References
- Cox G, Wright GD. Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. Int. J. Med. Microbiol. 2013; 303(6–7): 287–292.
- Handzlik A, Matys A, Kononowicz KK. Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus. Antibiotics. 2013; 2: 28–45.
- Nikaido H. Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. Semin. Cell Dev. Biol. 2001; 12(3): 215–223.
- Kohler T, Pechere JC, Plesiat P. Bacterial antibiotic efflux systems of medical importance. CMLS. 1999; 56(9–10): 771–778.
- Saier MH, Sliwinski MK, Paulsen IT, Pao SS, Skurray RA, Nikaido H. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 1998; 12(3): 256–274.
- Kvist M, Hanock V, Klemm P. Inactivation of efflux pumps abolishes bacterial biofilmformation. Appl. Environ. Microbiol. 2008; 74(23): 7376–7382.
- Bina XR, Lavine CL, Miller MA, Bina JE. The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice. FEMS Microb. Lett. 2008; 279(2): 226–233.
- Piddock LJ. Multidrug-resistance efflux pumps – not just for resistance. Nat. Rev. Microbiol. 2006; 4(8): 629–636.
- Baugh S, Ekanayaka AS, Piddock LJV, Webber MA. Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. J. Antimicrob. Chemother. 2012; 67(10): 2409–2417.
- Paulsen IT. Multidrug efflux pumps and resistance: regulation and evolution. Curr.Opin.Microbiol. 2003; 6(5): 446–451.
- Blair JM, Richmond GE, Piddock LJ. Multidrug efflux pumps in Gram–negative bacteria and their role in antibiotic resistance. Future Microbiol. 2014; 9(10): 1165–1177.
- Du D, Van Veen HW, Murakami S, Pos KM, Luisi BF. Structure, mechanism and cooperation of bacterial multidrug transporters. Curr. Opin. Struct. Biol. 2015; 33: 76–91.
- Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol. 1992; 8: 67–113.
- Davidson AL, Dassa E, Orelle C, Chen J. Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev. 2008; 72: 317–364.
- Greene NP, Kaplan E, Crow A, Koronakis V. Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective. Front. Microbiol. 2018; 9: 950.
- Du D, Wang Z, James NR. Structure of the AcrAB-TolC multidrug efflux pump. Nature. 2014; 509: 512–515.
- Colclough AL, Alav I, Whittle EE et al. RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance. Future Microbiol. 2020; 15: 143–157.
- Hagman KE, Lucas CE, Balthazar JT et al. The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system. Microbiology. 2017; 143(7): 2117–2125.
- Webber M, Piddock L. The importance of efflux pumps in bacterial antibiotic resistance. J. Antimicrobiol. Chemother. 2003; 51: 9–11.
- Srinivasan VB, Vaidyanathan V, Rajamohan G. AbuO, a TolC-like outer membrane protein of Acinetobacter baumannii, is involved in antimicrobial and oxidative stress resistance. Antimicrob. Agents Chemother. 2015; 59(2): 1236–1245.
- Pasqua M, Grossi M, Zennaro A et al. The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells. Microorganisms. 2019; 7: 285.
- Neuberger A, Du D, Luisi BF. Structure and mechanism of bacterial tripartite efflux pumps. Res. Microbiol. 2018; 169: 401–413.
- Resch A, Rosenstein R, Nerz C, Gotz F. Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions. Appl. Environ. Microbiol. 2005; 71: 2663–2676.
- Sahu PK, Iyer PS, Gaikwad MB, Talreja SC, Pardesi KR, Chopade BA. An MFS transporter-like ORF from MDR Acinetobacter baumannii AIIMS 7 is associated with adherence and biofilm formation on biotic/abiotic surface. Int. J. Microbiol. 2012; 2012: 490647.
- Pasqua M, Grossi M, Scinicariello S et al. The MFS efflux pump EmrKY contributes to the survival of Shigella within macrophages. Sci. Rep. 2019; 9: 2906–2911.
- Sharma A, Sharma R, Bhattacharyya T, Bhando T, Pathania R. Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter-AbaF. J. Antimicrob. Chemother. 2017; 72: 68–74.
- Perez VM, Corral J, Vallejo JA et al. Mutations in the β-Subunit of the RNA Polymerase Impair the Surface-Associated Motility and Virulence of Acinetobacter baumannii. Infect. Immun. 2017; 85(8): e00327–17.
- Holdsworth SR, Law CJ. The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds. J. Antimicrob. Chemother. 2013; 68: 831–839.
- Kazimierczak KA, Rincon MT, Patterson AJ et al. Antimicrob. Agents Chemother. 2008; 52: 4001–4009.
- Paulsen T, Skurray RA, Tam R et al. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol. Microbiol. 1996; 19(6): 1167–1175.
- Roca I, Marti S, Espinal P, Martinez P, Gibert I, Vila J. CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 2009; 53: 4013–4014.
- Srinivasan VB, Rajamohan G, Gebreys WA. Role of AbeS, a novel efflux pump of SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Antimicrob. Agents Chemother. 2009; 53: 5312–5316.
- Kuroda T, Tsuchiya T. Multidrug efflux transporters in the MATE family. Biochim. Biophys. Acta. 2009; 1794(5): 763–768.
- He GX, Kuroda T, Mima T, Morita Y, Mizushima T, Tsuchiya T. An H+-coupled multidrug efflux pump, PmpM, a member of MATE family of transporters, from Pseudomonas aeruginosa. J. Bacteriol. 2004; 186: 262–265.
- Subramaniam G, Girish M. Antibiotic Resistance - A Cause for Reemergence of Infections. Indian J Pediatr. 2020; 87(11): 937–944.
- Rather IA, Kim BC, Bajpai VK, Park YH. Self-medication and antibiotic resistance: Crisis, current challenges, and prevention. Saudi J Biol Sci. 2017; 24(4): 808–812.
- Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A. Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol. Microbiol. 2005; 55: 1113–1126.
- Yamasaki S, Nikaido E, Nakashima R et al. The crystal structure of multidrug-resistance regulator RamR with multiple drugs. Nat Commun. 2013; 4: 2078.
- Okusu H, Ma D, Nikaido H. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 1996; 178: 306–308.
- Ma D, Alberti M, Lynch C, Nikaido H, Hearst JE. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol. Microbiol. 1996; 19: 101–112.
- Ricci V, Busby SJW, Piddock LJV. Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor. Antimicrob. Agents Chemother. 2012; 56: 6037–6040.
- Abouzeed YM, Baucheron S, Cloeckaert A. ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica servoar Typhimurium. Antimirob. Agents Chemother. 2008; 52: 2428–2434.
- Ricci V, Blair JM, Piddock LJ. RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease. J. Antimicrob. Chemothher. 2014; 69: 643–650.
- Tierney AR, Rather PN. Roles of two-component regulatory systems in antibiotic resistance. Future Microbiol. 2019; 14(6): 533–552.
- Mitrophanov AY, Groisman EA. Signal integration in bacterial two-component regulatory systems. Genes Dev. 2008; 22: 2601–2611.
- Korteke KK, Lupas AN, Warren PV Rosenberg M, Brown JR. Evolution of two-component signal transduction. Mol.Biol.Evol. 2000; 17(12): 1956–1970.
- Morita Y, Cao L, Gould VC, Avison MB, Poole K. NalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. J. Bacteriol. 2006; 188: 8649–8654.
- Warner DM, Shafer WM, Jerse AE. Clinicaly relevant mutations that cause dewepewsion of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol. Mirobiol. 2008; 70(8): 462–478.
- Baucheron S, Coste F, Canepa S et al. Binding of the RamR repressor to wild-type and mutated promoters of the RamA gene involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 2021; 56: 942–948.
- Stavri M, Piddock LJ, Gibbons S. Bacterial efflux pump inhibitors from natural sources. J Antimicrob Chemother. 2007; 59(6): 1247–1260.
- Sabatini S, Gosetto F, Serritella S et al. Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: A promising new class of Staphylococcus aureus NorA efflux pump inhibitors. J. Med. Chem. 2012; 55: 3568–3572.
- Mahamoud A, Chevalier J, Alibert-Franco S, Kern WV, Pages JM. Antibiotic efflux pumps in Gram-negative bacteria: The inhibitor response strategy. J. Antimicrob. Chemother. 2007; 59: 1223–1229.
- Poole K, Lomovskaya O. Can efflux inhibitors really counter resistance? Drug Discov. Today. 2006; 3: 145–152.
- Michalet S, Cartier G, David B et al. N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. Bioorg. Med. Chem. Lett. 2007; 17: 1755–1758.
- Baugh S, Philips CR, Ekanayaka AS, Piddock LJV, Webber MA. Inhibition of multidrug efflux s a strategy to prevent biofilm formation. J. Antimicrob. Chemother. 2014; 69(3): 673–681.
- Lomovskaya O, Bostian KA. Pracical applications and feasibility of efflux pump inhibitors in the clinic – a vision for applied use. Biochem. Pharmacol. 2006; 71(7): 910–918.
- Li H, Wang X, Zhang Y et al. The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates. Future Microbiol. 2015; 10: 337–346.
- Nowak J, Seifert H, Higgins PG. Prevalence of eight resistancenodulation-division efflux pump genes in epidemiologically characterized Acinetobacter baumannii of worldwide origin. J Med Microbiol. 2015; 64: 630–635.
- Hagman KE, Lucas CE, Balthazar JT et al. The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system. Microbiology. 2017; 143(7): 2117–2125.
- Eaves DJ, Ricci V, Piddock LJ. Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance. Antimicrob. Agents Chemother. 2004; 48(4): 1145–1150.
- Eicher T, Cha HJ, Seeger MA et al. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc. Natl. Acad. Sci. 2021;109(15):5687–5692.
- Su CC, Long F, Zimmermann MT, Rajashankar KT, Jernigan RL, Yu EW. Crystal structure of the CusBA heavy-metal efflux complex of Escerichia coli. Nature. 2011;47(7335):558–562.
- Morita Y, Sobel ML, Poole K. Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product. J. Bacteriol. 2006;188(5):1847–1855.