Smoking May Impact IL-33/ST2 Signaling for Better Cognitive Functioning in Schizophrenia

Slavica Minic Janicijevic; Ivan P. Jovanovic; Zvezdana Stojanovic; Katarina Vesic; Milica M. Borovcanin

doi:10.2478/eabr-2026-0006

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Smoking May Impact IL-33/ST2 Signaling for Better Cognitive Functioning in Schizophrenia

EABR. Experimental and Applied Biomedical Research

Volume 27 (2026): Issue 1 (March 2026)

By: Slavica Minic Janicijevic, Ivan P. Jovanovic, Zvezdana Stojanovic, Katarina Vesic and Milica M. Borovcanin

Open Access

|Jun 2026

Abstract

We found a positive correlation between serum levels of interleukin-33 (IL-33) and the Montreal Cognitive Assessment (MoCA) score in patients with stable schizophrenia, as well as with specific sub-scores. Smoking appears to decrease serum levels of soluble IL-33 receptor, a suppressor of tumorigenicity (sST2), possibly resulting in IL-33’s indirect preservation of cognitive functioning.

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Articles in this issue

DOI: https://doi.org/10.2478/eabr-2026-0006 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454

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Language: English

Page range: 3 - 6

Submitted on: Dec 28, 2025

Accepted on: Feb 1, 2026

Published on: Jun 1, 2026

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Schizophrenia,

IL-33,

ST2,

Related subjects:

Clinical medicine, other

© 2026 Slavica Minic Janicijevic, Ivan P. Jovanovic, Zvezdana Stojanovic, Katarina Vesic, Milica M. Borovcanin, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 27 (2026): Issue 1 (March 2026)