Have a personal or library account? Click to login
Role of alpha and gamma Klotho genes in the development of differentiated thyroid carcinoma on top of goiter Cover

Role of alpha and gamma Klotho genes in the development of differentiated thyroid carcinoma on top of goiter

Open Access
|Sep 2023

References

  1. Gallardo E, Medina J, Sánchez JC, Viudez A, Grande E, Porras I, et al. SEOM clinical guideline thyroid cancer (2019). Clin. Transl. Oncol. 2020;22(2):223–235. https://doi.org/10.1007/s12094-019-02284-8
  2. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA. Cancer. J. Clin. 2022;72(1):7–33. https://doi.org/10.3322/caac.21708
  3. El-Gammal Hammed ER, El-Azonny MM, Al-Shamy AT. ROLE OF LEVEL V LYMPH NODE DISSECTION IN N1b PAPILLARY THYROID CARCINOMA. Al-Azhar. Med. J. 2019;48(4):421–434. https://doi:10.21608/amj.2019.64949
  4. Dal Maso L, Tavilla A, Pacini F, Serraino D, van Dijk BAC, Chirlaque MD, et al. Survival of 86,690 patients with thyroid cancer: a population-based study in 29 European countries from EUROCARE-5. Eur. J. Cancer. 2017;77:140–152. https://doi.org/10.1016/j.ejca.2017.02.023
  5. Sanabria A, Kowalski LP, Shah JP, Nixon IJ, Angelos P, Williams MD, et al. Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis. Head. Neck. 2018;40(4):855–866. https://doi.org/10.1002/hed.25029
  6. Katoh H, Yamashita K, Enomoto T, Watanabe M. Classification and general considerations of thyroid cancer. Ann. Clin. Pathol. 2015;3(1):1045.
  7. Giordano TJ. Genomic Hallmarks of Thyroid Neoplasia. Annu. Rev. Pathol.: Mechanisms of Disease. 2018;13(1):141–162. https://doi.org/10.1146/annurev-pathol-121808-102139
  8. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390(1):45–51. https://doi.org/10.1038/36285
  9. Wang Y, Sun Z. Current understanding of klotho. Ageing. Res. Rev. 2009;8(1):43–51. https://doi.org/10.1016/j.arr.2008.10.002
  10. Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim. Biophys. Acta. 2002;1576(3):341–345. https://doi.org/10.1016/s0167-4781(02)00281-6
  11. Hori S, Miyake M, Tatsumi Y, Morizawa Y, Nakai Y, Onishi S, et al. Gamma-Klotho exhibits multiple roles in tumor growth of human bladder cancer. Oncotarget. 2018;9(28):19508–19524. https://doi.org/10.18632/oncotarget.24628
  12. Kurosu H, Kuro-o M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol. Cell. Endocrinol. 2009;299(1):72–78. https://doi.org/10.1016/j.mce.2008.10.052
  13. Xie B, Chen J, Liu B, Zhan J. Klotho Acts as a Tumor Suppressor in Cancers. Pathol. Oncol. Res. 2013;19(4):611–617. https://doi.org/10.1007/s12253-013-9663-8
  14. Peshes-Yeloz N, Ungar L, Wohl A, Jacoby E, Fisher T, Leitner M, et al. Role of Klotho protein in tumorigenesis, cancer progression, and prognosis in patients with high-grade glioma. World. Neurosurg. 2019;130:e324–e332. https://doi.org/10.1016/j.wneu.2019.06.082
  15. Chen B, Liang Y, Chen L, Wei Y, Li Y, Zhao W, et al. Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells. J. Cancer. 2018;9(7):1248–1258. https://doi.org/10.7150/jca.23967
  16. Trošt N, Peña-Llopis S, Koirala S, Stojan J, Potts PR, Tacer KF, et al. γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget. 2016;7(3):2611–2628. https://doi.org/10.18632/oncotarget.6006
  17. Anderson CE, Mclaren KM. Best Practice No 171: Best practice in thyroid pathology. J. Clin. Pathol. 2003;56(6):401–405. http://dx.doi.org/10.1136/jcp.56.6.401
  18. Chomczynski P, Sacchi N. The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on. Nat. protoc. 2006;1(2):581–585. https://doi.org/10.1038/nprot.2006.83
  19. Freeman WM, Walker SJ, Vrana KE. Quantitative RT-PCR: pitfalls and potential. Biotechniques. 1999;26(1):112–125. https://doi.org/10.2144/99261rv01
  20. Zhang M, Zhao J, Tang W, Wang Y, Peng P, Li L, et al. High Hepsin expression predicts poor prognosis in Gastric Cancer. Sci. Rep. 2016;6(1):1–10. https://doi.org/10.1038/srep36902
  21. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2001;25(4):402–408. https://doi.org/10.1006/meth.2001.1262
  22. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin. Chem. 1993;39(4):561–577. https://doi.org/10.1093/clinchem/39.4.561
  23. Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene. 2008;27(56):7094–7105. https://doi.org/10.1038/onc.2008.292
  24. Rubinek T, Wolf I. The Role of Alpha-Klotho as a Universal Tumor Suppressor. Vitam. Horm. 2016;101:197–214. https://doi.org/10.1016/bs.vh.2016.03.001
  25. Arbel Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson TE, et al. A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy. Cancers (Basel). 2021;13(24):6297. https://doi.org/10.3390/cancers13246297
  26. Huang S, Wang W, Cheng Y, Lin J, Wang M. Clinicopathological and prognostic significance of klotho and estrogen receptors expression in human hepatocellular carcinoma. Turk. J. Gastroenterol. 2021;32(10):828–836. https://doi.org/10.5152/tjg.2021.19986
  27. Lu L, Katsaros D, Wiley A, Rigault de la Longrais IA, Puopolo M, Yu H. Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression. Cancer. Invest. 2008;26(2):185–192. https://doi.org/10.1080/07357900701638343
  28. Pawlikowski M, Pisarek H, Borkowska M, Winczyk K. Expression of α-Klotho protein in human thyroid cancers—an immunohistochemical study. Endokrynol. Pol. 2019;70(3):237–240. https://doi.org/10.5603/EP.a2019.0004
  29. Dai D, Wang Q, Li X, Liu J, Ma X, Xu W. Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1. Oncol. Rep. 2016;35(1):552–558. https://doi.org/10.3892/or.2015.4358
  30. Wu Q, Jiang L, Wu J, Dong H, Zhao Y. Klotho Inhibits Proliferation in a RET Fusion Model of Papillary Thyroid Cancer by Regulating the Wnt/β-Catenin Pathway. Cancer. Manag. Res. 2021;13:4791–4802. https://doi.org/10.2147/CMAR.S295086
  31. Saran S. Multinodular goiter. In: Agrawal NK, editor. Goiter-Causes and Treatment. London: IntechOpen; 2020. p. 99–110. http://dx.doi.org/10.5772/intechopen.90325
  32. Hammad MO, Elabbasy LM, Abd Elghaffar MA, Zaki MM, Bazeed FB, Zahran MA. Significance of CEP78 and WDR62 gene expressions in differentiated thyroid carcinoma: Possible predictors of lateral lymph node metastasis. Asia. Pac. J. Clin. Oncol. 2019;15(5):e154–e161. https://doi.org/10.1111/ajco.13143
  33. Xu X, Hao Y, Zhong Q, Hang J, Zhao Y, Qiao J. Low KLOTHO level related to aging is associated with diminished ovarian reserve. Fertil. Steril. 2020;114(6):1250–1255. https://doi.org/10.1016/j.fertnstert.2020.06.035
  34. Lee HJ, Choi JY, Lee J, Kim D, Min JY, Min KB. Association between serum uric acid and α-klotho protein levels in the middle-aged population. Aging (Albany NY). 2022;14(6):2537–2547. https://doi.org/10.18632/aging.203987
  35. Li Y, Xiao HJ, Xue F. Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo. Genet. Mol. Biol. 2020;43(2):e20190229. https://doi.org/10.1590/1678-4685-GMB-2019-0229
  36. Zhou X, Fang X, Jiang Y, Geng L, Li X, Li Y, et al. Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma. J. Hematol. Oncol. 2017;10(1):1–1. https://doi.org/10.1186/s13045-017-0391-5
  37. Onishi K, Miyake M, Hori S, Onishi S, Lida K, Morizawa Y, et al. γ-Klotho is correlated with resistance to docetaxel in castration-resistant prostate cancer. Oncol. Lett. 2020;19(3):2306–2316. https://doi.org/10.3892/ol.2020.11308
  38. Su J, Ma Q, Long W, Tang H, Wu C, Luo M, et al. LCTL is a prognostic biomarker and correlates with stromal and immune infiltration in gliomas. Front. Oncol. 2019;9:1083 https://doi.org/10.3389/fonc.2019.01083
DOI: https://doi.org/10.2478/fco-2023-0006 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
Language: English
Page range: 31 - 39
Submitted on: Dec 15, 2022
Accepted on: Jul 25, 2023
Published on: Sep 15, 2023
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2023 Wesam S. El-Saeed, Marwa H. Elnagdy, Mahmoud A. Abd elghaffar, Ayman El Baz, Mohammed A. Zahran, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.