Skip to main content
Have a personal or library account? Click to login
Treatment Patterns and Long-Term Survival Outcomes in Muscle-Invasive Bladder Cancer: A Decade-Long Single-Institution Retrospective Cohort Study Cover

Treatment Patterns and Long-Term Survival Outcomes in Muscle-Invasive Bladder Cancer: A Decade-Long Single-Institution Retrospective Cohort Study

Open Access
|Sep 2026

References

  1. Witjes JA, Bruins HM, Cathomas R. European Association of Urology Guidelines on Muscle-Invasive and Metastatic Bladder Cancer: Summary of the 2021 Guidelines. European Urology. 2021;79(1):82–104.
  2. Galsky MD, Stensland KD, Sfakianos JP. Comparative effectiveness of treatment strategies for muscle invasive bladder cancer. Lancet. 2020;395(10221):554–64.
  3. Flaig TW, Spiess PE, Agarwal N. NCCN Guidelines Insights: Bladder Cancer, Version 2.2020. Journal of the National Comprehensive Cancer Network. 2020;18(3):329–54. doi:10.6004/jnccn.2020.0017
  4. Grossman HB, Natale RB, Tangen CM, Speights V, Vogelzang NJ, Trump DL, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. New England Journal of Medicine. 2003;349(9):859–66.
  5. Seisen T, Sun M, Lipsitz SR, Abdollah F, Leow JJ, Menon M, et al. Comparative effectiveness of trimodal therapy versus radical cystectomy for localized muscle-invasive urothelial carcinoma of the bladder. European urology. 2017;72(4):483–7.
  6. Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, et al. Neoadjuvant chemotherapy for muscle-invasive bladder cancer: a systematic review and two-step meta-analysis. The oncologist. 2016;21(6):708–15.
  7. Zargar-Shoshtari K, Zargar H, Lotan Y, Shah JB, van Rhijn BW, Daneshmand S, et al. A multi-institutional analysis of outcomes of patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy followed by cystectomy. Journal of Clinical Oncology. 2016;34(17):1934–40.
  8. Dash A, Pettus IV JA, Herr HW, Bochner BH, Dalbagni G, Donat SM, et al. A role for neoadjuvant gemcitabine plus cisplatin in muscle-invasive urothelial carcinoma of the bladder: a retrospective experience. Cancer. 2008;113(9):2471–7.
  9. James ND, Hussain SA, Hall E, Jenkins P, Tremlett J, Rawlings C, et al. Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. New England Journal of Medicine. 2012;366(16):1477–88.
  10. James ND, Hussain SA, Hall E, Jenkins P, Tremlett J, Rawlings C, et al. Long-term outcomes of radiotherapy with or without chemotherapy for muscle invasive bladder cancer: ten-year follow-up of the BC2001 trial. Journal of Clinical Oncology. 2022;40(4):384–94. doi:10.1200/JCO.21.01506
  11. Mak RH, Hunt D, Shipley WU, Efstathiou JA, Tester WJ, Hagan MP, et al. Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233. Journal of Clinical Oncology. 2014;32(34):3801–9.
  12. Giacalone NJ, Shipley WU, Clayman RH, Niemierko A, Drumm M, Heney NM, et al. Long-term outcomes after bladder-preserving tri-modality therapy for patients with muscle-invasive bladder cancer: an updated analysis of the Massachusetts General Hospital experience. European urology. 2017;71(6):952–60.
  13. Hamad J, McCloskey H, Milowsky MI, Royce T, Smith A. Bladder preservation in muscle-invasive bladder cancer: a comprehensive review. International braz j urol. 2020;46(2):169–84.
  14. Gupta S, Hensley PJ, Li R, Choudhury A, Daneshmand S, Faltas BM, et al. Bladder preservation strategies in muscle-invasive bladder cancer: recommendations from the International Bladder Cancer Group. European urology. 2025.
  15. Moschini M, Shariat SF, Rouprêt M, et al. Impact of surgical delay on outcomes in patients with muscle invasive bladder cancer. European Urology Focus. 2021;7(1):89–97.
  16. Vetterlein MW, Gild P, Kluth LA, Soave A, Dahlem R, Fisch M, et al. Conditional survival of patients with muscle invasive bladder cancer. European Urology. 2020;77(4):553–61. doi:10.1016/j.eururo.2019.11.019
Language: English
Page range: 122 - 128
Published on: Sep 10, 2026
Published by: Shakuat Khanum Memorial Cancer Hospital and Research Centre
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Fajar Rafi Ranjha, Asma Rashid, Abdullah Adnan, Muhammad Kashif, Ikrama Tanveer, Tabinda Sadaf, Zile-Huma Hashmi, Amna Munawar, published by Shakuat Khanum Memorial Cancer Hospital and Research Centre
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.