A., LaMondia, J. A., Mitkowski, N., Faubert, H., Burke, D., Hausman, C., Volk, D., Littlejohn, C., Stiller, A., Rigsby, C. M., Brantley, B., and Fite, K. 2024. Exploring novel management methods for beech leaf disease, an emerging threat to forests and landscapes. Journal of Environmental Horticulture 42(1):1–13. doi: 10.24266/0738-2898-42.1.1
  23. Marra, R. E. 2023. Beech Leaf Disease: and the Newly Described Nematode That Causes It. University of Massachusetts Extension, Invasive Insect Webinar Series. Accessed 09-19-2025: https://www.umass.edu/agriculture-food-environment/landscape/videos/umass-extensions-2023-invasive-insect-webinar-series-day-3-beech-leaf-disease-nematode-invasive
  24. McIntire, C. D. 2023. Physiological impacts of beech leaf disease across a gradient of symptom severity among understory American beech. Frontiers in Forests and Global Change 6:1–9. doi: 10.3389/ffgc.2023.1146742
  25. Oka, Y. 2020. From old-generation to next-generation nematicides. Agronomy 10(9):1387. doi: 10.3390/agronomy10091387
  26. Popkin, G. 2023. Could one of our most important trees disappear with barely a whimper? The Nature Beat. https://gabepopkin.substack.com/p/could-one-of-our-most-important-trees
  27. Reed, S. E., Greifenhagen, S., Yu, Q., Hoke, A., Burke, D. J., Carta, L. K., Handoo, Z. A., Kantor, M. R., and Koch, J. 2020. Foliar nematode, Litylenchus crenatae ssp. mccannii, population dynamics in leaves and buds of beech leaf disease-affected trees in Canada and the US. Forest Pathology 50(3):1–9. doi: 10.1111/efp.12599
  28. Schleker, A. S. S., Rist, M., Matera, C., Damijonaitis, A., Collienne, U., Matsuoka, K., Habash, S. S., Twelker, K., Gutbrod, O., Saalwächter, C., Windau, M., Matthiesen, S., Stefanovska, T., Scharwey, M., Marx, M. T., Geibel, S., and Grundler, F. M. W. 2022. Mode of action of fluopyram in plant-parasitic nematodes. Scientific Reports 12(1):1–14. doi: 10.1038/s41598-022-15782-7
  29. Shepherd, B. L., Burke, D. J., and Stuble, K. L. 2025. Fagus grandifolia growth and mortality a decade after the emergence of beech leaf disease. Trees, Forests and People 20:100836. doi: 10.1016/j.tfp.2025.100836
  30. Vieira, P., Kantor, M. R., Jansen, A., Handoo, Z. A., and Eisenback, J. D. 2023. Cellular insights of beech leaf disease reveal abnormal ectopic cell division of symptomatic interveinal leaf areas. Plos ONE 18(10):e0292588. doi: 10.1371/journal.pone.0292588
  31. Volk, D., and Martin, D. 2023. Beech leaf disease distribution. Cleveland Metroparks. https://www.clevelandmetroparks.com/parks/education/education-resources/publications
  32. Waldo, B. D., Grabau, Z. J., Mengistu, T. M., and Crow, W. T. 2019. Nematicide effects on non-target nematodes in bermudagrass. Journal of Nematology 51(1):1–12. doi: 10.21307/jofnem-2019-009
  33. Wolf, E., and Vieira, P. 2024. Rapid assessment of beech leaf disease in Fagus sylvatica buds. Forest Pathology 54(2):1–22. doi: 10.1111/efp.12858
DOI: https://doi.org/10.2478/jofnem-2025-0042 | Journal eISSN: 2640-396X | Journal ISSN: 0022-300X
Language: English
Submitted on: May 20, 2025
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Published on: Oct 5, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Matthew A. Borden, Paulo Vieira, Caitlin Littlejohn, Jacob Zack, Michael Sherwood, Amber Stiller, Kelby Fite, Andrew L. Loyd, published by Society of Nematologists, Inc.
This work is licensed under the Creative Commons Attribution 4.0 License.