History of food intolerance and other allergic reactions
| Patients n (%) | Healthy subjects n (%) | P | |
|---|---|---|---|
| Food intolerance | 10 (7.3) | 6 (12.2) | |
| History of food-related allergic reactions: | 21 (15.4) | 4 (8.2) | |
| • Angioedema | 6 (4.4) | 2 (4.1) | |
| • Urticaria | 15 (11.,0) | 2 (4.1) | |
| • Both A/U | 5 (3.7) | 0 (0) | |
| Atopic status | 43 (31.6) | 4 (8.2) | 0.001 |
| Anaphylactic shock | 5 (3.7) | 3 (6.1) | |
| Eczema | 27 (19.7) | 4 (8.2) | |
| Allergic asthma | 19 (14.0) | 1 (2.0) | 0.028 |
| Allergic rhinitis | 42 (30.9) | 6 (12.2) | 0.0128 |
| Contact dermatitis | 30 (22.1) | 7 (14.4) | |
| Family history of allergic symptoms | 37 (27.0) | 11 (22.4) |
Lifestyle habits concerning smoke, alcohol and coffee
| Patients n (%) | Healthy subjects n (%) | |
|---|---|---|
| Smokers | 34 (25.0) | 10 (20.4) |
| <10 cigaretes/die | 11 ( 8.0) | 3 (6.1) |
| >10 cigarettes/die | 23 (16.9) | 7 (14.3) |
| Alcohol consumers | 39 (28.7) | 12 (24.5) |
| Coffee consumers | 85 (62.5.) | 34 (69.4) |
| <3 cofee/die | 27 (19.8) | 6 (12.3) |
| >3 cofee/die | 58 (42.6) | 28 (57.1) |
Other common gastrointestinal symptoms reported by Group 1 patients
| Others GI symptoms | N° of patients (Group 1) 68 pz (95,7%) |
|---|---|
| • Regurgitation | 26 (36.6 %) |
| • Digestive alterations | 17 (23.9%) |
| • Irritable Bowel Syndrome | 19 (26.8%) |
| • Others | 6 (8.4%) |
Distribution of symptoms and other modifications in the two Groups
| Patients (%) | Healthy subjects (%) | P | |
|---|---|---|---|
| Acute Abdomen | 28 (20.6) | 1 (2.0) | 0.0011 |
| Rheumatologic manifestations | 37 (2.2) | 4 (8.2) | 0.0049 |
| Eosinophilia | 5 (3.7) | 0 | |
| GI symptoms | 71 (52.2) | 1 (2.0) | <0.0001 |
Consumption of poorly or no cooked fish
| Patients (%) | Healthy subjects (%) | P | OR (95%CI) | |
|---|---|---|---|---|
| Total poorly cooked fish consumers | 118 (86.8) | 32 (6.3) | 0.0023 | 3.48 (1.61-7.52) |
| Raw fish | 33 (24.2) | 14 (28.6) | 0.80 (0.38-1.67) | |
| Smoked fish | 98 (72.1) | 16 (32.0) | <0.0001 | 5.32 (2.63-10.76) |
| Dry salted/pickled fish | 91 (67.1) | 13 (26.5) | <0.0001 | 5.60 (2.70-11.59) |
| Raw shellfish | 33 (24) | 6 (12.2) | 2.29 (0.89-5.88) | |
| 2 among the above | 21 (15.4) | 9 (18.4) | - | |
| 3 among the above | 14 (12.3) | 4 (8.2) | - | |
| 4 among the above | 17 (10.0) | 1 (2.0) | 0.0457 | 6.85 (0.88-52.97) |
Positive patients to Anisakis sensitization
| Patient (n°) | Raw fish consumption | GI symptoms | Allergic symptoms | Others | Food intolerance | Specific IgE KUA/L |
|---|---|---|---|---|---|---|
| Group 1 A | All 4 types | Pyrosis, Retrosternal pain, digestive alterations | None | Rheumatologic manifestations | No | 13.8 |
| Group 1 B | Dry salted fish | None | None | Polyp removal | No | 0.98 |
| Group 1 C | Dry salted fish | Pyrosis | Angioedema, Urticaria, Eczema | Eosinophilia, family history of allergic reactions | No | 0.88 |
| Group 2 C1 | Raw and smoked fish | None | None | None | No | 0.51 |
| Group 2 C2 | Smoked fish | None | None | None | No | 1.57 |