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Smoking May Impact IL-33/ST2 Signaling for Better Cognitive Functioning in Schizophrenia Cover

Smoking May Impact IL-33/ST2 Signaling for Better Cognitive Functioning in Schizophrenia

Open Access
|Jun 2026

References

  1. Cayrol C, Girard JP. Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev. 2018; 281 (1):154–68.
  2. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23 (5):479–90.
  3. Miller AM. Role of IL-33 in inflammation and disease. J Inflamm (Lond). 2011; 8 (1):22.
  4. Guo H, Bossila EA, Ma X, Zhao C, Zhao Y. Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions. Cells. 2022; 11 (20):3237.
  5. Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, et al. Production and functions of IL-33 in the central nervous system. Brain Res. 2011; 1385:8–17.
  6. Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, et al. Neuroinflammation Induces Neurodegeneration. J Neurol Neurosurg Spine. 2016; 1 (1):1003.
  7. Wicher G, Husic E, Nilsson G, Forsberg-Nilsson K. Developmental expression of IL-33 in the mouse brain. Neurosci Lett. 2013; 555:171–6.
  8. Reverchon F, de Concini V, Larrigaldie V, Benmerzoug S, Briault S, Togbé D, et al. Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments. J Neuroinflammation. 2020; 17 (1):268.
  9. Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Küchler AM. Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol. 2009; 30 (5):227–33.
  10. Li Q, Zhao Y, Shi C, Song X. IL-33 Alleviates Postoperative Cognitive Impairment by Inhibiting Hippocampal Inflammation and Upregulating Excitatory Synaptic Number in Aged Mice. Brain Sci. 2022; 12 (9):1244.
  11. Borovcanin MM, Janicijevic SM, Jovanovic IP, Gajovic N, Arsenijevic NN, Lukic ML. IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis. Front Psychiatry. 2018; 9:271.
  12. Минић Јанићијевић Славица, Minić Janićijević S. Утицај IL-33/ST2 сигналног пута и галектина-3 на клиничке карактеристике пацијената са схизофренијом у ремисији:докторска дисертација [Интернет]. [Крагујевац]:[С. Минић Јанићијевић]; 2024. стр. 85 листова. Available at:https://phaidrakg.kg.ac.rs/o:1751
  13. Garza AP, Morton L, Pállinger É, Buzás EI, Schreiber S, Schott BH, et al. Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration. Brain Behav Immun Health. 2023; 28:100597.
  14. Faiz A, Mahbub RM, Boedijono FS, Tomassen MI, Kooistra W, Timens W, Nawijn M, Hansbro PM, Johansen MD, Pouwels SD, Heijink IH, Massip F, de Biase MS, Schwarz RF, Adcock IM, Chung KF, van der Does A, Hiemstra PS, Goulaouic H, Xing H, Abdulai R, de Rinaldis E, Cunoosamy D, Harel S, Lederer D, Nivens MC, Wark PA, Kerstjens HAM, Hylkema MN, Brandsma CA, van den Berge M. IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels. Am J Respir Crit Care Med. 2023; 208 (10):1075–87.
DOI: https://doi.org/10.2478/eabr-2026-0006 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 3 - 6
Submitted on: Dec 28, 2025
Accepted on: Feb 1, 2026
Published on: Jun 1, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Slavica Minic Janicijevic, Ivan P. Jovanovic, Zvezdana Stojanovic, Katarina Vesic, Milica M. Borovcanin, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.