Figure 1.
Figure 2.
Figure 3.
Baseline demographic and perioperative characteristics of study participants (Group A = Tapentadol, Group B= Placebo)_
| Group A (n=35) | Group B (n=35) | p Value | |
|---|---|---|---|
| Age, years;mean(SD) | 40.97±9.10 | 45.83±10.93 | 0.041 |
| BMI, kg/m2;mean(SD) | 25.96±3.43 | 26.75±4.73 | 0.426 |
| ASA 2;n(%) | 34(97.1%) | 35(100%) | 0.314 |
| Duration of surgery, minutes;mean(SD) | 64.57±24.86 | 64.69±24.05 | 0.984 |
Comparison of intraoperative morphine consumption and time to first rescue analgesia between Group A: Tapentadol and Group B: Placebo_
| Group A (n=35) Mean ± SD | Group B (n=35) Mean ± SD | Mean Difference | 95%CI | p-value | |
|---|---|---|---|---|---|
| Intra-operative morphine consumption(mg) | 1.11 ± 1.53 | 3.36 ± 1.60 | −2.24 | −2.99 to −1.49 | <0.001 |
| Time to first rescue analgesia postoperatively(minutes) | 58.0 ± 21.7 | 43.5 ± 27.3 | 14.5 | −14.4 to 43.4 | 0.290 |
Postoperative pain scores measured by Numerical Rating Scale (NRS) at predefined time intervals following surgery (Group A = Tapentadol, Group B= Placebo)_
| Time intervals (hours) | Pain score, Group A (n=35) Mean ± SD | Pain Score, Group B (n=35) Mean ± SD | Mean Difference in Pain scores. | 95%CI | p-value |
|---|---|---|---|---|---|
| 1 | 1.89 ± 0.83 | 2.46 ± 1.15 | −0.571 | −1.050 to −0.093 | 0.020 |
| 2 | 1.31 ± 0.63 | 1.66 ± 0.87 | −0.343 | −0.707 to 0.021 | 0.064 |
| 3 | 1.06 ± 0.24 | 1.23 ± 0.43 | −0.171 | −0.336 to −0.006 | 0.042 |
| 4 | 1.00 ± 0.00 | 1.03 ± 0.17 | −0.029 | −0.087 to 0.029 | 0.324 |
Comparison between number of patients requiring rescue analgesia in each group_ Group A: Tapentadol and Group B: Placebo_
| Group A (n=35) Frequency (%) | Group B (n=35) Frequency (%) | p-value | |
|---|---|---|---|
| Intra-operative | 13 (37.1) | 31 (88.6) | <0.001 |
| Post-operative | 5 (14.3) | 10 (28.6) | 0.145 |