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Warburg effect in B-cell lymphoma: A case report and proposed management plan Cover

Warburg effect in B-cell lymphoma: A case report and proposed management plan

Open Access
|Jan 2026

References

  1. Pascale RM, Calvisi DF, Simile MM, Feo CF, Feo F. The Warburg Effect 97 Years after Its Discovery. Cancers (Basel). 2020;12(10).
  2. Warburg O. The metabolism of carcinoma cells. The Journal of Cancer Research. 1925;9(1):148–63.
  3. Warburg O, Minami S. Versuche an überlebendem carcinom-gewebe. Klinische Wochenschrift. 1923;2(17):776–7.
  4. Vaupel P, Multhoff G. Revisiting the Warburg effect: historical dogma versus current understanding. J Physiol. 2021;599(6):1745–57.
  5. Koppenol WH, Bounds PL, Dang CV. Otto Warburg’s contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325–37.
  6. Bar-Or D, Carrick M, Tanner A, 2nd, Lieser MJ, Rael LT, Brody E. Overcoming the Warburg Effect: Is it the key to survival in sepsis? J Crit Care. 2018;43:197–201.
  7. Chaba A, Fodil S, Lemiale V, et al. Clinical Warburg effect in lymphoma patients admitted to intensive care unit. Ann Intensive Care. 2023;13(1):97.
  8. Zhou Z, Sehn LH, Rademaker AW, et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123(6):837–42.
  9. Singer P, Blaser AR, Berger MM, et al. ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit. Clin Nutr. 2023;42(9):1671–89.
  10. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309–19.
  11. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–33.
  12. Ruiz JP, Singh AK, Hart P. Type B lactic acidosis secondary to malignancy: case report, review of published cases, insights into pathogenesis, and prospects for therapy. ScientificWorldJournal. 2011;11:1316–24.
  13. DeBerardinis RJ, Chandel NS. Fundamentals of cancer metabolism. Sci Adv. 2016;2(5):e1600200.
  14. Bays DJ, Thompson GR, 3rd. Fungal Infections of the Stem Cell Transplant Recipient and Hematologic Malignancy Patients. Infect Dis Clin North Am. 2019;33(2):545–66.
  15. Jimenez JV, Carrillo-Perez DL, Rosado-Canto R, et al. Electrolyte and Acid-Base Disturbances in End-Stage Liver Disease: A Physiopathological Approach. Dig Dis Sci. 2017;62(8):1855–71.
  16. Burke MD. Liver function: test selection and interpretation of results. Clin Lab Med. 2002;22(2):377–90.
  17. Nair R, Shah U. Lactic Acidosis: A Rare Oncological Emergency in Solid Tumors at Presentation. Am J Med Sci. 2017;353(4):402–6.
  18. Sillos EM, Shenep JL, Burghen GA, Pui CH, Behm FG, Sandlund JT. Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature. Cancer. 2001;92(9):2237–46.
  19. Cao Y, Liu MC, Hanlon EL, et al. Clinical presentation of Warburg effect in aggressive lymphoma: a case report. J Med Case Rep. 2023;17(1):380.
  20. Al Maqrashi Z, Sedarous M, Pandey A, Ross C, Wyne A. Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect. Case Rep Oncol. 2021;14(2):1159–67.
  21. Swenson ER. Hypoxia and Its Acid-Base Consequences: From Mountains to Malignancy. Adv Exp Med Biol. 2016;903:301–23.
  22. Fraley DS, Adler S, Bruns FJ, Zett B. Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactic acidosis. N Engl J Med. 1980;303(19):1100–2.
  23. Griffin D, Myadam R, Patel P. Steroid-induced Lactic Acidosis in Diffuse Large B-cell Lymphoma. Cureus. 2020;12(3):e7446.
DOI: https://doi.org/10.2478/jccm-2025-0045 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 135 - 140
Submitted on: Apr 30, 2025
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Accepted on: Sep 30, 2025
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Published on: Jan 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Stefan Gligor, Salim Abdelhamid, Veronika Ballova, Andrea Kopp Lugli, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.