Role of Preoperative Tapentadol in Reduction of Peri-operative Analgesics Requirements After Breast Conservative Surgery in Cancer Patients: A Randomized Controlled Trial
References
- Ramirez MF, Strang A, Roland G, Lasala J, Owusu-Agyemang P. Perioperative pain management and cancer outcomes: a narrative review. J Pain Res. 2023;16:4181–89.
- Hill BL, Lefkowits C. Strategies for optimizing perioperative pain management for the cancer patient. Surg Oncol Clin N Am. 2021;30(3):519–34.
- Heldreich C, Meyer I, Dube E, Hu R, Howard W, Holmes N, Maroon N, Weinberg L, Tan CO. Peri-Operative Pain Management, Education and De-escalation (POPPMED), a novel anaesthesiologist-led program, significantly reduces acute and long-term postoperative opioid requirements: a retrospective cohort study. Pain Reports. 2022 Sep 1;7(5):e1028.
- Krtinic D, Nedin Rankovic G, Petkovic I, Cvetanovic A, Conic I, Todorovic Mitic M, et al. The role of tapentadol in cancer pain pharmacotherapy in patients with metastatic malignant disease. Eur Rev Med Pharmacol Sci. 2023;27:12112–20.
- Takahara Y, Tanahashi J, Murota K, Imai M, Takagi Y, Kimata T. Efficacy of Tapentadol for Neuropathic Pain in Cancer. Gan To Kagaku Ryoho. 2021;48:811–4.
- Wang X, Narayan SW, Penm J, Patanwala AE. Efficacy and safety of tapentadol immediate release for acute pain: a systematic review and meta-analysis. Clin J Pain. 2020;36(5):399–409.
- Viscusi ER, Allard R, Sohns M, Eerdekens M. Tapentadol immediate release for moderate to severe acute post-surgery pain. J Opioid Manag. 2019;15(1):51–67.
- Pujol J, Martínez-Vilavella G, Doreste A, Blanco-Hinojo L, Ojeda F, Llorente-Onaindia J, et al. Tapentadol effects on brain response to pain in sensitized patients with knee osteoarthritis. Rheumatology (Oxford). 2022;61(6):2335–45.
- Alshehri FS. Tapentadol: a review of experimental pharmacology studies, clinical trials, and recent findings. Drug Des Devel Ther. 2023;17:851–61.
- Eissa A, Tarau E, Beuter C, Radic T, Watson E, Sohns M, et al. Tapentadol for the treatment of moderate-to-severe acute pain in children under the age of two years. J Pain Res. 2021;14:229–48.
- Yadav G, Jain G, Samprathi A, Baghel A, Singh DK. Role of preventive tapentadol in reduction of perioperative analgesic requirements after laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol. 2016;32(4):492–6.
- Kulkarni VR, Sancheti R. A comparative study of effect of oral tapentadol versus oral gabapentin for postoperative pain relief in adult patients undergoing abdominal surgeries under general anaesthesia. MedPulse International Journal of Anesthesiology. January 2020; 13(1): 01–06
- Buynak R, Shapiro DY, Okamoto A, Van Hove I, Rauschkolb C, Steup A, Lange B, Lange C, Etropolski M. Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo and active controlled phase III study. Expert Opin Pharmacother. 2010;11:1787–804.
- Gupta A, Singh A, Ranjan P. Role of pre-emptive tapentadol in reduction of postoperative analgesic requirements after cholecystectomy. Int J Acad Med Pharm 2023;5(2):1631–36.
- Safneedha PM, Raveena Ragavi CGV, Pughal Vendan G. To assess the role of nasal tapentadol as pre-emptive analgesia, in breast surgery patients. Int J Res Pharm Sci. 2024;15(3): 92–9.
- Vadivelu N, Huang Y, Mirante B, Jacoby M, Braveman FR, Hines RL, et al. Patient considerations in the use of tapentadol for moderate to severe pain. Drug Healthc Patient Saf. 2013;3:151–9.
- Hartrick CT, Rodríguez Hernandez JR. Tapentadol for pain: a treatment evaluation. Expert Opin Pharmacother. 2012;13(2): 283–6.
- Kleinert R, Lange C, Steup A, Black P, Goldberg J, Desjardins P. Single dose analgesic efficacy of tapentadol in postsurgical dental pain: the results of a randomized, double-blind, placebo-controlled study. Anesth Analg. 2008 Dec 1;107(6):2048–55.
- Hartrick C, Van Hove I, Stegmann JU, Oh C, Upmalis D. Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study. Clin Ther. 2009;31:260–71.
- Santos J, Alarcão J, Fareleira F, Vaz-Carneiro A, Costa J. Tapentadol for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2015;5:CD009923.
- Raffa RB, Elling C, Tzschentke TM. Does ‘strong analgesic’ equal ‘strong opioid’? Tapentadol and the concept of ‘μ load’. Adv Ther. 2018;35:1471–84.
- Baron R, Eberhart L, Kern KU. Tapentadol prolonged release for chronic pain: a review of clinical trials and 5 years of routine clinical practice data. Pain Pract. 2017;17:678–700.
DOI: https://doi.org/10.2478/jcas-2026-0012 | Journal eISSN: 2411-989X
Language: English
Page range: 78 - 84
Published on: Jun 29, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
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© 2026 Yusra Saleem, Allah Ditta Ashfaq, Syed Raza Mehdi, Asad Aleem, published by Shakuat Khanum Memorial Cancer Hospital and Research Centre
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.