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GLDS-248 Experimental Groups_
| Live Animal Return (LAR or FLT LAR) | ISS Terminal (ISS-T or FLT ISS-T) |
|---|---|
| Returned to Earth and euthanized after 29 days on the ISS. | Euthanized on the ISS Terminal after 50 or more days on the ISS. |
| LAR Baseline | ISS-T Baseline |
| 36-week-old mice were euthanized to emulate data of the mice before spaceflight. | 36-week-old mice were euthanized to emulate data of the mice before spaceflight. |
| GC LAR | GC ISS-T |
| Housed on Earth and euthanized at the same time as LAR mice. | Housed on Earth and euthanized at the same time as ISS-T mice. |
Differentially Expressed Genes of Interest_
| Group Comparison | Gene ID | Gene Name | Log2 FC | Adj p-value |
|---|---|---|---|---|
| GC ISS-T vs FLT ISS-T | Arntl | Aryl hydrocarbon receptor nuclear translocator-like | 1.798 | 1.1E-08 |
| Arsj | Arylsulfatase J | 1.078 | 2.5E-05 | |
| Bhlhe41 | Basic helix-loop-helix family, member e41 | −1.323 | 5.5E-08 | |
| Ccnjl | Cyclin J-like | 1.714 | 2.1E-06 | |
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21) | 1.285 | 1.5E-02 | |
| Cyp26b1 | Cytochrome P450, family 26, subfamily b, polypeptide 1 | 2.283 | 4.4E-12 | |
| Fam124b | Family with sequence similarity 124, member B | 2.967 | 3.4E-18 | |
| Hlf | Hepatic leukemia factor | −1.436 | 1.3E-05 | |
| Npas2 | Neuronal PAS domain protein 2 | 1.856 | 2.3E-06 | |
| Per2 | Period circadian clock 2 | −1.483 | 1.4E-03 | |
| Per3 | Period circadian clock 3 | −1.263 | 1.8E-07 | |