Abstract
Background
Haemophilia is an inherited bleeding disorder requiring regular factor replacement therapy, often necessitating frequent hospital visits. Home therapy (HT) has emerged as a viable alternative, improving patient independence and adherence. This study evaluates the impact of a structured home therapy intervention at Assam Medical College and Hospital on treatment adherence, self-infusion rates, and quality of life among haemophilia patients.
Methods
This was a prospective interventional study conducted over from January 2023 to January 2024, involving 29 people with haemophilia (PWH). Participants underwent structured self-infusion training, nurse-led home visits, and education on prophylactic therapy. Data was collected at three time points (pre-HT, mid-HT, and post-HT) using standardised surveys assessing adherence, self-infusion rates, quality of life, and patient satisfaction. Statistical analyses included paired t-tests and McNemar's test for pre-post comparisons.
Results
The study observed a 75% adoption of self-infusion, up from 38% at baseline. Prophylactic therapy uptake increased by 56%, while adherence to twice-weekly dosing improved from 76% to 83%. Patients reported 93% improvement in mobility and 82% reduction in joint pain and bleeding episodes. Dependence on healthcare providers decreased by 55%, as more patients transitioned to self-administration. The overall satisfaction score was 99%, reflecting high acceptance of the intervention.
Conclusion
Structured home therapy significantly improved treatment adherence, self-infusion practices, and patient independence, reducing the burden on healthcare providers. The findings support home-based models as a scalable approach for managing haemophilia in resource-limited settings. Future studies should explore multicentre validation and integration of telehealth solutions to sustain these benefits.